Skip to main content
SpringerLink
Log in

Diepe hersenstimulatie bij tremoraandoeningen

  • Chapter
  • First Online:
Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen

  • 617 Accesses

Samenvatting

In de afgelopen dertig jaar is diepe hersenstimulatie (‘deep brain stimulation’, DBS) een waardevolle en veilige behandeling gebleken voor patiënten met tremor bij wie medicamenteuze therapie onvoldoende effectief was. In de jaren tachtig en negentig van de vorige eeuw werd DBS van de nucleus ventralis intermedius (VIM) van de thalamus veelvuldig toegepast bij essentiële tremor (ET), de ziekte van Parkinson (ZvP) en multipele sclerose (MS). Aangezien bij ZvP-patiënten VIM DBS is vervangen voor DBS van de nucleus subthalamicus, en de effecten van VIM DBS bij MS-patiënten tegenvielen, wordt VIM DBS tegenwoordig met name toegepast bij ET en enkele zeldzamere vormen van tremor, zoals orthostatische tremor en holmes(rubrale)tremor. Het tremoronderdrukkend effect van VIM DBS bij ET-patiënten is de eerste jaren vaak zeer goed, maar na twee tot vijf jaar treedt dikwijls zogeheten DBS-tolerantie op, waardoor de tremor terugkeert. Het verder ophogen van de DBS is, vanwege bijwerkingen zoals paresthesieën, spiercontracties of dysartrie, niet altijd mogelijk. In recentere jaren is daarom uitgeweken naar andere regio’s zoals de ‘posterior subthalamic area’ (PSA). Toekomstig onderzoek zal uitwijzen wat de toegevoegde waarde van deze alternatieven is.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 99.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatuur

  1. Louis ED, Ferreira JJ. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord. 2010;25:534–41.

    Article  PubMed  Google Scholar 

  2. Baumann CR. Epidemiology, diagnosis and differential diagnosis in Parkinson’s disease tremor. Parkinsonism Relat Disord. 2012;18(Suppl 1):S90–2.

    Article  PubMed  Google Scholar 

  3. Koch M, Mostert J, Heersema D, Keyser J de. Tremor in multiple sclerosis. J Neurol. 2007;254:133–45.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Fasano A, Bove F, Lang AE. The treatment of dystonic tremor: a systematic review. J Neurol Neurosurg Psychiatry. 2014;85:759–69.

    Article  PubMed  Google Scholar 

  5. Zeuner KE, Deuschl G. An update on tremors. Curr Opin Neurol. 2012;25:475–82.

    Article  PubMed  Google Scholar 

  6. Deuschl G, Raethjen J, Hellriegel H, Elbe R. Treatment of patients with essential tremor. Lancet Neurol. 2011;10:148–61.

    Article  PubMed  Google Scholar 

  7. Pogarell O, Gasser T, Hilten JJ van, Spieker S, Pollentier S, Meier D, Oertel WH. Pramipexole in patients with Parkinson’s disease and marked drug resistent tremor: a randomised, double-blind placebo controlled multicentre study. J Neurol Neurosurg Psychiatry. 2002;72:713–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Koch M, Mostert J, Heersema D, Keyser J de. Tremor in multiple sclerosis. J Neurol. 2007;254:133–45.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Sharifi S, Nederveen AJ, Booij J, Rootselaar AF van. Neuroimaging essentials in essential tremor: a systematic review. Neuroimage Clin. 2014;5:217–31.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Wills AJ, Jenkins IH, Thompson PD, Findley LJ, Brooks DJ. Red nuclear and cerebellar but no olivary activation associated with essential tremor: a positron emission tomographic study. Ann Neurol. 1994;36:636–42.

    Article  CAS  PubMed  Google Scholar 

  11. Hua SE, Lenz FA. Posture-related oscillations in human cerebellar thalamus in essential tremor are enabled by voluntary motor circuits. J Neurophysiol. 2005;93:117–27.

    Article  PubMed  Google Scholar 

  12. Timmermann L, Gross J, Dirks M, Volkmann J, Freund HJ, Schnitzler A. The cerebral oscillatory network of parkinsonian resting tremor. Brain. 2003;126:199–212.

