Skip to main content
SpringerLink
Log in

Extracellular Matrix and Tissue Regeneration

  • Chapter
  • First Online:
Regenerative Medicine

Abstract

Extracellular matrix (ECM) is an important component of stem cell niche areas, which provide residence, regulate stem cell pool size and control stem cell mobilization. ECM is a complex interlinked composite of collagenous molecules, non-collagenous molecules and water-rich mucopolysaccharide ground substance. Cells are integrated to their matrix via integrin and non-integrin receptors, which are utilized in the control of adhesion, migration, division, growth, anoikis, transdifferentiation and other cellular behaviour. ECM provides architecture and strength, but also growth factor deposits, which proteinases as signalling scissors can release in a site- and ­process-specific manner. Several processes, like wounds, cartilage, fractures, myocardial infarctions and tumor growth are used to exemplify regenerative processes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Ågren, M. S., Eaglstein, W. H., Ferguson, M. W., Harding, K. G., Moore, K., Saarialho-Kere, U. K., Schultz, G. S. (2000) Causes and effects of the chronic inflammation in venous leg ulcers. Acta Dermato-Venereologica. Supplementum 210:3–17.

    PubMed  Google Scholar 

  • Ågren, M. S., Werthén, M. (2007) The extracellular matrix in wound healing: a closer look at therapeutics for chronic wounds. International Journal of Lower Extremity Wounds 6:82–97.

    PubMed  Google Scholar 

  • Alford, J. W., Cole, B. J. (2005) Cartilage restoration, part 1: basic science, historical perspective, patient evaluation, and treatment options. American Journal of Sports Medicine 33:295–306.

    PubMed  Google Scholar 

  • Allemann, F., Mizuno, S., Eid, K., Yates, K. E., Zaleske, D. and Glowacki, J. (2001) Effects of hyaluronan on engineered articular cartilage extracellular matrix gene expression in 3-­dimensional collagen scaffolds. Journal of Biomedical Materials Research 55:13–19.

    CAS  PubMed  Google Scholar 

  • Alsalameh, S., Amin, R., Gemba, T., Lotz, M. (2004) Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage. Arthritis and Rheumatism 50:1522–1532.

    PubMed  Google Scholar 

  • Amalinei, C., Caruntu, I-D., Balan, R.A. (2007) Biology of metalloproteinases. Romanian Journal of Morphology and Embryology 48:323–333.

    CAS  PubMed  Google Scholar 

  • Angata, T., Brinkman-van der Linden, E. C. M. (2002) I-type lectins. Biochimica et Biophysica Acta 1572:294–316.

    CAS  PubMed  Google Scholar 

  • Arikawa, T., Matsukawa, A., Watanabe, K., Sakata, K.M., Seki, M., Nagayama, M., Takeshita, K., Ito, K., Niki, T., Oomizu, S., Shinonaga, R., Saita, N., Hirashima, M. (2009) Galectin-9 accelerates transforming growth factor beta3-induced differentiation of human mesenchymal stem cells to chondrocytes. Bone 44:849–857.

    CAS  PubMed  Google Scholar 

  • Askari, A., Brennan, M. L., Zhou, X., Drinko, J., Morehead, A., Thomas, J. T., Topol, E. J., Hazen, S. L., Penn, M. S. (2003) Myeloperoxidase and plasminogen activator inhibitor-1 play a central role in ventricular remodeling after myocardial infarction. The Journal of Experimental Medicine 197:615–624.

    CAS  PubMed  Google Scholar 

  • Aszódi, A., Legate, K. R., Nakchbandi, I., Fässler, R. (2006) What mouse mutants teach us about extracellular matrix function. Annual Review of Cell and Developmental Biology 22:591–621.

    PubMed  Google Scholar 

  • Aumailley, M., Bruckner-Tuderman, L., Carter, W. G. et al. (2005) A simplified laminin nomenclature. Mini review. Matrix Biology 24:326–332.

    CAS  Google Scholar 

  • Badylak, S. F. (2002) The extracellular matrix as a scaffold for tissue reconstruction. Seminars in Cell & Developmental Biology 13:377–383.

    CAS  Google Scholar 

  • Bani, D., Nistri, S., Formigli, L., Meacci, E., Francini, F., Zecchi-Orlandini, S. (2009) Prominent role of relaxin in improving postinfarction heart remodeling. Clues from in vivo and in vitro studies with genetically engineered relaxin-producing myoblasts. Annals of the New York Academy of Sciences 1160:269–277.

    CAS  PubMed  Google Scholar 

  • Battiwalla, M., Hematti, P. (2009) Mesenchymal stem cells in hematopoietic stem cell transplantation. Cytotherapy 11:503–515.

    PubMed  Google Scholar 

  • Beauvais, D. M., Ell, B. J., McWhorter, A. R., Rapraeger, A. C. (2009) Syndecan-1 regulates αVβ3 and αvβ5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor. Journal of Experimental Medicine 206:691–705.

    CAS  PubMed  Google Scholar 

  • Bernfield, M., Kokenyesi, R., Kato, M., Hinkes, M. T., Spring, J., Gallo, R. L., Lose, E. J. (1992) Biology of the syndecans: a family of transmembrane heparan sulfate proteoglycans. Annual Review of Cell Biology 8:365–393.

    CAS  PubMed  Google Scholar 

  • Borza, D. B., Bondar, O., Ninomiya, Y., Sado, Y., Naito, I., Todd, P., Hudson, B. G. (2001) The NC1 domain of collagen IV encodes a novel network composed of the alpha 1, alpha 2, alpha 5, and alpha 6 chains in smooth muscle basement membranes. Journal of Biological Chemistry 276:28532–28540.

    CAS  PubMed  Google Scholar 

  • Boutaud, A., Borza, D. B., Bondar, O., Gunwar, S., Netzer, K. O., Singh, N., Ninomiya, Y., Sado, Y., Noelken, M. E., Hudson, B. G. (2000) Type IV collagen of the glomerular basement membrane. Evidence that the chain specificity of network assembly is encoded by the noncollagenous NC1 domains. Journal of Biological Chemistry 275:30716–30724.

    CAS  PubMed  Google Scholar 

  • Brody, S., Pandit, A. (2007) Approaches to heart valve tissue engineering scaffold design. Journal of biomedical materials research. Part B, Applied biomaterials 83:16–43.

    PubMed  Google Scholar 

  • Brooks, P. C., Clark, R. A. F., Cheresh, D. A. (1994) Requirement of vascular integrin αVβ3 for angiogenesis. Science 264:569–571.

    CAS  PubMed  Google Scholar 

  • Bullard, K. M., Longaker, M. T. & Lorenz, H. P. (2003) Fetal wound healing: current biology. World Journal of Surgery 27:54–61.

    PubMed  Google Scholar 

  • Canty, E. G., Kadler, K. E. (2005) Procollagen trafficking, processing and fibrillogenesis. Journal of Cell Science 118:1341–1353.

