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Diepe hersenstimulatie bij de ziekte van Parkinson

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Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen

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Diepe hersenstimulatie (‘deep brain stimulation’, DBS) voor de ziekte van Parkinson kan worden overwogen bij patiënten met responsfluctuaties, als aanpassingen in het medicatieschema onvoldoende helpen. DBS verbetert vooral de motorische symptomen, zoals tremor, bradykinesie en rigiditeit. Daarnaast is de tijd die patiënten in de off-fase doorbrengen na DBS korter. Verder kan de medicatie vaak worden verminderd en nemen de dyskinesieën af. De belangrijkste risico’s van DBS zijn een (zelden voorkomend) intracerebraal hematoom, infectie, apparatuurgerelateerde complicaties en cognitieve en/of gedragsstoornissen. Er zijn verschillende doelgebieden voor diepe hersenstimulatie onderzocht. De nucleus subthalamicus (‘subthalamic nucleus’, STN) lijkt de meest effectieve keuze. Recent onderzoek heeft aangetoond, dat ook in een vroegere fase van de ziekte, als responsfluctuaties beginnen op te treden, DBS beter werkt dan alleen medicatie voor het verminderen van de motorische symptomen en verbeteren van de kwaliteit van leven. Hierdoor neemt het aantal patiënten dat in aanmerking komt voor DBS toe.

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Literatuur

  1. Schrag A, Quinn N. Dyskinesias and motor fluctuations in Parkinson’s disease. A community-based study. Brain. 2000;123:2297–305.

    PubMed  Google Scholar 

  2. Vidailhet M. Movement disorders in 2010: Parkinson disease-symptoms and treatments. Nat Rev Neurol. 2011;7:70–2.

    Article  CAS  PubMed  Google Scholar 

  3. Limousin P, Krack P, Pollak P, et al. Electrical stimulation of the subthalamic nucleus in advanced Parkinson’s disease. New Engl J Med. 1998;339:1105–11.

    Article  CAS  PubMed  Google Scholar 

  4. Schuepbach WM, Rau J, Knudsen K, et al. Neurostimulation for Parkinson’s disease with early motor complications. New Engl J Med. 2013;368:610–22.

    Article  CAS  PubMed  Google Scholar 

  5. Okun MS, Tagliati M, Pourfar M, et al. Management of referred deep brain stimulation failures; a retrospective analysis from 2 movement disorders centers. Arch Neurol. 2005;62:1250–5.

    Article  PubMed  Google Scholar 

  6. Deuschl G, Schade-Brittinger C, Krack P, et al. A randomized trial of deep-brain stimulation for Parkinson’s disease. New Engl J Med. 2006;355:896–908.

    Article  CAS  PubMed  Google Scholar 

  7. Weaver FM, Follett K, Stern M, et al. Bilateral deep brain stimulation vs. best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial. J Am Med Assoc. 2009;301:63–73.

    Article  CAS  Google Scholar 

  8. Follett KA, Weaver FM, Stern M, et al. Pallidal versus subthalamic deep-brain stimulation for Parkinson’s disease. New Engl J Med. 2010;362:2077–91.

    Article  CAS  PubMed  Google Scholar 

  9. Williams A, Gill S, Varma T, et al. Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson’s disease (PD SURG trial): a randomised, open-label trial. Lancet Neurol. 2010;9:581–91.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Odekerken VJ, Laar T van, Staal MJ, et al. Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson’s disease (NSTAPS study): a randomised controlled trial. Lancet Neurol. 2013;12:37–44.

    Article  PubMed  Google Scholar 

  11. Kleiner-Fisman G, Fisman DN, Sime E, Saint-Cyr JA, Lozano AM, Lang AE. Long-term follow up of bilateral deep brain stimulation of the subthalamic nucleus in patients with advanced Parkinson disease. J Neurosurg. 2003;99:489–95.

