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Diepe hersenstimulatie bij verslaving

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Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen

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Samenvatting

Afhankelijkheid van psychoactieve middelen is een moeilijk te behandelen aandoening. Het terugvalpercentage is dan ook erg hoog. Deze psychiatrische conditie heeft een belangrijke impact op de lichamelijke gezondheid en het sociaaleconomisch functioneren van patiënten en gaat gepaard met cognitieve tekorten. In het ontstaan en de evolutie van verslaving speelt het beloningssysteem een cruciale rol. De huidige beschikbare therapeutische mogelijkheden lijken evenwel onvoldoende. Vanwege het modulerend effect in neuronale circuits zou diepe hersenstimulatie (‘deep brain stimulation’, DBS) een gunstig effect op therapieresistente afhankelijkheid kunnen hebben. Verder onderzoek naar effectiviteit, werkingsmechanisme en stimulatieparameters is echter noodzakelijk. Richtlijnen dienen uitgewerkt te worden.

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Literatuur

  1. American Psychiatric Association. Diagnostic and statisical manual of mental disorders (DSM-5). 5th ed. Washington: American Psychiatric Publishing; 2013.

    Book  Google Scholar 

  2. George O, Koob GF. Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neurosci Biobehav Rev. 2010;35:232–47.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Hyman SE, Malenka RC. Addiction and the brain: the neurobiology of compulsion and its persistence. Nat Rev Neurosci. 2001;2:695–703.

    Article  CAS  PubMed  Google Scholar 

  4. Deserno L, Beck A, Huys QJ, Lorenz RC, Buchert R, Buchholz H, et al. Chronic alcohol intake abolishes the relationship between dopamine synthesis capacity and learning signals in the ventral striatum. Eur J Neurosci. 2015;41:477–86.

    Article  PubMed  Google Scholar 

  5. Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology. 2010;35:217–38.

    Article  PubMed  Google Scholar 

  6. Heinz A, Beck A, Grüsser SM, Grace AA, Wrase J. Identifying the neural circuitry of alcohol craving and relapse vulnerability. Addict Biol. 2009;14:108–18.

    Article  CAS  PubMed  Google Scholar 

  7. Gardner EL. Addiction and brain reward and antireward pathways. Adv Psychosom Med. 2011;30:22–60.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Jonas DE, Amick HR, Feltner C, Bobashev G, Thomas K, Wines R, et al. Pharmacotherapy for adults with alcohol use disorders in outpatient settings: A systematic review and meta-analysis. JAMA. 2014;311:1889–900.

    Article  PubMed  Google Scholar 

  9. Nutt DJ. The role of the opioid system in alcohol dependence. J Psychopharmacol. 2014;28:8–22.

    Article  PubMed  Google Scholar 

  10. Jansen JM, Daams JG, Koeter MWJ, Veltman DJ, Brink W van den, Goudriaan AE. Effects of non-invasive neurostimulation on craving: a meta-analysis. Neurosci Biobehav Rev. 2013;37:2472–80.

    Google Scholar 

  11. Herremans SC, Baeken C. The current perspective of neuromodulation techniques in the treatment of alcohol addiction: a systematic review. Psychiatr Danubina. 2012;24(Suppl. 1):14–20.

    Google Scholar 

  12. Feil J, Zangen A. Brain stimulation in the study and treatment of addiction. Neurosci Biobehav Rev. 2010;34:559–74.

    Article  PubMed  Google Scholar 

  13. Gorelick DA, Zangen A, George MS. Transcranial magnetic stimulation in the treatment of substance addiction. Ann N Y Acad Sci. 2014;1327:79–93.

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Guercio LA, Schmidt HD, Pierce RC. Deep brain stimulation of the nucleus accumbens shell attenuates cue-induced reinstatement of both cocaine and sucrose seeking rats. Behav Brain Res. 2015;15(281):125–30.

    Article  Google Scholar 

  15. Hamilton J, Lee J, Canales JJ. Chronic unilateral stimulation of the nucleus accumbens at high or low frequencies attenuates relapse to cocaine seeking in an animal model. Brain Stimul. 2015;8:57–63.

    Article  CAS  PubMed  Google Scholar 

  16. Hall W, Carter A. Is deep brain stimulation a prospective ‘cure’ for addiction? F1000 Med Rep. 2011;3:4.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Halpern CH, Torres N, Hurtig HI, Wolf JA, Stephen J, Oh MY, et al. Expanding applications of deep brain stimulation: a potential therapeutic role in obesity and addiction management. Acta Neurochirur. 2011;153:2293–306.

    Article  Google Scholar 

  18. Williams NR, Taylor JJ, Lamb K, Hanlon CA, Short EB, George MS. Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders. World J Radiol. 2014;28(6):756–78.

