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Diepe hersenstimulatie (‘deep brain stimulation’, DBS) is een behandeling waarbij door middel van chronische elektrische stroompulsen in bepaalde hersengebieden therapeutische effecten kunnen worden bereikt. Deze behandelmethode heeft zich vooral kunnen ontwikkelen door de introductie van het stereotaxieapparaat in 1947 en de publicatie van betrouwbare stereotaxieatlassen. Hierdoor werd het mogelijk in bepaalde hersenstructuren gericht laesies aan te brengen. Later werd het aanbrengen van laesies vervangen door permanente hoogfrequente stimulatie van specifieke hersenstructuren. Stimulatie werd sinds de jaren vijftig van de vorige eeuw toegepast bij psychiatrische indicaties, maar verloor door ethische bezwaren en de introductie van neuroleptica weer snel aan terrein. In de jaren zestig van de vorige eeuw werden de eerste behandelingen bij bewegingsstoornissen uitgevoerd. DBS verkreeg in 1997 erkenning voor de behandeling van tremoren, later gevolgd voor de indicaties ziekte van Parkinson, dystonieën, obsessieve-compulsieve stoornis en epilepsie.

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Speelman, H. (2016). DBS in historisch perspectief. In: Temel, Y., Leentjens, A., de Bie, R. (eds) Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen. Bohn Stafleu van Loghum, Houten. https://doi.org/10.1007/978-90-368-0959-7_1

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