    Article  PubMed  Google Scholar 

  13. Helmich RC, Janssen MJ, Oyen WJ, Bloem BR, Toni I. Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor. Ann Neurol. 2011;69:269–81.

    Article  PubMed  Google Scholar 

  14. Contarino MF, Bour LJ, Bot M, Munckhof P van den, Speelman JD, Schuurman PR, Bie RM de. Tremor-specific neuronal oscillation pattern in dorsal subthalamic nucleus of parkinsonian patients. Brain Stimul. 2012;5:305–14.

    Article  PubMed  Google Scholar 

  15. Kocabicak E, Terzi M, Alptekin O, Temel Y. Targeting thalamic tremor cells in deep brain stimulation for multiple sclerosis-induced complex tremor. Surg Neurol Int. 2013;22(4):31.

    Article  Google Scholar 

  16. Hassler R, Riechert T. Indikationen und Lokalisationsmethode der gezielten Hirnoperationen. Nervenartz. 1954;25:441–7.

    CAS  Google Scholar 

  17. Brice J, McLellan L. Suppression of intention tremor by contingent deep-brain stimulation. Lancet. 1980;1:1221–2.

    Article  CAS  PubMed  Google Scholar 

  18. Benabid AL, Pollak P, Seigneuret E, Hoffmann D, Gay E, Perret J. Chronic VIM thalamic stimulation in Parkinson’s disease, essential tremor and extra-pyramidal dyskinesias. Acta Neurochir Suppl. (Wien). 1993;58:39–44.

    CAS  Google Scholar 

  19. Schuurman PR, Bosch DA, Bossuyt PMM, Bonsel GJ, Someren EJW van, Bie RMA de, Merkus MP, Speelman JD. A comparison of continuous thalamic stimulation and thalamotoy for suppression of severe tremor. N Engl J Med. 2000;342:461–8.

    Article  CAS  PubMed  Google Scholar 

  20. Schaltenbrand G, Wahren W. Atlas for stereotaxy of the human brain. Stuttgart: George Thieme. 1977.

    Google Scholar 

  21. Garonzik IM, Hua SE, Ohara S, Lenz FA. Intraoperative microelectrode and semi-microelectrode recording during the physiological localization of the thalamic nucleus ventral intermediate. Mov Disord. 2002;17(Suppl 3):S135–44.

    Article  PubMed  Google Scholar 

  22. Schuurman PR, Bosch DA, Merkus MP, Speelman JD. Long-term follow-up of thalamic stimulation versus thalamotomy for tremor suppression. Mov Dis. 2008;23:1146–53.

    Article  Google Scholar 

  23. Pahwa R, Lyons KE, Wilkinson SM, Simpson RK Jr, Ondo WG, Tarsy D, et al. Long-term evaluation of deep brain stimulation of the thalamus. J Neurosurg. 2006;104:506–12.

    Article  PubMed  Google Scholar 

  24. Hariz MI, Krack P, Alesch F, Augustinsson LE, Bosch A, Ekberg R, et al. Multicentre European study of thalamic stimulation for parkinsonian tremor: a 6 year follow-up. J Neurol Neurosurg Psychiatry. 2008;79:694–9.

    Article  CAS  PubMed  Google Scholar 

  25. Koller WC, Lyons KE, Wilkinson SB, Troster AI, Pahwa R. Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor. Mov Disord. 2001;16:464–8.

    Article  CAS  PubMed  Google Scholar 

  26. Sydow O, Thobois S, Alesch F, Speelman JD. Multicentre European study of thalamic stimulation in essential tremor: a six year follow-up. J Neurol Neurosurg Psychiatry. 2003;74:1387–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Blomstedt P, Hariz GM, Hariz MI, Koskinen LO. Thalamic deep brain stimulation in the treatment of essential tremor: a long-term follow-up. Br J Neurosurg. 2007;21:504–9.

    Article  CAS  PubMed  Google Scholar 

  28. Berk C, Carr J, Sinden M, Martzke J, Honey CR. Thalamic deep brain stimulation for the treatment of tremor due to multiple sclerosis: a prospective study of tremor and quality of life. J Neurosurg. 2002;97:815–20.

