Skip to main content

Part of the book series: Imaging & Formazione ((IMAG))

  • 519 Accesses

Riassunto

Negli ultimi anni il rapido sviluppo delle biotecnologie ha permesso di acquisire importanti conoscenze sulle basi molecolari che regolano il funzionamento normale o patologico di organismi di diversa complessità. Dal punto di vista della medicina, ciò ha rappresentato la base per l’identificazione di approcci terapeutici innovativi fondati sul concetto di medicina molecolare e di terapia personalizzata. A loro volta, medicina molecolare e terapia personalizzata hanno determinato un notevole input e ampia diffusione delle metodiche di imaging biomedico sia in campo clinico sia, soprattutto negli ultimi anni, nel settore preclinico.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 29.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 39.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

Bibliografia

  1. Pysz MA, Gambhir SS, Willmann JK (2010) Molecular imaging: current status and emerging strategies. Clin Radiol 65(7):500–516

    Article  PubMed  CAS  Google Scholar 

  2. Pien HH, Fischman AJ, Thrall JH, Sorensen AG (2005) Using imaging biomarkers to accelerate drug development and clinical trials. Drug Discov Today 10:259–266

    Article  PubMed  CAS  Google Scholar 

  3. Srinivas M, Aarntzen EH, Bulte JW et al (2010) Imaging of cellular therapies. Adv Drug Deliv Rev 62(11):1080–1093

    Article  PubMed  CAS  Google Scholar 

  4. Hahn MA, Singh AK, Sharma P et al (2011) Nanoparticles as contrast agents for in-vivo bioimaging: current status and future perspectives. Anal Bioanal Chem 399(1):3–27

    Article  PubMed  CAS  Google Scholar 

  5. Rice SL, Roney CA, Daumar P, Lewis JS (2011) The next generation of positron emission tomography radiopharmaceuticals in oncology. Semin Nucl Med 41(4):265–282

    Article  PubMed  Google Scholar 

  6. Coenen HH, Elsinga PH, Iwata R et al (2010) Fluorine-18 radiopharmaceuticals beyond [18F]FDG for use in oncology and neurosciences. Nucl Med Biol 37(7):727–740

    Article  PubMed  CAS  Google Scholar 

  7. Chen K, Conti PS (2010) Target-specific delivery of peptide-based probes for PET imaging. Adv Drug Deliv Rev 62(11):1005–1022

    Article  PubMed  CAS  Google Scholar 

  8. Harapanhalli RS (2010) Food and Drug Administration requirements for testing and approval of new radiopharmaceuticals. Semin Nucl Med 40(5):364–384

    Article  PubMed  Google Scholar 

  9. Ishiwata K, Kimura Y, Oda K et al (2010) Development of PET radiopharmaceuticals and their clinical applications at the Positron Medical Center. Geriatr Gerontol Int 10(Suppl 1):S180–S196

    PubMed  Google Scholar 

  10. Dingemanse J, Appel-Dingemanse S (2007) Integrated pharmacokinetics and pharmacodynamics in drug development. Clin Pharmacokinet 46:713–737

    Article  PubMed  CAS  Google Scholar 

  11. Pien HH, Fischman AJ, Thrall JH, Sorensen AG (2005) Using imaging biomarkers to accelerate drug development and clinical trials. Drug Discovery Today 10:259–266

    Article  PubMed  CAS  Google Scholar 

  12. Takimoto CH, Wick M (2007) Preclinical drug development, in: AJ Atkinson, DR Abernethy, CE Daniels et al (eds) Principles of Clinical Pharmacology, 2nd edn. Academic Press, San Diego

    Google Scholar 

  13. Singh SS (2007) Preclinical pharmacokinetics: an approach towards safer and efficacious drugs. Curr Drug Metab 7:165–182

    Article  CAS  Google Scholar 

  14. Korfmacher WA (2009) Advances in the integration of drug metabolism into the lead optimization paradigm. Mini Rev Med Chem 9:703–716

    Article  PubMed  CAS  Google Scholar 

  15. National Centre for the Replacement, Refinement and Reduction of Animals in Research (2007) Challenging requirement for acute toxicity studies: A workshop report http://www.nc3rs.org.uk/downloaddoc.asp?id=559&page=22&skin=0

    Google Scholar 

  16. EMEA-CPMP (2009) ICH Topic M3 (R2) Non-clinical safety studies for the conduct of human clinical trials and marketing authorization for pharmaceuticals (CPMP/ICH/286/95) http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500002720.pdf

    Google Scholar 

  17. Robinson S, Delongeas JL, Donald E et al (2008) A European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development. Regul Toxicol Pharmacol 50:345–352

    Article  PubMed  Google Scholar 

  18. Rudin M (2009) Noninvasive structural, functional, and molecular imaging in drug development. Curr Opinion Chem Biol 13:360–371

    Article  CAS  Google Scholar 

  19. Jain S, Dani P, Sharma RK (2009) Pharmacoscintigraphy: a blazing trail for the evaluation of new drugs and delivery systems. Crit Rev Ther Drug Carrier Syst 26:373–426

    Article  PubMed  CAS  Google Scholar 

  20. Del Guerra A, Belcari N, Llacer GL et al (2008) Advanced radiation measurement techniques in diagnostic radiology and molecular imaging. Radiat Prot Dosimetry 131:136–142

    Article  PubMed  Google Scholar 

  21. Kang JH, Chung JK (2008) Molecular-genetic imaging based on reporter gene expression. J Nucl Med 49(Suppl 2):164S–179S

    Article  PubMed  CAS  Google Scholar 

  22. Sauter AW, Wehrl HF, Kolb A et al (2010) Combined PET/MRI: one step further in multimodality imaging. Trends Mol Med 16(11):508–515

    Article  PubMed  Google Scholar 

  23. Rowland DJ, Cherry SR (2008) Small-animal preclinical nuclear medicine instrumentation and methodology. Semin Nucl Med 38(3):209–222

    Article  PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Italia

About this chapter

Cite this chapter

Duatti, A., Moresco, R.M., Boschi, S. (2013). Sperimentazione preclinica di radiofarmaci. In: Lucignani, G. (eds) Sperimentazione e registrazione dei radiofarmaci. Imaging & Formazione. Springer, Milano. https://doi.org/10.1007/978-88-470-2874-6_6

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-2874-6_6

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2873-9

  • Online ISBN: 978-88-470-2874-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics