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Chemical and Physical Modifications of Biomaterial Surfaces to Control Adhesion of Cells

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Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles

Abstract

Cell adhesion is a prerequisite for healing of implant materials and colonization of tissue engineering scaffolds. Hence, it is a crucial task to control adhesion of cells on biomaterials, which can be achieved by surface modification. Different techniques can be used to modify the surface of materials, which have the desired physical and chemical properties, but lack sufficient biocompatibility. Among the techniques of surface modification, a number of self assembly methods have the advantage to work in solutions, so that different shaped materials can be modified easily. Self assembly methods selected in this study were chemisorption and covalent binding of alkylsiloxanes on glass (i), photochemical binding of polyethylene glycol on hydrophobic polymers (ii) and alternating adsorption of polyanions and polycations to assemble nanostructured multilayers on charged surfaces (iii). These methods enable to obtain control on adhesion of cells on different classes of biomaterials, which eventually may promote subsequent processes like cell growth and differentiation.

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Acknowledgments

A part of the results presented here is based on contributions from previous projects and co-operations with Mathias Ulbricht, University Essen-Duisburg and Volkmar Thom, Sartorius AG. Financial support for these studies was provided by Deutsche Forschungsgemeinschaft (Gr 1290/4-1 and Gr 1290/4-2) and European Union funded Marie-Curie-Fellowships to George Altankov (HPMF-CT-2001-01275), Nathalie Faucheux (HPMF-CT-2000-00883) and Zhen-Mei Liu (MIF1-CT2005-021845).

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Authors and Affiliations

  1. Biomedical Materials Group, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, 06120, Halle (Saale), Germany

    Thomas Groth, Zhen-Mei Liu, Marcus Niepel, Dieter Peschel & Kristin Kirchhof

  2. ICREA & Institute of Bioengineering Catalunya, Barcelona, Spain

    George Altankov

  3. Chemical Engineering Department, University of Sherbrooke, Sherbrooke, Canada

    Nathalie Faucheux

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  1. Thomas Groth
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  2. Zhen-Mei Liu
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Correspondence to Thomas Groth .

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  1. Inst. Makromolekulare Chemie, Zentrum für Biologische Signalstudien, Universität Freiburg, Stefan-Meier-Str. 31, Freiburg, 79104, Germany

    Venkatram Prasad Shastri

  2. Avançats (ICREA), Instituciò Catalana de Recerca i Estudis, Feixa Llarga s/n, L'Hospitalet de Llobregat, 08907, Spain

    George Altankov

  3. Geesthacht GmbH, Institut für Chemie, GKSS Forschungszentrum, Kantstraße 5, Teltow, 14513, Germany

    Andreas Lendlein

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Groth, T. et al. (2010). Chemical and Physical Modifications of Biomaterial Surfaces to Control Adhesion of Cells. In: Shastri, V., Altankov, G., Lendlein, A. (eds) Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8790-4_13

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