    Article  PubMed  Google Scholar 

  12. Kim HJ, Jeon BS, Paek SH, et al. Bilateral subthalamic deep brain stimulation in Parkinson disease patients with severe tremor. Neurosurgery. 2010;67:626–32.

    Article  PubMed  Google Scholar 

  13. Schuurman PR, Bosch DA, Bossuyt PM, et al. A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor. New Engl J Med. 2000;342:461–8.

    Article  CAS  PubMed  Google Scholar 

  14. Esselink RA, Bie RM de, Haan RJ de, et al. Unilateral pallidotomy versus bilateral subthalamic nucleus stimulation in PD: a randomized trial. Neurology. 2004;62:201–7.

    Article  CAS  PubMed  Google Scholar 

  15. Voon V, Fox SH. Medication-related impulse control and repetitive behaviors in Parkinson disease. Arch Neurol. 2007;64:1089–96.

    Article  PubMed  Google Scholar 

  16. Gee L, Smith H, La Cruz P De, et al. The influence of bilateral subthalamic nucleus deep brain stimulation on impulsivity and prepulse inhibition in Parkinson’s disease patients. Stereotact Funct Neurosurg. 2015;93:265–70.

    Google Scholar 

  17. Jahanshahi M, Obeso J, Baunez C, Alegre M, Krack P. Parkinson’s disease, the subthalamic nucleus, inhibition and impulsivity. Mov Disord. 2015;30:128–40.

    Article  PubMed  Google Scholar 

  18. Okun MS, Weintraub D. Should impulse control disorders and dopamine dysregulation syndrome be indications for deep brain stimulation and intestinal levodopa? Mov Disord. 2013;28(14):1915–9.

    Article  CAS  PubMed  Google Scholar 

  19. Smeding HM, Speelman JD, Huizenga HM, Schuurman PR, Schmand B. Predictors of cognitive and psychosocial outcome after STN DBS in Parkinson’s Disease. J Neurol Neurosurg Psychiatry. 2011;82:754–60.

    Article  PubMed  Google Scholar 

  20. Vercruysse S, Vandenberghe W, Münks L, Nuttin B, Devos H, Nieuwboer A. Effects of deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson’s disease: a prospective controlled study. J Neurol Neurosurg Psychiatry. 2014;85:871–7.

    Article  CAS  PubMed  Google Scholar 

  21. Velseboer DC, Broeders M, Post B, et al. Prognostic factors of motor impairment, disability, and quality of life in newly diagnosed PD. Neurology. 2013;80(7):627–33.

    Article  PubMed  Google Scholar 

  22. Okun MS, Gallo BV, Mandybur G, et al. Subthalamic deep brain stimulation with a constant-current device in Parkinson’s disease: an open-label randomised controlled trial. Lancet Neurol. 2012;11:140–9.

    Article  PubMed  Google Scholar 

  23. Weaver FM, Follett KA, Stern M, et al. Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes. Neurology. 2012;79:55–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Anderson VC, Burchiel KJ, Hogarth P, Favre J, Hammerstad JP. Pallidal vs subthalamic nucleus deep brain stimulation in Parkinson disease. Arch Neurol. 2005;62:554–60.

    Article  PubMed  Google Scholar 

  25. Kleiner-Fisman G, Herzog J, Fisman DN, et al. Subthalamic nucleus deep brain stimulation: summary and meta-analysis of outcomes. Mov Disord. 2006;21(Suppl 14):S290–304.

    Article  PubMed  Google Scholar 

  26. Okun M. Deep-brain stimulation for Parkinson’s Disease. New Engl J Med. 2012;367:1529–38.

    Article  CAS  PubMed  Google Scholar 

  27. Appleby B, Duggan P, Regenberg A, et al. Psychiatric and neuropsychiatric adverse events associated with deep brain stimulation: a meta-analysis of ten years’ experience. Mov Disord. 2007;22:1722–8.

