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Diepe hersenstimulatie bij medicatieresistente depressies

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Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen

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Vanwege toegenomen inzichten in de pathofysiologie en de gerapporteerde effecten van diepe hersenstimulatie (‘deep brain stimulation’, DBS) op stemmingsklachten bij aandoeningen als de ziekte van Parkinson en de obsessieve-compulsieve stoornis, wordt DBS ook onderzocht als behandelmogelijkheid voor patiënten met een depressieve stoornis. Het gaat daarbij om therapieresistente depressieve patiënten die niet hersteld zijn met eerdere psychotherapeutische en farmacologische behandelingen. In tegenstelling tot eerder gepubliceerd open onderzoek, liet een gerandomiseerde klinische trial geen therapeutisch effect zien van stimulatie van de ventrale capsula interna/ventraal striatum (VC/VS). Ook eerder werden twee gerandomiseerde onderzoeken, één met betrekking tot stimulatie van de VC/VS en één met betrekking tot stimulatie van de subgenuale gyrus cinguli, voortijdig afgebroken vanwege gebrek aan effectiviteit. Hoewel de depressieve stoornis als potentiële behandelindicatie voor DBS aantrekkelijk blijft, past deze behandeling vooralsnog niet in een regulier behandelaanbod, en dient zij alleen aangeboden te worden als experimentele behandeling of in het kader van wetenschappelijk onderzoek.

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Author information

Authors and Affiliations

  1. Afdeling Psychiatrie, Maastricht UMC+, Maastricht, The Netherlands

    Albert Leentjens

  2. Afdeling Neurochirurgie, Maastricht UMC+, Maastricht, The Netherlands

    Yasin Temel

Authors
  1. Albert Leentjens
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  2. Yasin Temel
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Editor information

Editors and Affiliations

  1. Maastricht University Medical Cente Department of Neurosurgery, Maastricht, The Netherlands

    Y. Temel

  2. Dept. Of Psychiatry, Maastricht Univeristy Medical Centre, Maastricht, The Netherlands

    A.F.G. Leentjens

  3. Afd. Neurologie, Amsterdam Medisch Centrum, Amsterdam, The Netherlands

    R.M.A. de Bie

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© 2016 Bohn Stafleu van Loghum

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Leentjens, A., Temel, Y. (2016). Diepe hersenstimulatie bij medicatieresistente depressies. In: Temel, Y., Leentjens, A., de Bie, R. (eds) Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen. Bohn Stafleu van Loghum, Houten. https://doi.org/10.1007/978-90-368-0959-7_18

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  • DOI: https://doi.org/10.1007/978-90-368-0959-7_18

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  • Publisher Name: Bohn Stafleu van Loghum, Houten

  • Print ISBN: 978-90-368-0958-0

  • Online ISBN: 978-90-368-0959-7

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