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Functions of SUMO in the Maintenance of Genome Stability

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SUMO Regulation of Cellular Processes

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Abstract

Like in most other areas of cellular metabolism, the functions of the ubiquitin-like modifier SUMO in the maintenance of genome stability are manifold and varied. Perturbations of global sumoylation cause a wide spectrum of phenotypes associated with defects in DNA maintenance, such as hypersensitivity to DNA-damaging agents, gross chromosomal rearrangements and loss of entire chromosomes. Consistent with these observations, many key factors involved in various DNA repair pathways have been identified as SUMO substrates. However, establishing a functional connection between a given SUMO target, the cognate SUMO ligase and a relevant phenotype has remained a challenge, mainly because of the difficulties involved in identifying important modification sites and downstream effectors that specifically recognize the target in its sumoylated state. This review will discuss selected examples of SUMO’s actions in several DNA repair and genome maintenance pathways where the biological consequences of the modification have been elucidated.

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Abbreviations

ALT::

alternative lengthening of telomeres

BLM::

Bloom’s syndrome helicase

dsDNA::

double-stranded DNA

HU::

hydroxyurea

MEF::

mouse embryonic fibroblast

MMS::

Methyl methanesulfonate

PCNA::

proliferating cell nuclear antigen

PML::

promyelocytic leukaemia

rDNA::

ribosomal DNA

RING::

really interesting new gene

SIM::

SUMO interacting motif

SMC::

structural maintenance of chromosomes

ssDNA::

single-stranded DNA

TDG::

thymidine DNA glycosylase

WRN::

Werner’s syndrome helicase

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Acknowledgement

Our work is supported by a predoctoral fellowship from the Boehringer Ingelheim Foundation (to N. Z.) and by Cancer Research UK.

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  1. Clare Hall Laboratories, Cancer Research UK London Research Institute, EN6 3LD, Blanche Lane, South Mimms, UK

    Nicola Zilio & Helle D. Ulrich

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  1. Nicola Zilio
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  2. Helle D. Ulrich
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Correspondence to Helle D. Ulrich .

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  1. College Station, 77843-1114, U.S.A.

    Van G. Wilson

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Zilio, N., Ulrich, H.D. (2009). Functions of SUMO in the Maintenance of Genome Stability. In: Wilson, V. (eds) SUMO Regulation of Cellular Processes. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2649-1_5

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