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Polyelectrolyte Complexes as Smart Nanoengineered Systems for Biotechnology and Gene Delivery

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Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles

Abstract

Preparation and properties of water-soluble non-stoichiometric polyelectrolyte complexes are described. It is demonstrated that the data accumulated on studying kinetics and equilibrium of competitive reactions in solutions of the complexes form a basis for the development of stimuli responsive polyelectrolyte systems that are used for (bio)separation, gene delivery, immunoassay, design of (oligomeric) enzymes with controlled thermoaggregation and thermostability, preparation of ultrathin multilayered polyelectrolyte films and hollow capsules, creation of artificial chaperones.

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Authors and Affiliations

  1. Polymer Chemistry Department, Moscow State University, Leninskiye Gory, Moscow, 119991, Russia

    Vladimir A. Izumrudov

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  1. Vladimir A. Izumrudov
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  1. Inst. Makromolekulare Chemie, Zentrum für Biologische Signalstudien, Universität Freiburg, Stefan-Meier-Str. 31, Freiburg, 79104, Germany

    Venkatram Prasad Shastri

  2. Avançats (ICREA), Instituciò Catalana de Recerca i Estudis, Feixa Llarga s/n, L'Hospitalet de Llobregat, 08907, Spain

    George Altankov

  3. Geesthacht GmbH, Institut für Chemie, GKSS Forschungszentrum, Kantstraße 5, Teltow, 14513, Germany

    Andreas Lendlein

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Izumrudov, V.A. (2010). Polyelectrolyte Complexes as Smart Nanoengineered Systems for Biotechnology and Gene Delivery. In: Shastri, V., Altankov, G., Lendlein, A. (eds) Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8790-4_18

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