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Inhibitors of Innate Immunity from Vaccinia Virus

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The Challenge of Highly Pathogenic Microorganisms

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Abstract

Vaccinia virus (VACV) is an enigma, for it is the only vaccine to have eradicated a human disease, smallpox, and yet its origin and natural host remain unknown. After the eradication of smallpox, VACV has continued to be studied intensively because of the potential use of recombinant VACVs as vaccines against other infectious diseases, and because it is an excellent model for studying virus-host interactions. This short article considers some of the strategies used by VACV to suppress the host innate immune response to infection. These strategies include proteins that are secreted from infected cells to bind complement factors, cytokines, chemokines or interferons, and intracellular proteins that can synthesize steroid hormones, or block apoptosis or innate signalling pathways leading to production of inflammatory mediators.

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Acknowledgements

The author is most grateful to the conference organisers for the kind invitation to visit Israel and attend the 46th Oholo Conference. The work in the author’s laboratory has been supported by grants from the Wellcome Trust, the Medical Research Council of UK. GLS is a Wellcome Principal Research Fellow.

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Authors and Affiliations

  1. Department of Virology, Faculty of Medicine, Imperial College London, St. Mary’s Campus, Norfolk Place, London, W2 1PG, England

    Geoffrey L. Smith (Faculty of Medicine)

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  1. Geoffrey L. Smith
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Correspondence to Geoffrey L. Smith .

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Editors and Affiliations

  1. Israel Institute for Biological Research, Ness-Ziona, 74100, Israel

    Avigdor Shafferman

  2. Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona, 74100, Israel

    Arie Ordentlich

  3. Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona, 74100, Israel

    Baruch Velan

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Smith, G.L. (2010). Inhibitors of Innate Immunity from Vaccinia Virus. In: Shafferman, A., Ordentlich, A., Velan, B. (eds) The Challenge of Highly Pathogenic Microorganisms. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9054-6_13

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