    CAS  PubMed  Google Scholar 

  • Capito, R. M., Spector, M. (2003) Scaffold-based articular cartilage repair. IEEE engineering in medicine and biology magazine: the quarterly magazine of the Engineering in Medicine & Biology Society 22:42–50.

    Google Scholar 

  • Clark, R. A. F. (1995) Wound repair: Overview and general considerations. The Molecular and Cellular Biology of Wound Repair (2nd edition), 513–560, Plenum, New York.

    Google Scholar 

  • Cosgrove, D., Meehan, D. T., Grunkemeyer, J. A., Kornak, J. M., Sayers, R., Hunter, W. J., Samuelson, G. C. (1996) Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome. Genes and Development 10:2981–2992.

    CAS  PubMed  Google Scholar 

  • Coussens, L. M., Fingleton, B., Matrisian, L. M. (2002) Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 295:2387–2392.

    CAS  PubMed  Google Scholar 

  • Creemers, E. E., Cleutjens, J. P., Smits, J. F., Daemen, M. J., (2001) Matrix metalloproteinase inhibition after myocardial infarction: a new approach to prevent heart failure? Circulation Research 89:201–210.

    Google Scholar 

  • Crisostomo, P. R., Markel, T. A., Wang, Y. Meldrum D. R (2008) Surgically relevant aspects of stem cell paracrine effects. Surgery 143:577–581.

    PubMed  Google Scholar 

  • Cui, F-Z., Li, Y., Ge, J. (2007) Self-assembly of mineralized collagen composites. Materials Science & Engineering R 57:1–27.

    Google Scholar 

  • Davis, G. E., Senger, D. R. (2005) Endothelial extracellular matrix. Biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Circulation Research 97:1093–1107.

    CAS  PubMed  Google Scholar 

  • Deten, A., Holzl, A., Leicht, M., Barth, W., Zimmer, H. G. (2001) Changes in extracellular matrix and in transforming growth factor beta isoforms after coronary artery ligation in rats. Journal of Molecular and Cellular Cardiology 33:1191–1207.

    CAS  PubMed  Google Scholar 

  • Deten, A., Volz, H. C., Briest, W., Zimmer, H. G. (2002) Cardiac cytokine expression is upregulated in the acute phase after myocardial infarction. Experimental studies in rats. Cardiovascular Research 55:329–340.

    CAS  PubMed  Google Scholar 

  • Di Guglielmo, G. M., Le Roy, C., Goodfellow, A. F., Wrana, J. L. (2003) Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nature Cell Biology 5:410–421.

    PubMed  Google Scholar 

  • Docheva, D., Popov, C., Mutschler, W., Schieker, M. (2007) Human mesenchymal stem cells in contact with their environment: surface characteristics and the integrin system. Journal of Cellular and Molecular Medicine 11:21–38.

    CAS  PubMed  Google Scholar 

  • Doe, C. Q., Bowerman, B. (2001) Asymmetric cell division: fly neuroblast meets worm zygote. Current Opinion in Cell Biology 13:68–75.

    CAS  PubMed  Google Scholar 

  • East, L., Isacke, C. M. (2002) The mannose receptor family. Biochimica et biophysica acta 1572:364–386.

    CAS  PubMed  Google Scholar 

  • Eckes, B., Kessler, D., Aumailley, M., Krieg, T. (1999) Interactions of fibroblasts with the extracellular matrix:implications for the understanding of fibrosis. Springer Seminars in Immunopathology 21:415–429.

    CAS  PubMed  Google Scholar 

  • Egeblad, M., Werb, Z. (2002) New functions for the matrix metalloproteinases in cancer progression. Nature reviews. Cancer 2:161–174.

    CAS  PubMed  Google Scholar 

  • Egles, C., Claudepierre, T., Manglapus, M. K., Champliaud, M. F., Brunken, W. J., Hunter, D. D. Laminins containing the beta2 chain modulate the precise organization of CNS synapses. Molecular and Cellular Neuroscience 2007;34:388–398.

    CAS  PubMed  Google Scholar 

  • Ekblom, P., Lonai, P., Talts, J. F. (2003) Expression and biological role of laminin-1. Matrix Biology : Journal of the International Society for Matrix Biology 22:35–47.

    Google Scholar 

  • Eklund, L., Piuhola, J., Komulainen, J., Sormunen, R., Ongvarrasopone, C., Fássler, R., Muona, A., Ilves, M., Ruskoaho, H., Takala, T. E., Pihlajaniemi, T. (2001) Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice. Proceedings of the National Academy of Sciences of the United States of America 98:1194–1199.

    CAS  PubMed  Google Scholar 

  • Ellis, S. J., Tanantzapf, G. (2009) Integrin-mediated adhesion and stem-cell-niche interactions. Cell and Tissue Research [Epub ahead of print].

    Google Scholar 

  • Engler, A. J., Sen. S., Sweeney, H. L., Discher, D. E. (2006) Matrix elasticity directs stem cell lineage specification. Cell 126:677–689.

    CAS  PubMed  Google Scholar 

  • Fanjul-Fernández, M., Folgueras, A. R., Cabrera, S., López-Otin, C. (2009) Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models. Biochimica et Biophysica Acta, E-pub ahead of print.

    Google Scholar 

  • Fawcett, J. W., Asher, R. A. (1999) The glial scar and central nervous system repair. Brain Research Bulletin 49:377–391.

    CAS  PubMed  Google Scholar 

  • Fortier, L. A., Mohammed, H. O., Lust, G., Nixon, A. J. (2002) Insulin-like growth factor-I enhances cell-based repair of articular cartilage. Journal of Bone and Joint Surgery, British volume 84-B:276–288.

    Google Scholar 

  • Fox, J.M., Ghamberlain, G., Ashton, B.A., Middleton, J. (2007) Recent advances into the understanding of mesenchymal stem cell trafficking. British Journal of Haematology 137:491–502.

    CAS  PubMed  Google Scholar 

  • Fox, J.W., Mayer, U., Nischt, R., Aumailley, M., Reinhardt, D., Wiedemann, H., Mann, K., Timpl, R., Krieg, T., Engel, J., Chu, M-L. (1991) Recombinant nidogen consists of three globular domains and mediates binding of laminin to collagen type IV. EMBO Journal 10:3137–3146.

    CAS  PubMed  Google Scholar 

  • Fukai, N., Eklund, L., Marneros, A. G., Oh, S. P., Keene, D. R., Tamarkin, L., Niemelä, M., Ilves, M., Li, E., Pihlajaniemi, T., Olsen, B. R. (2002) Lack of collagen XVIII/endostatin results in eye abnormalities. EMBO Journal 21:1535–1544.

    CAS  PubMed  Google Scholar 

  • Getgood, A., Brooks, R., Fortier, L., Rushton, N. (2009) Articular cartilage tissue engineering: today’s research, tomorrow’s practice? Journal of Bone and Joint Surgery, British volume 91:565–576.

