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Specific Mechanotransduction Signaling Involved in Myogenic Responses of the Cerebral Arteries

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Mechanosensitivity of the Heart

Part of the book series: Mechanosensitivity in Cells and Tissues ((MECT,volume 3))

Abstract

The cerebral artery is known to be particularly sensitive to mechanoreception in the form of blood pressure, blood flow, and other hemodynamic forces. Stretching and intraluminal pressurization, which might mimic an acute and/or chronic change in blood pressure, induce many different responses, including contraction, activation of various kinases and ionic channels, production of various vasoactive substances, gene expression, and phenotype changes. Here, we briefly discuss specific mechanotransduction signaling pathways involved in the myogenic responses of cerebral arteries. We emphasize that it is important to recognize mechanical forces and control them not only to improve our knowledge of cardiovascular system in physiologic and pathophysiologic conditions but also for the development of new therapeutic drugs.

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Acknowledgements

The present study was supported in part by grants-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and by grants from the Shizuoka Research and Development Foundation. We also appreciate Iwate Medical University and University of Shizuoka for their continuous support.

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Authors and Affiliations

  1. Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Iwate Medical University, 028-3694, Yahaba, Iwate, Japan

    Koichi Nakayama

  2. Department of Pharmacology School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka City, Shizuoka, Japan

    Kazuo Obara & Tomohisa Ishikawa

  3. Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan

    Shigeru Nishizawa

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  1. Koichi Nakayama
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  2. Kazuo Obara
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  4. Shigeru Nishizawa
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Correspondence to Koichi Nakayama .

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  1. Dept. Fundamental &, Russian State Medical University, Ostrovitjanova Str. 1, Moskva, 117997, Russian Federation

    Andre Kamkin

  2. Dept. Fundamental &, Russian State Medical University, Ostrovitjanova Str. 1, Moskva, 117997, Russian Federation

    Irina Kiseleva

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© 2010 Springer Science+Business Media B.V.

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Nakayama, K., Obara, K., Ishikawa, T., Nishizawa, S. (2010). Specific Mechanotransduction Signaling Involved in Myogenic Responses of the Cerebral Arteries. In: Kamkin, A., Kiseleva, I. (eds) Mechanosensitivity of the Heart. Mechanosensitivity in Cells and Tissues, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2850-1_17

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