    Article  PubMed  Google Scholar 

  28. Castrioto A, Lhommée E, Moro E, Krack P. Mood and behavioural effects of subthalamic stimulation in Parkinson’s disease. Lancet Neurol. 2014;13(3):287–305.

    Article  PubMed  Google Scholar 

  29. Thobois S, Ardouin C, Lhommée E, et al. Non-motor dopamine withdrawal syndrome after surgery for Parkinson’s disease: predictors and underlying mesolimbic denervation. Brain. 2010;133:1111–27.

    Article  PubMed  Google Scholar 

  30. Rothlind JC, York MK, Carlson K, et al. Neuropsychological changes following deep brain stimulation surgery for Parkinson’s disease: comparisons of treatment at pallidal and subthalamic targets versus best medical therapy. J Neurol Neurosurg Psychiatry. 2015;86:622–9.

    Article  PubMed  Google Scholar 

  31. Odekerken VJJ, Boel JA, Geurtsen GJ, et al. Neuropsychological outcome after deep brain stimulation for Parkinson’s disease. Neurology. 2015;84:1355–61.

    Article  CAS  PubMed  Google Scholar 

  32. Witt K, Daniels C, Reiff J. Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson’s disease: a randomised, multicentre study. Lancet Neurol. 2008;7:605–14.

    Article  PubMed  Google Scholar 

  33. Voon V, Krack P, Lang AE, et al. A multicenter study on suicide outcomes following subthalamic stimulation for Parkinson’s disease. Brain. 2008;131:2720–8.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Laurent V, Munckhof P van den, Contarino MF, et al. Patient perception of deep brain stimulation hardware. Mov Disord. 2013;28:1754–5.

    Article  PubMed  Google Scholar 

  35. Krack P, Batir A, Blercom N van, et al. Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. New Engl J Med. 2003;349:1925–34.

    Article  CAS  PubMed  Google Scholar 

  36. Aviles-Olmos I, Kefalopoulou Z, Tripoliti E, et al. Long-term outcome of subthalamic nucleus deep brain stimulation for Parkinson’s disease using an MRI-guided and MRI-verified approach. J Neurol Neurosurg Psychiatry. 2014;85:1419–25.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Strauss I, Kalia S, Lozano A. Where are we with surgical therapies for Parkinson’s disease? Parkinsonism Relat Disord. 2014;20(Suppl 1):S187–91.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Afdeling Neurologie, Universitair Medisch Centrum Groningen, Groningen, The Netherlands

    Teus van Laar

  2. Afdeling Neurologie, Academisch Medisch Centrum/Universiteit van Amsterdam, Amsterdam, The Netherlands

    Vincent Odekerken

  3. Afdeling Neurologie, Academisch Medisch Centrum, Amsterdam, The Netherlands

    Rob de Bie

Authors
  1. Teus van Laar
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  2. Vincent Odekerken
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  3. Rob de Bie
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Editor information

Editors and Affiliations

  1. Maastricht University Medical Cente Department of Neurosurgery, Maastricht, The Netherlands

    Y. Temel

  2. Dept. Of Psychiatry, Maastricht Univeristy Medical Centre, Maastricht, The Netherlands

    A.F.G. Leentjens

  3. Afd. Neurologie, Amsterdam Medisch Centrum, Amsterdam, The Netherlands

    R.M.A. de Bie

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© 2016 Bohn Stafleu van Loghum

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van Laar, T., Odekerken, V., de Bie, R. (2016). Diepe hersenstimulatie bij de ziekte van Parkinson. In: Temel, Y., Leentjens, A., de Bie, R. (eds) Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen. Bohn Stafleu van Loghum, Houten. https://doi.org/10.1007/978-90-368-0959-7_10

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  • DOI: https://doi.org/10.1007/978-90-368-0959-7_10

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  • Publisher Name: Bohn Stafleu van Loghum, Houten

  • Print ISBN: 978-90-368-0958-0

  • Online ISBN: 978-90-368-0959-7

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