    CAS  Google Scholar 

  • Glowacki, J., Mizuno, S. (2007) Collagen scaffolds for tissue engineering. Biopolymers 89:338–344.

    Google Scholar 

  • Gohring, W., Sasaki, T., Heldin, C.H., Timpl, R. (1998) Mapping of the binding of platelet-derived growth factor to distinct domains of the basement membrane proteins BM-40 and perlecan and distinction from the BM-40 collagen-binding epitope. European Journal of Biochemistry 255:60–66.

    CAS  PubMed  Google Scholar 

  • Gray, H., Bannister, L. H., Berry, M. M., Williams, P. L. (1995) Gray’s Anatomy: The Anatomical Basis of Medicine and Surgery. Churchill Livingstone: Edinburgh.

    Google Scholar 

  • Gronthos, S., Simmons, P. J, Graves, S. E., Robey, P. G. (2001) Integrin-mediated interactions between human bone marrow stromal precursor cells and the extracellular matrix. Bone 28:174–181.

    CAS  PubMed  Google Scholar 

  • Guo, T., Zhao, J., Chang, J., Ding, Z., Hong, H., Chen, J., Zhang, J. (2006) Porous chitosan-gelatin scaffold containing plasmid DNA encoding transforming growth factor-beta1 for chondrocytes proliferation. Biomaterials 27:1095–1103.

    CAS  PubMed  Google Scholar 

  • Hayes, A.J., Tudor, D., Nowell, M.A., Caterson, B., Hughes, C.E. (2008) Chondroitin sulphate sulfation motifs as putative biomarkers for isolation of articular cartilage progenitor cells. Journal of Histochemistry and Cytochemistry 56:125–138.

    CAS  PubMed  Google Scholar 

  • Heino, J. (2007) The collagen family members as cell adhesion proteins. BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology 29:1001–1010.

    CAS  PubMed  Google Scholar 

  • Heino, J., Käpylä, J. (2009) Cellular receptors of extracellular matrix molecules. Current Pharmaceutical Design 15:1309–1317.

    Google Scholar 

  • Heinola, T., Kouri, V-P., Clarijs, P., Ciferska, H., Sukura, A., Salo, J., Konttinen, Y. T. (2010) High mobility group box-1 (HMGB-1) in osteoarthritic cartilage. Clinical and Experimental Rheumatology 28:511–8.

    Google Scholar 

  • Herrick, S. E., Ireland, G. W., Simon, D., McCollum, C. N., Ferguson, M. W. (1996) Venous ulcer fibroblasts compared with normal fibroblasts show differences in collagen but not fibronectin production under both normal and hypoxic conditions. Journal of Investigative Dermatology 106:187–193.

    CAS  PubMed  Google Scholar 

  • Herrick, S. E., Sloan, P., McGurk, M., Freak, L., McCollum, C. N., Ferguson, M. W. (1992) Sequential changes in histologic pattern and extracellular matrix deposition during the healing or chronic venous ulcers. American Journal of Pathology 141:1085–1095.

    CAS  PubMed  Google Scholar 

  • Hodde, J. P., Johnson, C. E. (2007) Extracellular matrix as a strategy for treating chronic wounds. American Journal of Clinical Dermatology 8:61–66.

    PubMed  Google Scholar 

  • Hoemann, C. D., Sun, J., McKee, M. D., Chevrier, A., Rossomacha, E., Rivard, G. E., Hurtig, M., Buschmann, M. D. (2007) Chitosan-glycerol phosphate/blood implants elicit hyaline cartilage repair integrated with porous subchondral bone in microdrilled rabbit defects. Osteoarthritis and Cartilage 15:78–89.

    CAS  PubMed  Google Scholar 

  • Hudson, B. G. (2004) The molecular basis of Goodpasture and Alport syndromes: beacons for the discovery of the collagen IV family. Journal of the American Society of Nephrology 15:2514–2527.

    PubMed  Google Scholar 

  • Hudson, B. G., Tryggvason, K., Sundaramoorthy, M., Neilson, E. G. (2003) Alport’s syndrome, Goodpasture’s syndrome, and type IV collagen. New England Journal of Medicine 348:2543–2556.

    CAS  PubMed  Google Scholar 

  • Humphries, J. D., Byron, A., Humphries, M. J. (2006) Integrin ligands at a glance. Journal of Cell Science 119:3901–3903.

    CAS  PubMed  Google Scholar 

  • Hutmacher, D. W. (2000) Scaffolds in tissue engineering bone and cartilage. Biomaterials 21:2529–2543.

    CAS  PubMed  Google Scholar 

  • Hutmacher, D. W., Kirsch, A., Ackermann, K. L., Huerzeler, M. B. (1998) Matrix and carrier materials for bone growth factors – state of the art and future perspectives. In Biological Matrices and Tissue Reconstruction, Stark, G. B., Horch, R., Tancos, E. (eds). Springer Verlag: Heidelberg, 197–206.

    Google Scholar 

  • Hwang, M. W., Matsumori, A., Furukawa, Y., Ono, K., Okada, M., Iwasaki, A., Hara, M., Miyamoto, T., Touma, M., Sasayama, S. (2001) Neutralization of interleukin-1beta in the acute phase of myocardial infarction promotes the progression of left ventricular remodeling. Journal of the American College of Cardiology 38:1546–1553.

    CAS  PubMed  Google Scholar 

  • Imanaka-Yoshida, K., Hiroe, M., Nishikawa, T., Ishiyama, S., Shimojo, T., Ohta, Y., Sakakura, T., Yoshida, T. (2001) Tenascin-C modulates adhesion of cardiomyocytes to extracellular matrix during tissue remodeling after myocardial infarction. Laboratory Investigation; a Journal of Technical Methods and Pathology 81:1015–1024.

    CAS  PubMed  Google Scholar 

  • Ip, J. E., Wu, Y., Huang, J., Zhang, L., Pratt, R. E., Dzau, V. J. (2007) Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment. Molecular biology of the cell 18:2873–2882.

    CAS  PubMed  Google Scholar 

  • Irwin, C. R., Myrillas, T., Smyth, M., Doogan, J., Rice, C. and Schor, S. L. Regulation of fibroblast-induced collagen gel contraction by interleukin-1b. (1998) Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 27:255–259.

    CAS  Google Scholar 

  • Iwakura, A., Shastry, S., Luedemann, C., Hamada, H., Kawamoto, A., Kishore, R., Zhu, Y., Qin, G., Silver, M., Thorne, T., Eaton, L., Masuda, H., Asahara, T., Losordo, D. W. (2006) Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9. Circulation 113:1605–1614.

    CAS  PubMed  Google Scholar 

  • Jäälinoja, J. (2007) The structure and function of normal and mutated collagen IX. Thesis work. Oulu University press.

    CAS  PubMed  Google Scholar 

  • Jones, J. C., Dehart, G. W., Gonzales, M., Goldfinger, L. E. (2000). Laminins: an overview. Microscopy Research and Technique 51:211–213.