    Article  PubMed  Google Scholar 

  29. Torres CV, Moro E, Lopes-Rios AL, Hodaie M, Chen R, Laxton AW, et al. Deep brain stimulation of the ventral intermediate nucleus of the thalamus for tremor in patients with multiple sclerosis. Neurosurgery. 2010;67:646–51.

    Article  PubMed  Google Scholar 

  30. Putzke JD, Uitti RJ, Obwegeser AA, Wszolek ZK, Wharen RE. Bilateral thalamic deep brain stimulation: midline tremor control. J Neurol Neurosurg Psychiatry. 2005;76:684–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Shih LC, LaFaver K, Lim C, Papavassiliou E, Tarsy D. Loss of benefit in VIM thalamic deep brain stimulation (DBS) for essential tremor (ET): how prevalent is it? Parkinsonism Relat Disord. 2013;19:676–9.

    Article  PubMed  Google Scholar 

  32. Minguez-Castellanos A, Carnero-Pardo C, Gómez-Camello A, Ortega-Moreno A, García-Gómez T, Arjona V, et al. Primary writing tremor treated by chronic thalamic stimulation. Mov Disord. 1999;14:1030–3.

    Article  CAS  PubMed  Google Scholar 

  33. Guridi J, Rodriguez-Oroz MC, Arbizu J, Alegre M, Prieto E, Landecho I, et al. Successful thalamic deep brain stimulation for orthostatic tremor. Mov Disord. 2008;23:1808–11.

    Article  PubMed  Google Scholar 

  34. Nikkhah G, Prokop T, Hellwig B, Lücking CH, Ostertag CB. Deep brain stimulation of the nucleus ventralis intermedius for Holmes (rubral) tremor and associated dystonia caused by upper brain lesions. Report of two cases. J Neurosurg. 2004;100:1079–83.

    PubMed  Google Scholar 

  35. Limousin P, Krack P, Pollak P, Benazzouz A, Ardouin C, Hoffmann D, et al. Electrical stimulation of the subthalamic nucleus in advanced Parkinson’s disease. New Engl J Med. 1998;339:1105–11.

    Article  CAS  PubMed  Google Scholar 

  36. Diamond A, Shahed J, Jankovic J. The effects of subthalamic nucleus deep brain stimulation on parkinsonian tremor. J Neurol Sci. 2007;260:199–203.

    Article  PubMed  Google Scholar 

  37. Bittar RG, Hyma J, Nandi D, Wang S, Liu X, Joint C, et al. Thalamotomy versus thalamic stimulation for multiple sclerosis tremor. J Clin Neurosci. 2005;12:638–42.

    Article  PubMed  Google Scholar 

  38. Munckhof P van den, Contarino MF, Bour LJ, Speelman JD, Bie RM de, Schuurman PR. Postoperative curving and upward displacement of deep brain stimulation electrodes caused by brain shift. Neurosurgery. 2010;67:49–53.

    Article  PubMed  Google Scholar 

  39. Contarino MF, Bot M, Speelman JD, Bie RM de, Tijssen MA, Denys D, et al. Postoperative displacement of deep brain electrodes related to lead-anchoring technique. Neurosurger. 2013;73:681–8.

    Article  Google Scholar 

  40. Kitagawa M, Murata J, Kikuchi S, Sawamura Y, Saito H, Sasaki H, et al. Deep brain stimulation of subthalamic area for severe proximal tremor. Neurology. 2000;55:114–6.

    Article  CAS  PubMed  Google Scholar 

  41. Blomstedt P, Fytagoridis A, Tosch S. Deep brain stimulation of the posterior subthalamic area in the treatment of tremor. Acta Neurochir. (Wien). 2009;151:31–6.

    Article  CAS  Google Scholar 

  42. Contarino MF, Speelman JD, Bie RM de, Schuurman PR, Munckhof P van den. Bilateral cerebellorubrothalamic fibers stimulation for essential tremor? Mov Disord. 2011;26:1366–7.

    Article  PubMed  Google Scholar 

  43. Murata J, Kitagawa M, Uesugi H, Saito H, Iwasaki Y, Kikuchi S, et al. Electrical stimulation of the posterior subthalamic area for the treatment of intractable proximal tremor. J Neurosurg. 2003;99:708–15.

