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3D-Fiber Deposition for Tissue Engineering and Organ Printing Applications

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Cell and Organ Printing

Abstract

Scaffold manufacturing technologies are moving towards systems that combine a precise control over scaffold 3-dimensional (3D) architecture with incorporation of cells in the fabrication process. A rapid prototyping technology, termed 3D-fiber deposition, generates 3D scaffolds that can satisfy these requirements, while maintaining a completely open porosity that can reduce nutrient diffusion limitations. This extrusion-based technique is effective in fabrication of porous thermoplastic scaffolds that function as instructive templates for seeded cells and can also be used to build viable tissue equivalents by layered deposition of cell-laden hydrogels. Therefore, this technology could accelerate and improve the assembly and functionality of tissue-engineered constructs.

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Acknowledgements

We acknowledge the financial support of the Mosaic scheme 2004 of the Netherlands Organization for Scientific Research (NWO; grant number: 017.001.181), the Dutch Program for Tissue Engineering (project number: UGT.6743), VENI fellowship (project number: UGT.07825) from the Dutch Technology Foundation STW, Applied Science Division of NWO and the Technology Program of the Ministry of Economic Affairs, the Anna Foundation and the Smart Mix Program of the Netherlands Ministry of Economic Affairs and the Netherlands Ministry of Education, Culture and Science.

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Authors and Affiliations

  1. Department of Orthopaedics, University Medical Center Utrecht, 3508, GA, Utrecht, The Netherlands

    N.E. Fedorovich, J. Malda, J. Alblas & W.J.A. Dhert

  2. Institute for BioMedical Technology (BMTI), University of Twente, 7500, AE, Enschede, The Netherlands

    L. Moroni & C.A. van Blitterswijk

  3. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, 4001, Australia

    J. Malda

  4. Faculty of Veterinary Medicine, Utrecht University, 3508, TD, Utrecht, The Netherlands

    W.J.A. Dhert

Authors
  1. N.E. Fedorovich
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  2. L. Moroni
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  3. J. Malda
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  4. J. Alblas
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  5. C.A. van Blitterswijk
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  6. W.J.A. Dhert
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Corresponding authors

Correspondence to N.E. Fedorovich or L. Moroni .

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Editors and Affiliations

  1. Div. Chemistry, Code 6113, Naval Research Laboratory (NRL), Overlook Ave. SW., 4555, Washington, 20375, District of Columbia, USA

    Bradley R. Ringeisen

  2. Chemical Dynamics and Diagnostics Branch, Code 6113, Naval Research Laboratory (NRL), Overlook Ave. SW., 4555, Washington, 20375, District of Columbia, USA

    Barry J. Spargo

  3. Div. Chemistry, Code 6113, Naval Research Laboratory (NRL), Overlook Ave. SW., 4555, Washington, 20375, District of Columbia, USA

    Peter K. Wu

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Fedorovich, N., Moroni, L., Malda, J., Alblas, J., van Blitterswijk, C., Dhert, W. (2010). 3D-Fiber Deposition for Tissue Engineering and Organ Printing Applications. In: Ringeisen, B., Spargo, B., Wu, P. (eds) Cell and Organ Printing. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9145-1_13

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