    CAS  PubMed  Google Scholar 

  • Juncosa-Melvin, N., Shearn, J. T., Boivin, G. P., Gooch, C., Galloway, M. T., West, J. R., Nirmalanandhan, V. S., Bradica, G., Butler, D. L. (2006) Effects of mechanical stimulation on the biomechanics and histology of stem cell-collagen sponge constructs for rabbit patellar tendon repair. Tissue Engineering 12:2291–2300.

    CAS  PubMed  Google Scholar 

  • Kalluri, R. (2003) Basement membranes: structure, assembly and role in tumour angiogenesis. Nature Reviews Cancer 3:422–433.

    CAS  PubMed  Google Scholar 

  • Karadag, A., Fisher, L. W. (2006) Bone sialoprotein enhances migration of bone marrow stromal cells through matrices by bridging MMP-2 to alpha(v)beta3-integrin. Journal of Bone and Mineral Research 21:1627–1636.

    CAS  PubMed  Google Scholar 

  • Kato, Y., Nishikawa, T., Kawakishi, S. (1995) Antioxidative activity of tetrahydrocurcuminoids. Photochemistry and Photobiology 61:367–372.

    CAS  PubMed  Google Scholar 

  • Katsuragi, N., Morishita, R., Nakamura, N., Ochiai, T., Taniyama, Y., Hasegawa, Y., Kawashima, K., Kaneda, Y., Ogihara, T., Sugimura, K. (2004) Periostin as a novel factor responsible for ventricular­ dilation. Circulation 110:1806–13.

    CAS  PubMed  Google Scholar 

  • Katz, S (2007) Role of basement membrane and extracellular matrix proteins in the adhesion and spreading of immortalized human corneal epithelial cells. Thesis work. Helsinki University Printing House.

    CAS  PubMed  Google Scholar 

  • Kefalides, N. A. (1966) A collagen of unusual composition and a glycoprotein isolated from canine glomerular basement membrane. Biochemical and Biophysical Research Communications 22:26–32.

    CAS  PubMed  Google Scholar 

  • Khang, D., Park, G. E., Webster, T. J. (2008) Enhanced chondrocyte densities on carbon nanotube composites: the combined role of nanosurface roughness and electrical stimulation. Journal of Biomedical Materials Research, Part A 86-A:253–260.

    Google Scholar 

  • Khoshnoodi, J., Pedchenko, V., Hudson, B. G. (2008) Mammalian collagen IV. Microscopy Research and Techique 71:357–370.

    CAS  Google Scholar 

  • Kikkawa, Y., Moulson, C. L., Virtanen, I., Miner, J. H. (2002) Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo. The Journal of Biological Chemistry 277:44864–44869.

    CAS  PubMed  Google Scholar 

  • Kleinman, H. K., Klebe, R. J., Martin, G. R. (1981) Role of collagenous matrices in the adhesion and growth of cells. Journal of Cell Biology 88:473–485.

    CAS  PubMed  Google Scholar 

  • Knudson, W., Casey, B., Nishida, Y., Eger, W., Kuettner, K. E., Knudson, C. B. (2000) Hyaluronan oligosacchrarides perturb cartilage matrix homeostasis and induce chondrocytic chondrolysis. Arthritis and Rheumatism 43:1165–1174.

    CAS  PubMed  Google Scholar 

  • Ko, G. J., Kang, Y. S., Han, S. Y., Lee, M. H., Song, H. K., Han, K. H., Kim, H. K., Han, J. Y., Cha, D. R. (2008) Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. Nephrology Dialysis Transplantation 23:2750–2760.

    CAS  Google Scholar 

  • Koenig, A., Mueller, C., Hasel, C., Adler, G., Menke, A. (2006) Collagen type I induces disruption of E-cadherin-mediated cell-cell contacts and promotes proliferation of pancreatic carcinoma cells. Cancer Research 66(9):4662–4671.

    CAS  PubMed  Google Scholar 

  • Kohfeldt, E., Sasaki, T., Gohring, W., Timpl, R. (1998) Nidogen-2: a new basement membrane protein with diverse binding properties. Journal of Moleclular Biology 282:99–109.

    CAS  Google Scholar 

  • Kuhn, B., del Monte F., Hajjar, R. J., Chang, Y. S., Lebeche, D., Arab, S., Keating, M. T. (2007) Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nature Medicine 13:962–9.

    PubMed  Google Scholar 

  • Kuo, C. K., Tuan, R. S. (2008) Mechanoactive tenogenic differentiation of human mesenchymal stem cells. Tissue Engeneering Part A 14:1615–1627.

    CAS  Google Scholar 

  • Kvist, A. P., Latvanlehto, A., Sund, M., Eklund, L., Väisänen, T., Hägg, P., Sormunen, R., Komulainen, J., Fässler, R., Pihlajaniemi, T. (2001) Lack of cytosolic and transmembrane domains of type XIII collagen results in progressive myopathy. American Journal of Pathology 159:1581–1592.

    CAS  Google Scholar 

  • Laflamme, M. A. (2007) Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nature Biotechnology 25:1015–1024.

    CAS  PubMed  Google Scholar 

  • Laflamme, M. A., Murry, C. E. (2005) Regenerating the heart. Nature Biotechnology 23:845–856.

    CAS  PubMed  Google Scholar 

  • Laine, M., Virtanen, I., Porola, P., Rotar, Z., Rozman, B., Poduval, P., Konttinen, Y. T. (2008) Acinar epithelial cell laminin-receptors in labial salivary glands in Sjögren’s syndrome. Clinical and Experimental Rheumatology 26:807–813.

    CAS  PubMed  Google Scholar 

  • Laine, M., Virtanen, I., Salo, T., Konttinen, Y. T. (2004) Segment-specific but pathologic laminin isoform profiles in human labial salivary glands of patients with Sjögren´s syndrome. Arthritis and Rheumatism 50:3968–3973.

    CAS  PubMed  Google Scholar 

  • Laurens, N., Engelse, M. A., Jungerius, C., Löwik, C. W., van Hinsbergh, V. W. M., Koolwijk, P. (2009) Single and combined effects of avb3- and a5b1-integrins on capillary tube formation in a human fibrinous matrix. Angiogenesis 12:275–285.

    CAS  PubMed  Google Scholar 

  • Leitinger, B., Hohenester, E. (2007) Mammalian collagen receptors. Matrix Biology: Journal of the International Society for Matrix Biology 26:146–155

    CAS  PubMed  Google Scholar 

  • Li, G., Zhang, X. A., Wang, H., Wang, X., Meng, C. L., Chan, C. Y., Yew, D. T., Tsang, K. S., Li, K., Tsai, S. N., Ngai, S. M., Han, Z. C., Lin, M. C., He, M. L., Kung, H. F. (2009) Comparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord, and placenta: implication in the migration. Proteomics 9:20–30.

