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Function of TopBP1 in Genome Stability

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Genome Stability and Human Diseases

Part of the book series: Subcellular Biochemistry ((SCBI,volume 50))

Abstract

Human DNA topoisomerase IIβ-binding protein 1 (TopBP1) and its orthologues in other organisms are proteins consisting of multiple BRCT modules that have acquired several functions during evolution. These proteins execute their tasks by interacting with a great variety of proteins involved in nuclear processes. TopBP1 is an essential protein that has numerous roles in the maintenance of the genomic integrity. In particular, it is required for the activation of ATM and Rad3-related (ATR), a vital regulator of DNA replication and replication stress response. The orthologues from yeast to human are involved in DNA replication and DNA damage response, while only proteins from higher eukaryotes are also involved in complex regulation of transcription, which is related to cell proliferation, damage response and apoptosis. We review here the recent progress in research aimed at elucidating the multiple cellular functions of TopBP1, focusing on metazoan systems.

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Acknowledgements

We would like to thank Frank Hänel for his help on Fig. 4.

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Authors and Affiliations

  1. Faculty of Biosciences, University of Joensuu, FI-80101, Joensuu, Finland

    Miiko Sokka, Sinikka Parkkinen, Helmut Pospiech & Juhani E. Syväoja

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  1. Miiko Sokka
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  2. Sinikka Parkkinen
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  3. Helmut Pospiech
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  4. Juhani E. Syväoja
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  1. Galway, Ireland

    Heinz-Peter Nasheuer

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Sokka, M., Parkkinen, S., Pospiech, H., Syväoja, J.E. (2010). Function of TopBP1 in Genome Stability. In: Nasheuer, HP. (eds) Genome Stability and Human Diseases. Subcellular Biochemistry, vol 50. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3471-7_7

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