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SUMO Modification and Transcriptional Regulation

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SUMO Regulation of Cellular Processes

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Abstract

Transcriptional regulation is a complex multistep process involving numerous protein-protein and protein nucleic acid interactions influenced by post-translational modifications. Both sequence specific DNA binding factors as well as coregulator proteins are targets of sumoylation, and many of the paradigms for SUMO-mediated effects have been identified in the context of transcriptional regulation. Although SUMO modification is most commonly associated with transcriptional repression, it is now evident that this modification is utilized in multiple contexts to regulate the assembly, function and disassembly of multiprotein and nucleic acid transcription complexes. By focusing on specific DNA binding factors and their coregulators, the goal of this chapter is to provide representative examples that illustrate the pervasive and dramatic influence of sumoylation on transcriptional regulation and provide insights on the underlying mechanisms and factors involved.

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Acknowledgments

The author acknowledges the many research groups that have contributed significantly to the field but could not be specifically mentioned due to space limitations. Thanks are also extended to present and former members of the author’s research group, which is supported by United States Public Health Service Grant DK61656.

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  1. Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA

    Jorge A. Iñiguez-Lluhí

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    Van G. Wilson

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Iñiguez-Lluhí, J.A. (2009). SUMO Modification and Transcriptional Regulation. In: Wilson, V. (eds) SUMO Regulation of Cellular Processes. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2649-1_2

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