    CAS  PubMed  Google Scholar 

  • Li, S., Liquari, P., McKee, K. K., Harrison, D., Patel, R., Lee, S., Yurchenco, P. D. (2005a) Laminin-sulfatide binding initiates basement membrane assembly and enables receptor signaling­ in Schwann cells and fibroblasts. Journal of Cellular Biology 169:179–189.

    CAS  Google Scholar 

  • Li, W. J., Tuli, R., Huang, X., Laquerriere, P., Tuan, R. S. (2005b) Multilineage differentiation of human mesenchymal stem cells in a three-dimensional nanofibrous scaffold. Biomaterials 26:5158–5166.

    CAS  PubMed  Google Scholar 

  • Litvin, J., Blagg, A., Mu, A., Matiwala, S., Montgomery, M., Berretta, R., Houser, S., Margulies, K. (2006) Periostin and periostin-like factor in the human heart: possible therapeutic targets. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 15:24–32.

    CAS  Google Scholar 

  • Lu, L., Zhu, X., Valenzuela, R. G., Currier, B. L., Yaszemski, M. J. (2001) Biodegradable polymer scaffolds for cartilage tissue engineering. Clinical Orthopaedics and Related Research 391 (Suppl):S251–S270.

    PubMed  Google Scholar 

  • Ma, G. F., Ali, A., Verzijl, N., Hanemaaijer, R., TeKoppele, J., Konttinen, Y. T., Salo, J. (2006) Increased collagen degradation around loosened total hip replacement implants. Arthritis and Rheumatism 54:2928–2933.

    PubMed  Google Scholar 

  • Maeshima,Y,, Sudhakar, A,, Lively, J. C., Ueki, K., Kharbanda, S., Kahn, C. R., Sonenberg, N., Hynes, R. O., Kalluri, R. (2002) Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science 295:140–143.

    CAS  PubMed  Google Scholar 

  • Maeshima, Y., Yerramalla, U. L., Dhanabal, M., Holthaus, K. A., Barbashov, S., Kharbanda, S., Reimer, C., Manfredi, M., Dickerson, W. M., Kalluri, R. (2001) Extracellular matrix-derived peptide binds to alpha(v)beta(3) integrin and inhibits angiogenesis. Journal of Biological Chemistry 276:31959–31968.

    CAS  PubMed  Google Scholar 

  • Maitra, N., Flink, I. L., Bahl, J. J., Morkin, E. (2000) Expression of α and β integrins during ­terminal differentiation of cardiomyocytes. Cardiovascular Research 47:715–725.

    CAS  PubMed  Google Scholar 

  • Martinez-Pomares, L., Wienke, D., Stillion, R., McKenzie, E. J., Arnold, J. N., Harris, J., McGreal, E., Sim, R. B., Isacke, C. M., Gordon, S. (2006) Carbohydrate-independent recognition of collagens by the macrophage mannose receptor. European Journal of Immunology 36:1074–1082.

    CAS  PubMed  Google Scholar 

  • Massova, I., Kotra, L. P., Fridman, R., Mobashery, S. (1998) Matrix metalloproteinases: Structure evolution and diversification. The FASEB journal: official publication of the Federation of American Societies for Experimental Biology 12:1075–1095.

    CAS  Google Scholar 

  • McKee, K. K., Harrison, D., Capizzi, S., Yurchenco, P. D. (2007) Role of laminin terminal globular domains in basement membrane assembly. Journal of Biological Chemistry 282:21437–21447.

    CAS  PubMed  Google Scholar 

  • Menasche, P. (2007) Skeletal myoblasts as a therapeutic agent. Progress in Cardiovascular Diseases 50:7–17.

    PubMed  Google Scholar 

  • Menasche, P. (2009) Cell-based therapy for heart disease: a clinically oriented perspective. Molecular therapy: the journal of the American Society of Gene Therapy 17(5):758–66.

    CAS  Google Scholar 

  • Mendelson, K., Schoen, F. J. (2006) Heart valve tissue engineering: concepts, approaches, progress, and challenges. Annals of Biomedical Engineering 34:1799–1819.

    PubMed  Google Scholar 

  • Menke, N. B., Ward, K. R., Witten, T. M., Bonchev, D. G., Diegelmann, R. F. (2007) Impaired wound healing. Clinics in Dermatology 25:19–25.

    PubMed  Google Scholar 

  • Messaritou, G., East, L., Roghi, C., Isacke, C. M., Yarwood, H. (2009) Mebrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180. Journal of Cell Science 122:4042–4048.

    CAS  PubMed  Google Scholar 

  • Mias, C., Lairez, O., Trouche, E., Roncalli, J., Calise, D., Seguelas, M. H., Ordener, C., Piercecchi-Marti, M. D., Auge, N., Salvayre, A. N., Bourin, P., Parini, A., Cussac, D. (2009) Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction. Stem Cells [Epub ahead of print].

    Google Scholar 

  • Mills, W. R., Mal, N., Kiedrowski, M. J., Unger, R., Forudi, F., Popovic, Z. B., Penn M. S., Laurita, K. R. (2007) Stem cell therapy enhances electrical viability in myocardial infarction. Journal of Molecular and Cellular Cardiology 42:314.

    Google Scholar 

  • Mizuno S, Glowacki J. (1996) Three-dimensional composite of demineralized bone powder and collagen for in vitro analysis of chondroinduction of human dermal fibroblasts. Experimental Cell Research 227:89–97.

    CAS  PubMed  Google Scholar 

  • Morais Freitas, V., Nogueira da Gama de Souza, L., Cyreno Oliveira, E., Furuse, C., Cavalcanti de Araújo, V., Gastaldoni Jaeger, R. (2007) Malignancy-related 67 kDa laminin receptor in adenoid cystic carcinoma. Effect on migration and beta-catenin expression. Oral Oncology 43:987–998.

    CAS  PubMed  Google Scholar 

  • Murphy, G., Nagase, H. (2008) Progress in matrix metalloproteinase research. Molecular Aspects of Medicine 29:290–308.

    CAS  PubMed  Google Scholar 

  • Myllyharju, J., Kivirikko, K. I. (2001) Collagens and collagen-related diseases. Annals of Medicine 33:7–21.

    CAS  PubMed  Google Scholar 

  • Naumann, A., Dennis, J. E., Awadallah, A., Carrino, D. A., Mansour, J. M., Kastenbauer, E., Caplan, A. I. (2002) Immunochemical and mechanical characterization of cartilage subtypes in rabbit. Journal of Histochemistry and Cytochemistry 50:1049–1058.

    CAS  PubMed  Google Scholar 

  • Nesselmann, C., Ma, N., Bieback, K., Wagner, W., Ho, A., Konttinen, Y. T., Zhang, H., Hinescu, M. E., Steinhoff, G. (2008) Mesenchymal stem cells and cardiac repair. Journal of Cellular and Molecular Medicine 12:1795–1810.