    Article  PubMed  Google Scholar 

  44. Plaha P, Javed S, Agombar D, O’Farrell G, Khan S, Whone A, et al. Bilateral caudal zona incerta nucleus stimulation for essential tremor: outcome and quality of life. J Neurol Neurosurg Psychiatry. 2011;82:899–904.

    Article  PubMed  Google Scholar 

  45. Fytagoridis A, Sandvik U, Aström M, Bergenheim T, Blomstedt P. Long term follow-up of deep brain stimulation of the caudal zona incerta for essential tremor. J Neurol Neurosurg Psychiatry. 2012;83:258–62.

    Article  PubMed  Google Scholar 

  46. Hamel W, Herzog J, Kopper F, Pinsker M, Weinert D, Müller D, et al. Deep brain stimulation in the subthalamic area is more effective than nucleus ventralis intermedius stimulation for bilateral intention tremor. Acta Neurochir. (Wien). 2007;149:749–58.

    Article  CAS  Google Scholar 

  47. Blomstedt P, Lindvall P, Linder J, Olivecrona M, Forsgen L, Hariz MI. Reoperation after failed deep brain stimulation for essential tremor. World Neurosurg. 2012;78:554.e1–554.e5.

    Google Scholar 

  48. Kondziolka D, Whting D, Germanwala A, Oh M. Hardware-related complications after placement of thalamic deep brain stimulator systems. Stereotact Funct Neurosurg. 2002;79:228–33.

    Article  PubMed  Google Scholar 

  49. Koller W, Pahwa R, Busenbark K, Hubble J, Wilkinson S, Lang A, et al. High frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor. Ann Neurol. 1997;42:292–9.

    Article  CAS  PubMed  Google Scholar 

  50. Limousin P, Speelman J, Gielen F, Janssens M. Multicentre European study of thalamic stimulation in parkinsonian and essential tremor. J Neurol Neurosurg Psychiatry. 1999;66:289–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Sitburana O, Almaguer M, Ondo WG. A pilot study: microlesion effects and tremor outcome in the ventrointermediate deep brain stimulation (VIM-DBS). Clin Neurol Neurosurg. 2010;112:106–9.

    Article  PubMed  Google Scholar 

  52. Falowski S, Ooi YC, Smith A. Verhagen Metman L, Bakay RA. An evaluation of hardware and surgical complications with deep brain stimulation based on diagnosis and lead location. Stereotact Funct Neurosurg. 2012;90:173–80.

    Article  PubMed  Google Scholar 

  53. Laurent V, Munckhof P van den, Contarino MF, Veer O van der, Velseboer DC, Scholten MN, et al. Patient perception of deep brain stimulation hardware. Mov Disord. 2013;28:1754–5.

    Article  PubMed  Google Scholar 

  54. Baizabal-Carvallo JF, Kagnoff MN, Jimenez-Shahed J, Fekete R, Jankovic J. The safety and efficacy of thalamic deep brain stimulation in essential tremor. 10 years and beyond. J Neurol Neurosurg Psychiatry. 2014;85:567–72.

    Article  PubMed  Google Scholar 

  55. Hwynn N, Hass CJ, Zeilman P, Romrell J, Dai Y, Wu SS, et al. Steady or not following thalamic deep brain stimulation for essential tremor. J Neurol. 2011;258:1643–8.

    Article  PubMed  Google Scholar 

  56. Favilla CG, Ullman D, Wagle Shukla A, Foote KD, Jacobsen CE 4th, Okun MS. Worsening essential tremor following deep brain stimulation: disease progression versus tolerance. Brain. 2012;135:1455–62.

    Article  PubMed  Google Scholar 

  57. Fytagoridis A, Aström M, Wardell K, Blomstedt P. Stimulation-induced side effects in the posterior subthalamic area: distribution, characteristics and visualization. Clin Neurol Neurosurg. 2013;115:65–71.

    Article  CAS  PubMed  Google Scholar 

  58. Kwon HG, Hong JH, Hong CP, Les DH, Ahn SH, Jang SH. Dentatorubrothalamic tract in human brain: diffusion tensor tractography study. Neuroradiology. 2011;53:787–91.

