Abstract
It has long been known that the presence of glucose (or of another easily degradable carbon source) inhibits the synthesis of certain bacterial enzymes such as β-galactosidase or tryptophanase from E. coli, or inositol dehydrogenase and histidase from Bacillus subtilis. This phenomenon was called glucose effect. In 1961, Magasanik gave it the more general name of catabolic repression. Many catabolic enzymes being inducible, the rate of their synthesis must then depend on the intracellular concentrations of the inducer and of the catabolite exerting its repressive effect.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Selected References
Catabolic Repression
B. Magasanik, Cold Spring Harbor Symp. Quant. Biol., 26, 249–256 (1961).
Effects of Cyclic AMP on the Glucose Effect
R. S. Makman and E. W. Sutherland, J. Biol. Chem., 240, 1309–1313 (1965).
R. Perlman and I. Pastan, Biochem. Biophys. Res. Comm., 30, 656–664 (1968) and 37, 151–157 (1969).
A. Ullman and J. Monod, FEBS Letters, 2, 57–60 (1968).
The Promoter
F. Jacob, A. Ullman et J. Monod, Comptes rendus, 258, 3125–3128 (1964).
The CAP Protein
D. A. Chambers and G. Zubay, Proc. Natl. Acad. Sci. U. S., 63, 118–122 (1969).
G. Zubay, D. Schwartz and J. Beckwith, Proc. Natl. Acad. Sci. U. SA., 66, 104–110 (1970).
Mode of Action of Cyclic AMP
A. Ullmann and A. Danchin, Adv. Cyclic Nucleotide Research, 15, 1–53 (1983).
N. D. Meadow, D. K. Fox and S. Roseman, Ann. Rev. Biochem., 59, 497–542 (1990).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2010 Springer Netherlands
About this chapter
Cite this chapter
Cohen, G.N. (2010). Positive Regulation. In: Microbial Biochemistry. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9437-7_18
Download citation
DOI: https://doi.org/10.1007/978-90-481-9437-7_18
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-9436-0
Online ISBN: 978-90-481-9437-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)