    CAS  PubMed  Google Scholar 

  • Nichols, J. E., Cortiella, J., Lee, J., Niles, J. A., Cuddihy, M., Wang, S., Bielitzki, J., Cantu, A., Mlcak, R., Valdivia, E., Yancy, R., McClure, M. L., Kotov, N. A. (2009) In vitro analog of human bone marrow from 3D scaffolds with biomimetic inverted colloidal crystal geometry. Biomaterials 30:1071–1079.

    CAS  PubMed  Google Scholar 

  • Nie, D. (2010) Cancer stem cell and niche. Frontiers in Biosciences 2:184–193.

    Google Scholar 

  • Nisato, R. E., Tille, J. C., Jonczyk, A., Goodman, S. L., Pepper, M. S. (2003) Alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro. Angiogenesis 6:105–119.

    CAS  PubMed  Google Scholar 

  • Nishioka, T., Suzuki, M., Onishi, K., Takakura, N., Inada, H., Yoshida, T., Hiroe, M., Imanaka-Yoshida, K. (2007) Eplerenone attenuates myocardial fibrosis in the angiotensin II-induced hypertensive mouse: involvement of tenascin-C induced by aldosterone-mediated inflammation. Journal of Cardiovascular Pharmacology 49:261–8.

    CAS  PubMed  Google Scholar 

  • Nykvist, P. (2004) Integrins as cellular receptors for fibril-forming and transmembrane collagens. Thesis work. Jyväskylä University Printing House.

    Google Scholar 

  • O’Donoghue, K., Fisk, N. M. (2004) Fetal stem cells. Best Practice & Research Clinical Obstetrics & Gynaecology 18:853–875.

    Google Scholar 

  • Ohga, S., Shikata, K., Yozai, K., Okada, S., Ogawa, D., Usui, H., Wada, J., Shikata, Y., Makino, H. (2007) Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-kappaB activation. American Journal of Physiology - Renal Physiology 292:F1141-F1150.

    CAS  PubMed  Google Scholar 

  • Park, J. B., Lakes, R. S. (1992) Biomaterials: An Introduction. Plenum: New York.

    Google Scholar 

  • Parks, W. C., Wilson, C. L., Lopez-Boado, Y. S. (2004) Matrix metalloproteinases as modulators of inflammation and innate immunity. Nature Reviews. Immunology 4:617–629.

    CAS  PubMed  Google Scholar 

  • Patarroyo, M., Tryggvason, K., Virtanen, I. (2002) Laminins in tumor invasion, angiogenesis and metastasis. Seminars in Cancer Biology 12:197–207.

    CAS  PubMed  Google Scholar 

  • Paweletz, N., Knierim, M. (1989) Tumor related angiogenesis. Critical Reviews in Oncology/Hematology 9:197–242.

    CAS  PubMed  Google Scholar 

  • Penn, M. S., Mangi, A. A. (2008) Genetic enhancement of stem cell engraftment, survival, and efficacy. Circulation Research 102(12):1471–82.

    CAS  PubMed  Google Scholar 

  • Perna, A. M., Masini, E., Nistri, S., Bani, S. T., Bigazzi, M., Bani, D. (2005) Human recombinant relaxin reduces heart injury and improves ventricular performance in a swine model of acute myocardial infarction. Annals of the New York Academy of Sciences 1041:431–433.

    CAS  PubMed  Google Scholar 

  • Pommerenke, H., Schreiber, E., Dürr, F., Nebe, B., Möller, W., Rychly, J. (1996) Stimulation of integrin receptors using a magnetic drag force device induces an intracellular free calcium response. European Journal of Cell Biology 70:157–164.

    CAS  PubMed  Google Scholar 

  • Poole, C. A. (1992) Chondrons, the chondrocyte and its pericellular microenvironment. In: Kuettner, K. E., Schleyerbach, R, Peyron, J. G., Hascall, V. C. Articular Cartilage and Osteoarthritis, New York: Raven, 201–220.

    Google Scholar 

  • Rabinovich, G. A., Rubinstein, N., Toscano, M.A. (2002) Role of galectins in inflammatory and immunomodulatory processes. Biochimica et Biophysica Acta 1572:274–284.

    CAS  PubMed  Google Scholar 

  • Ramsay, A. G., Marshall, J. F., Hart, I. R. (2007) Integrin trafficking and its role in cancer metastasis. Cancer Metastasis Reviews 26:567–578.

    CAS  PubMed  Google Scholar 

  • Reichenberger, E., Baur, S., Sukotjo, C., Olsen, B. R., Karimbux, N. Y., Nishimura, I. (2000) Collagen XII mutation disrupts matrix structure of periodontal ligament and skin. Journal of Dental Research 79:1962–1968.

    CAS  Google Scholar 

  • Rho, J. Y., Kuhn-Spearing, L., Zioupos, P. (1998) Mechanical properties and the hierarchical structure of bone. Medical Engineering & Physics 20:92–102.

    CAS  Google Scholar 

  • Ries, C., Egea, V., Karow, M., Kolb, H., Jochum, M., Neth, P. (2007) MMP-2, T1-MMP, and TIMP-2 are essential for the invasive capacity of human esenchymal stem cells: Differential regulation by inflammatory cytokines. Blood 109:4055–4063.

    CAS  PubMed  Google Scholar 

  • Risteli, J., Bachinger, H. P., Engel, J., Furthmayr, H., Timpl, R. (1980) 7-S collagen: characterization of an unusual basement membrane structure. European Journal of Biochemistry 108:239–250.

    CAS  PubMed  Google Scholar 

  • Robles, D. T. and Berg, D. (2007) Abnormal wound healing: keloids. Clinics in Dermatology 25:26–32.

    PubMed  Google Scholar 

  • Roell, W., Lewalter, T., Sasse, P., Tallini, Y. N., Choi, B. R., Breitbach, M., Doran, R., Becher, U. M., Hwang, S. M., Bostani, T., von Maltzahn, J., Hofmann, A., Reining, S., Eiberger, B., Gabris, B., Pfeifer, A., Welz, A., Willecke, K., Salama, G., Schrickel, J. W., Kotlikoff, M. I., Fleischmann, B. K. (2007) Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia. Nature 450:819–824.

    CAS  PubMed  Google Scholar 

  • Rüster, B., Göttig, S., Ludwig, R. J., Bistrian, R., Müller, S., Seifried, E., Gille, J., Henschler, R. (2006) Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells. Blood 108:3938–3944.

    PubMed  Google Scholar 

  • Sacks, M. S., Yoganathan, A. P. (2007) Heart valve function: a biomechanical perspective. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 362:1369–1391.

    PubMed  Google Scholar 

  • Sasaki, K., Takagi, M., Konttinen, Y. T., Sasaki, A., Tamaki, Y., Ogino, T., Santavirta, S., Salo, J. (2007) Upregulation of matrix metalloproteinase (MMP)-1 and its activator MMP-3 of human osteoblast by uniaxial cyclic stimulation. Journal of Biomedical Materials Research Part B: Applied Biomaterials 80:491–498.