    Article  PubMed  Google Scholar 

  59. Coenen VA, Allert N, Mädler B. A role of diffusion tensor imaging fiber tracking in deep brain stimulation surgery: DBS of the dentato-rubro-thalamic tract (drt) for the treatment of therapy-refractory tremor. Acta Neurochir. 2011;153:1579–85.

    Article  PubMed  Google Scholar 

  60. Coenen VA, Allert N, Paus S, Kronenbürger M, Urbach H, Mädler B. Modulation of the cerebello-thalamo-cortical network in thalamic deep brain stimulation for tremor: a diffusion tensor imaging study. Neurosurgery. 2014;75:657–69.

    Article  PubMed  Google Scholar 

  61. Schlaier J, Anthofer J, Steib K, Fellner C, Rothenfusser E, Brawanski A, Lange M. Deep brain stimulation for essential tremor: targeting the dentate-rubro-thalamic tract? Neuromodulation 2014 [Epub ahead of print].

    Google Scholar 

  62. Katayama Y, Kano T, Kobayashi K, Oshima H, Fukaya C, Yamamoto T. Difference in surgical strategies between thalamotomy and thalamic deep brain stimulation for tremor control. J Neurol. 2005;252(Suppl 4):IV17–IV22.

    Google Scholar 

  63. Yu H, Hedera P, Fang J, Davis TL, Konrad PE. Confined stimulation using dual thalamic deep brain stimulation leads rescues refractory essential tremor: report of three cases. Stereotact Funct Neurosurg. 2009;87:309–13.

    Article  PubMed  Google Scholar 

  64. Lind G, Schechtmann G, Lind C, Winter J, Meyerson BA, Linderoth B. Subthalamic stimulation for essential tremor. Stereotact Funct Neurosurg. 2008;86:253–8.

    Article  PubMed  Google Scholar 

  65. Young RF, Li F, Vermeulen S, Meier R. Gamma knife thalamotomy for treatment of essential tremor: long-term results. J Neurosurg. 2010;112:1311–7.

    Article  PubMed  Google Scholar 

  66. Kooshkabadi A, Lunsford LD, Tonetti D, Flickinger JC, Kondziolka D. Gamma knife thalamotomy for tremor in the magnetic resonance imaging era. J Neurosurg. 2013;118:713–8.

    Article  PubMed  Google Scholar 

  67. Lipsman N, Schwartz ML, Huang Y, Lee L, Sankar T, Chapman M, et al. MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study. Lancet Neurol. 2013;12:462–8.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Afdeling Neurochirurgie, Academisch Medisch Centrum, Amsterdam, The Netherlands

    Pepijn van den Munckhof

  2. Afdeling Neurologie, HagaZiekenhuis, Den Haag, The Netherlands

    Fiorella Contarino

  3. Afdeling Neurologie en Klinische neurofysiologie, Academisch Medisch Centrum, Amsterdam, The Netherlands

    Fleur van Rootselaar

Authors
  1. Pepijn van den Munckhof
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fiorella Contarino
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fleur van Rootselaar
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Maastricht University Medical Cente Department of Neurosurgery, Maastricht, The Netherlands

    Y. Temel

  2. Dept. Of Psychiatry, Maastricht Univeristy Medical Centre, Maastricht, The Netherlands

    A.F.G. Leentjens

  3. Afd. Neurologie, Amsterdam Medisch Centrum, Amsterdam, The Netherlands

    R.M.A. de Bie

Copyright information

© 2016 Bohn Stafleu van Loghum

About this chapter

Cite this chapter

van den Munckhof, P., Contarino, F., van Rootselaar, F. (2016). Diepe hersenstimulatie bij tremoraandoeningen. In: Temel, Y., Leentjens, A., de Bie, R. (eds) Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen. Bohn Stafleu van Loghum, Houten. https://doi.org/10.1007/978-90-368-0959-7_12

Download citation

  • DOI: https://doi.org/10.1007/978-90-368-0959-7_12

  • Published:

  • Publisher Name: Bohn Stafleu van Loghum, Houten

  • Print ISBN: 978-90-368-0958-0

  • Online ISBN: 978-90-368-0959-7

  • eBook Packages: Dutch language eBook collection

Publish with us

Policies and ethics

Search

Navigation