    Article  Google Scholar 

  19. Stephen JH, Halpern CH, Barrios CJ, Balmuri U, Pisapia JM, Wolf JA, et al. Deep brain stimulation compared with methadone maintenance for the treatment of heroin dependence: a treshold and cost-effectiveness analysis. Addiction. 2012;107:624–34.

    Article  PubMed  Google Scholar 

  20. Heinze HJ, Heldmann M, Voges J, Hinrichs H, Marco-Pallares J, Hopf JM, et al. Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects. Front Hum Neurosci. 2009;3:22.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Stelten BML, Noblesse LHM, Ackermans L, Temel Y, Visser-Vandewalle V. The neurosurgical treatment of addiction. Neurosurg Focus. 2008;25:E5.

    Article  PubMed  Google Scholar 

  22. Kuhn J, Bührle CP, Lenartz D, Sturm V. Deep brain stimulation in addiction due to psychoactive substance use. Handb Clin Neurol. 2013;116:259–69.

    Article  PubMed  Google Scholar 

  23. Vassoler FM, Schmidt HD, Gerard ME, Famous KR, Ciraulo DA, Kornetsky C, et al. Deep brain stimulation of the nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug seeking in rats. J Neurosci. 2008;28:8735–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Vassoler FM, White SL, Hopkins TJ, Guercio LA, Espallergues J, Berton O, et al. Deep brain stimulation of the nucleus accumbens shell attenuates cocaine reinstatement through local and antidromic activation. J Neurosci. 2013;33:14446–54.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Friedman A, Lax E, Dikshtein Y, Abraham L, Flaumenhaft Y, Sudai E, et al. Electrical stimulation of the lateral habenula produces enduring inhibitory effect on cocaine seeking behavior. Neuropharmacology. 2010;59:452–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Rouaud T, Lardeux S, Panayotis N, Paleressompoulle D, Cador M, Baunez C. Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation. Proc Natl Acad Sci. 2010;107:1196–200.

    Article  CAS  PubMed  Google Scholar 

  27. Baunez C, Dias C, Cador M, Amalric M. The subthalamic nucleus exerts opposite control on cocaine and ‘natural’ rewards. Nat Neurosci. 2005;8:484–9.

    CAS  PubMed  Google Scholar 

  28. Levy D, Shaba-Simon M, Shalev U, Barnea-Ygael N, Cooper A, Zangen A. Repeated electrical stimulation of reward-related brain regions affects cocaine but not natural reinforcement. J Neusosci. 2007;27:14179–89.

    CAS  Google Scholar 

  29. Wilden JA, Qing KY, Hauer SR, McBride WJ, Irazoqui P, Rodd ZA. Reduced ethanol consumption by alcohol-preferring (P) rats following pharmacological silencing and deep brain stimulation of the nucleus accumbens shell. J Neurosurg. 2014;120:997–1005.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Henderson MB, Green AI, Bradford PS, Chau DT, Roberts DW, Leiter JC. Deep brain stimulation of the nucleus accumbens reduces alcohol intake in alcohol-preferring rats. Neurosurg Focus. 2010;29:E12.

    Article  PubMed  Google Scholar 

  31. Knapp CM, Tozier L, Pak A, Ciraulo DA, Kornetsky C. Deep brain stimulation of the nucleus reduces ethanol consumption. Pharmacol Biochem Behav. 2009;92:474–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Kuhn J, Lenartz D, Huff W, Lee S, Koulousakis A, Klosterkoetter J, et al. Remission of alcohol dependency following deep brain stimulation of the nucleus accumbens: valuable therapeutic implications? J Neurol Neurosurg Psychiatry. 2007;78:1152–3.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Voges J, Müller U, Bogerts B, Münte T, Heinze HJ. Deep brain stimulation surgery for alcohol addiction. World Neurosurg. 2013;80(S28):e21–31.

    Google Scholar 

  34. Carter A, Hall W. Proposals to trial deep brain stimulation to treat addiction are premature. Addiction. 2011;106:235–7.

    Article  PubMed  Google Scholar 

  35. Kuhn J, Gründler TOJ, Bauer R, Huff W, Fischer AG, Lenartz D, et al. Succesful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoring. Addict Biol. 2011;16:620–3.

    Article  PubMed  Google Scholar 

  36. Guo L, Zhou H, Wang R, Xu J, Zhou W, Zhang F, et al. DBS of nucleus accumbens on heroin seeking behaviors in self-administering rats. Drug Alcohol Depend. 2013;129:70–81.

    Article  CAS  PubMed  Google Scholar 

  37. Liu HY, Jin J, Tang JS, Sun WX, Jia H, Yang XP, et al. Chronic deep brain stimulation in the rat nucleus accumbens and its effect on morphine reinforcement. Addict Biol. 2008;13:40–6.

