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Neurofysiologische aspecten van DBS

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Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen

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Samenvatting

Bij diepe hersenstimulatie (‘deep brain stimulation’, DBS) worden verschillende neurofysiologische technieken gebruikt, hetzij voor betere lokalisatie van het DBS-doel, hetzij om meer te weten te komen over de elektrische signalen van de neuronen ter plekke van het DBS-doel. Het gaat dan om registratie van de elektrische signalen van de neuronen, die uit hun vuurpatronen kunnen bestaan. Dit gebeurt met zeer kleine naaldjes en heet ‘microelectrode recording’ (MER). Ook is het mogelijk met grotere elektroden de gezamenlijke activiteit van een ensemble van neuronen te meten en dit heet dan ‘local field potential’ (LFP-)recording. Een andere neurofysiologische techniek is het uitvoeren van een proefstimulatie tijdens de DBS-operatie, om de optimale plaats voor de stimulatie-elektrode vast te stellen. De afgelopen jaren zijn deze technieken steeds meer verfijnd en zij behoren nu tot het standaardinstrumentarium van de klinisch neurofysioloog die betrokken is bij DBS.

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Author information

Authors and Affiliations

  1. Afdeling Neurofysiologie, Academisch Medisch Centrum (AMC), Amsterdam, The Netherlands

    Lo Bour

  2. Afdeling Klinische Neurofysiologie, Maastricht UMC+, Maastricht, The Netherlands

    Vivianne van Kranen-Mastenbroek

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  1. Lo Bour
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  2. Vivianne van Kranen-Mastenbroek
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Editor information

Editors and Affiliations

  1. Maastricht University Medical Cente Department of Neurosurgery, Maastricht, The Netherlands

    Y. Temel

  2. Dept. Of Psychiatry, Maastricht Univeristy Medical Centre, Maastricht, The Netherlands

    A.F.G. Leentjens

  3. Afd. Neurologie, Amsterdam Medisch Centrum, Amsterdam, The Netherlands

    R.M.A. de Bie

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© 2016 Bohn Stafleu van Loghum

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Bour, L., van Kranen-Mastenbroek, V. (2016). Neurofysiologische aspecten van DBS. In: Temel, Y., Leentjens, A., de Bie, R. (eds) Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen. Bohn Stafleu van Loghum, Houten. https://doi.org/10.1007/978-90-368-0959-7_5

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  • DOI: https://doi.org/10.1007/978-90-368-0959-7_5

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  • Publisher Name: Bohn Stafleu van Loghum, Houten

  • Print ISBN: 978-90-368-0958-0

  • Online ISBN: 978-90-368-0959-7

  • eBook Packages: Dutch language eBook collection

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