    Google Scholar 

  • Sato, A., Aonuma, K., Imanaka-Yoshida, K., Yoshida, T., Isobe, M., Kawase, D., Kinoshita, N., Yazaki, Y., Hiroe, M. (2006) Serum tenascin-C might be a novel predictor of left ventricular remodeling and prognosis after acute myocardial infarction. Journal of the American College of Cardiology 47:2319–2325.

    CAS  PubMed  Google Scholar 

  • Schultz, G. S., Ladwig, G., Wysocki, A. (2005) Extracellular matrix: Review of itsroles in acute and chronic wounds. World Wide Wounds. www.worldwidewounds.com/2005/august/Schultz/Extrace-Matric-Acute-Chronic-Wounds.html

  • Sekiya, I., Colter, D. C., Prockop, D. J. (2001) BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells. Biochemical and Biophysical Research Communications 284:411–418.

    CAS  PubMed  Google Scholar 

  • Shanbhag, S., Woo Lee, J., Kotov, N. (2005) Diffusion in three-dimensionally ordered scaffolds with inverted colloidal crystal geometry. Biomaterials 26:5581–5585.

    CAS  PubMed  Google Scholar 

  • Shimaoka, M., Takagi, J., Springer, T. A. (2002) Conformational regulation of integrin structure and function. Annual Review of Biophysics and Biomolecular Structure 31:485–516.

    CAS  PubMed  Google Scholar 

  • Shimazaki, M., Nakamura, K., Kii, I., Kashima, T., Amizuka, N., Li, M., Saito, M., Fukuda, K., Nishiyama, T., Kitajima, S., Saga, Y., Fukayama, M., Sata, M., Kudo, A. (2008) Periostin is essential for cardiac healing after acute myocardial infarction. The Journal of Experimental Medicine 205:295–303.

    CAS  PubMed  Google Scholar 

  • Shintani, Y., Fukumoto, Y., Chaika, N., Svoboda, R., Wheelock, M. J., Johnson, K. R. (2008) Collagen I-mediated upregulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor I. The Journal of Cell Biology 180:1277–1289.

    CAS  PubMed  Google Scholar 

  • Silva, R., D’Amico, G., Hodivala-Dilke, K. M., Reynolds, L. E. (2008) Integrins. The keys to unlocking angiogenesis. Arterioscleroris, Thrombosis and Vascular Biology 28:1703–1713.

    CAS  Google Scholar 

  • Solchaga, L. A., Goldberg, V. M., Caplan, A. I. (2001) Cartilage regeneration using principles of tissue engineering. Clinical Orthopaedics and Related Research 391S:S161–S170.

    Google Scholar 

  • Steffensen, B., Häkkinen, L., Larjava, H. (2001) Proteolytic events of wound-healing – coordinated intractions among matrix metalloproteinases (MMPs), integrins, and extracellular matrix molecules. Critical Reviews in Oral Biology & Medicine 12:373–398.

    CAS  Google Scholar 

  • Steingen, C., Brenig, F., Baumgartner, L., Schmidt, J., Schmidt, A., Bloch, W. (2008) Characterization of key mechanisms in transmigration and invasion of mesenchymal stem cells. Journal of Molecular and Cellular Cardiology 44:1072–1084.

    CAS  PubMed  Google Scholar 

  • Steinmeyer, J., Konttinen, Y. T. (2006) Oral treatment options for degenerative joint disease – presence and future. Advanced Drug Delivery Reviews 58:168–211.

    CAS  PubMed  Google Scholar 

  • Sun, M., Opavsky, A., Stewart, D. J., Rabinovtich, M., Dawood, F., Wen, W. H., Liu, P. P. (2003) Temporal response and localization of integrins beta-1 and beta-2 in the heart following myocardial infarction: Regulation by cytokines. Circulation 107:1046–1052.

    CAS  PubMed  Google Scholar 

  • Sund, M., Ylönen, R., Tuomisto, A., Sormunen, R., Tahkola, J., Kvist, A. P., Kontusaari, S., Autio-Harmainen, H., Pihlajaniemi, T. (2001) Abnormal adherence junctions in the heart and reduced angiogenesis in transgenic mice overexpressing mutant type XIII collagen. EMBO Journal 20:5153–5164.

    CAS  PubMed  Google Scholar 

  • Sunk, I. G., Bobacz, K., Hofstaetter, J. G., Amoyo, L., Soleiman, A., Smolen, J., Xu, L., Li, Y. (2007) Increased expression of discoidin domain receptor 2 is linked to the degree of cartilage damage in human knee joints: a potential role in osteoarthritis pathogenesis. Arthritis and Rheumatism 56:3685–3692.

    CAS  PubMed  Google Scholar 

  • Takagi, M. (1996) Neutral proteinases and their inhibitors in the loosening of total hip prosthesis. Acta Orthopaedica Scandinavica 67 (Suppl 271):1–29.

    Google Scholar 

  • Tamaoki, M., Imanaka-Yoshida, K., Yokoyama, K., Nishioka, T., Inada, H., Hiroe, M., Sakakura, T., Yoshida, T. (2005) Tenascin-C regulates recruitment of myofibroblasts during tissue repair after myocardial injury. The American Journal of Pathology 167:71–80.

    CAS  PubMed  Google Scholar 

  • Taylor, D. (2007) Fracture and repair of bone: a multiscale problem. Journal of Materials Science 42:8911–8918.

    CAS  Google Scholar 

  • Tzu, J., Marinkovich, M. P. (2008) Bridging structure with function: structural, regulatory, and developmental role of laminins. International Journal of Biochemistry & Cell Biology 40:199–214.

    CAS  Google Scholar 

  • Uygun, B. E., Stojsih, S. E., Matthew, H. W. (2009) Effects of immobilized glycosaminoglycans on the proliferation and differentiation of mesenchymal stem cells. Tissue Engeneering Part A 15:3499–3512.

    CAS  Google Scholar 

  • van der Kraan, P. M., Buma, P., van Kuppevelt, T., van den Berg, W. B. (2002) Interaction of chondrocytes, extracellular matrix and growth factors: relevance for articular cartilage tissue engineering. Osteoarthritis Cartilage 10:631–637.

    PubMed  Google Scholar 

  • van Osch, G. J., Brittberg, M., Dennis, J. E., Bastiaansen-Jenniskens, Y. M., Erben, R. G., Konttinen, Y. T., Luyten, F. P. (2009) Cartilage repair: past and future – lessons for regenerative medicine. Journal of Cellular and Molecular Medicine 13:792–810.

    PubMed  Google Scholar 

  • Veilleux, N., Spector, M. (2005) Effects of FGF-2 and IGF-1 on adult canine articular chondrocytes in type II collagen-glycosaminoglycan scaffolds in vitro. Osteoarthritis and Cartilage 13:278–286.