    Article  PubMed  Google Scholar 

  38. Kuhn J, Möller M, Treppmann JF, Bartsch C, Lenartz D, Gruendler TOJ, et al. Deep brain stimulation of the nucleus accumbens and its usefulness in severe opioid addiction. Mol Psychiatry. 2014;19:145–6.

    Article  CAS  PubMed  Google Scholar 

  39. Zhou H, Xu J, Jiang J. Deep brain stimulation of nucleus accumbens on heroin-seeking behaviors: a case report. Biol Psychiatry. 2011;69:e41–2.

    Article  PubMed  Google Scholar 

  40. Valencia-Alfonso CE, Luigjes J, Smolders R, Cohen MX, Levar N, Mazaheri A, et al. Effective deep brain stimulation in heroin addiction: a case report with complementary intracranial electroencephalogram. Biol Psychiatry. 2012;71:e35–7.

    Article  PubMed  Google Scholar 

  41. Pushparaj A, Hamani C, Yu W, Shin DS, Kan B, Nobrega JN, et al. Electrical stimulation of the insular region attenuates nicotine-taking and nicotine seeking behaviors. Neuropsychopharmacology. 2013;38:690–8.

    Article  CAS  PubMed  Google Scholar 

  42. Naqvi NH, Rudrauf D, Damasio H, Bechara A. Damage to the insula disrupts addiction to cigarette smoking. Science. 2007;315:531–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Kuhn J, Bauer R, Pohl S, Lenartz D, Huff W, Kim EH, et al. Observations on unaided smoking cessation after deep brain stimulation of the nucleus accumbens. Eur Addict Res. 2009;15:196–201.

    Article  CAS  PubMed  Google Scholar 

  44. Mantione M, Brink W van den, Schuurman PR, Denys D. Smoking cessation and weight loss after chronic deep brain stimulation of the nucleus accumbens: therapeutic and research implications: case report. Neurosurgery. 2010;66:E218.

    Google Scholar 

  45. Benabid AL, Chabardes S, Mitrofanis J, Pollak P. Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson’s disease. Lancet Neurol. 2009;8:67–81.

    Article  PubMed  Google Scholar 

  46. McIntyre CC, Hahn PJ. Network perspectives on the mechanisms of deep brain stimulation. Neurobiol Dis. 2010;38:329–37.

    Article  PubMed  Google Scholar 

  47. Sturm V, Lenartz D, Koulousakis A, Treuer H, Herholz K, Klein JC, et al. The nucleus accumbens: a target for deep brain stimulation in obsessive-compulsive- and anxiety-disorders. J Chem Neuroanat. 2003;26:293–9.

    Article  PubMed  Google Scholar 

  48. Heldman M, Berding G, Voges J, Bogerts B, Galazky I, Müller U, et al. Deep brain stimulation of nucleus accumbens region in alocholism affects reward processing. PLoS One. 2012;7:e36572.

    Article  Google Scholar 

  49. Adinoff B, Rilling LM, Williams MJ, Schreffler E, Schepis TS, Rosvall T, et al. Impulsivity, neural deficits, and the addictions: the ‘oops’ factor in relapse. J Addict Dis. 2007;26(Suppl 1):25–39.

    Article  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Universitaire Dienst Psychiatrie, Universtair Ziekenhuis Gent, Gent, Belgium

    Sarah Herremans

  2. Universitaire Dienst Psychiatrie, Universitair Ziekenhuis Gent en Brussel, Gent, Belgium

    Chris Baeken

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  1. Sarah Herremans
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  2. Chris Baeken
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Editor information

Editors and Affiliations

  1. Maastricht University Medical Cente Department of Neurosurgery, Maastricht, The Netherlands

    Y. Temel

  2. Dept. Of Psychiatry, Maastricht Univeristy Medical Centre, Maastricht, The Netherlands

    A.F.G. Leentjens

  3. Afd. Neurologie, Amsterdam Medisch Centrum, Amsterdam, The Netherlands

    R.M.A. de Bie

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© 2016 Bohn Stafleu van Loghum

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Herremans, S., Baeken, C. (2016). Diepe hersenstimulatie bij verslaving. In: Temel, Y., Leentjens, A., de Bie, R. (eds) Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen. Bohn Stafleu van Loghum, Houten. https://doi.org/10.1007/978-90-368-0959-7_19

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  • DOI: https://doi.org/10.1007/978-90-368-0959-7_19

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  • Publisher Name: Bohn Stafleu van Loghum, Houten

  • Print ISBN: 978-90-368-0958-0

  • Online ISBN: 978-90-368-0959-7

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