    CAS  PubMed  Google Scholar 

  • Veit, G., Kobbe, B., Keene, D. R., Paulsson, M., Koch, M., Wagener, R. (2006) Collagen XXVIII, a novel von Willebrand factor A domain-containing protein with many imperfections in the collagenous domain. Journal of Biological Chemistry 281:3494–3504.

    CAS  PubMed  Google Scholar 

  • Visse, R., Nagase, H. (2003) Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circulation Research 92:827–839.

    CAS  PubMed  Google Scholar 

  • Vuoristo, S., Virtanen, I., Takkunen, M., Palgi, J., Kikkawa, Y., Rousselle, P., Sekiguchi, K., Tuuri, T., Otonkoski, O. (2009) Laminin isoforms in human embryonic stem cells: synthesis, receptor usage and growth support. Journal of Cellular and Molecular Medicine 13:2622–2633.

    Google Scholar 

  • Wakitani, S., Goto, T., Pineda, S. J., Young, R. G., Mansour, J. M., Caplan, A. I., Goldberg, V. M. (1994) Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. Journal of Bone and Joint Surgery, American volume 76:579–592.

    CAS  Google Scholar 

  • Warden, S., Zaleske, D. J., Glowacki, J. (2004) Fate of a chimeric joint construct in an ectopic site in SCID mice. Cell Transplantation 13:161–168.

    PubMed  Google Scholar 

  • Weckroth, M., Vaheri, A., Lauharanta, J., Sorsa, T., Konttinen, Y. T. (1996) Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers. J Invest Dermatol 106:1119–1124.

    CAS  PubMed  Google Scholar 

  • Wienke, D., MacFadyen, J. R., Isacke, C. M. (2003) Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor. Molecular Biology of the Cell 14:3592–3604.

    CAS  PubMed  Google Scholar 

  • Wu, Y., Ip, J. E., Huang, J., Zhang, L., Matsushita, K., Liew, C. C., Pratt, R. E., Dzau, V. J. (2006) Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. Circulation Research 99:315–322.

    CAS  PubMed  Google Scholar 

  • Wu M, Wu ZF, Merajver SD (2007). Rho proteins and cell-matrix interactions in cancer. Cells Tissues Organs 185:100–103.

    CAS  PubMed  Google Scholar 

  • Xian, X., Gopal, S., Couchman, J. R. (2010) Syndecans as receptors and organizers of the extracellular matrix. Cell and Tissue Research 339:31–46.

    CAS  PubMed  Google Scholar 

  • Xiang, G., Schuster, M. D., Seki, T., Kocher, A. A., Eshghi, S., Boyle, A., Itescu, S. (2004) Down-regulation of plasminogen activator inhibitor 1 expression promotes myocardial neovascularization by bone marrow progenitors. The Journal of Experimental Medicine 200:1657–1666.

    CAS  PubMed  Google Scholar 

  • Xiang, G., Schuster, M. D., Seki, T., Witkowski, P., Eshghi, S., Itescu, S. (2005) Downregulated expression of plasminogen activator inhibitor-1 augments myocardial neovascularization and reduces cardiomyocyte apoptosis after acute myocardial infarction. Journal of the American College of Cardiology 46:536–541.

    CAS  PubMed  Google Scholar 

  • Yates, K. E., Allemann, F., Glowacki, J. (2005) Phenotypic analysis of bovine chondrocytes cultured in 3D collagen sponges: effect of serum substitutes. Cell and Tissue Bank 6:45–54.

    CAS  Google Scholar 

  • Yilmaz, M., Christofori, G. (2009) EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Reviews 28:15–33.

    PubMed  Google Scholar 

  • Yozai, K., Shikata, K., Sasaki, M., Tone, A., Ohga, S., Usui, H., Okada, S., Wada, J., Nagase, R., Ogawa, D., Shikata, Y., Makino, H. (2005) Methotrexate prevents renal injury in experimental diabetic rats via anti-inflammatory actions. Journal of the American Society of Nephrology 16:3326–3338.

    CAS  PubMed  Google Scholar 

  • Zhao, S., Wehner, R., Bornhäuser, M., Wassmuth, R., Bachmann, M., Schmitz, M. (2009) Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders. Stem Cells and Development Oct 13 [Epub ahead of print].

    Google Scholar 

  • Zhou, J., Ding, M., Zhao, Z., Reeders, S. T. (1994) Complete primary structure of the sixth chain of human basement membrane collagen, alpha 6(IV). Isolation of the cDNAs for alpha 6(IV) and comparison with five other type IV collagen chains. Journal of Biological Chemistry 269:13193–13199.

    CAS  PubMed  Google Scholar 

  • Zimmermann, W. H., Didié, M., Wasmeier, G. H., Nixdorff, U., Hess, A., Melnychenko, I., Boy, O., Neuhuber, W. L., Weyand, M., Eschenhagen, T. (2002) Cardiac grafting of engineered heart ­tissue in syngenic rats. Circulation 106 (12 Suppl 1):I1151–1157

    Google Scholar 

Download references

Aknowledgements

This work was supported EU Matera grant “Bioactive Nanocomposite Constructs for Regeneration of Articular Cartilage”, European Science Foundation “Regenerative Medicine” RNP, Danish Council for Strategic Research, Finska Läkaresällskapet, Orion Foundation and EU COST 533 Biotribology Action.

Author information

Authors and Affiliations

  1. Department of Medicine, Institute of Clinical Medicine, Haartmaninkatu 8, 00029 HUS, Helsinki, Finland

    Yrjö T. Konttinen, Emilia Kaivosoja, Vasily Stegaev & Jaakko Levón

  2. COXA Hospital for Joint Replacement, Biokatu 6 b, 33520, Tampere, Finland

    Yrjö T. Konttinen

  3. ORTON Orthopaedic Hospital, ORTON Foundation, Tenholantie 10, 00280, Helsinki, Finland

    Yrjö T. Konttinen & Veli-Matti Tiainen

  4. Department of Histology and Embryology, Medical University of Bialystok, G.Washington Street 13, 15-269, Bialystok, Poland

    Zygmunt Mackiewicz

  5. Department of Materials and Interfaces, Weizmann Institute of Science, 76100, Rehovot, Israel

    H. Daniel Wagner

Authors
  1. Yrjö T. Konttinen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Emilia Kaivosoja
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Vasily Stegaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Daniel Wagner
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jaakko Levón
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Veli-Matti Tiainen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Zygmunt Mackiewicz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yrjö T. Konttinen .

Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Herzchirurgie, Universitätsklinikum Rostock, Schillingallee 35, Rostock, 18057, Germany

    Gustav Steinhoff

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Netherlands

About this chapter

Cite this chapter

Konttinen, Y.T. et al. (2011). Extracellular Matrix and Tissue Regeneration. In: Steinhoff, G. (eds) Regenerative Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9075-1_2

Download citation

Publish with us

Policies and ethics

Search

Navigation