Skip to main content
SpringerLink
Log in

Rare Secondary Tumors of the Pancreas

  • Chapter
Uncommon Pancreatic Neoplasms

Part of the book series: Updates in Surgery ((UPDATESSURG))

  • 1169 Accesses

Abstract

Secondary neoplasms involving the pancreas are less common than primary neoplasms. The pancreas is rarely the only metastatic site and metastases can reach the pancreas by lymphatic or hematogenous routes. Several tumors have been demonstrated to metastasize to the pancreas; however, there are differences in the prevalence of the various tumor types that colonize the pancreas, depending upon the population considered (autopsy records vs. surgical specimens).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Rock J, Bloomston M, Lozanski G, Frankel WL (2012) The spectrum of hematologic malignancies involving the pancreas: potential clinical mimics of pancreatic adenocarcinoma. Am J Clin Pathol 37:414-422

    Article  Google Scholar 

  2. Adsay NV, Andrea A, Basturk O et al (2004) Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature. Virchows Arch 444:527-535

    Article  PubMed  Google Scholar 

  3. Sweeney AD, Fisher WE, Wu MF et al (2010) Value of Pancreatic Resection for Cancer Metastatic to the Pancreas, J Surg Res 160:268-276

    Article  PubMed  Google Scholar 

  4. Washington K, McDonagh D (1994) Secondary tumors of the gastrointestinal tract: surgical pathologic findings and comparison with autopsy survey. Mod Pathol 8:427-433

    Google Scholar 

  5. Z’graggen K, Fernandez-del Castillo C, Rattner DW et al (1998) Metastases to the pancreas and their surgical extirpation. Arch Surg 133:413-418

    Article  PubMed  Google Scholar 

  6. Robbins EG II, Franceschi D, Barkin JS (1996) Solitary metastatic tumors to the pancreas: a case report and a review of the literature. Am J Gastroenterol 91:2414-2417

    PubMed  Google Scholar 

  7. Konstantinidis IT, Dursun A, Zheng H (2010) Metastatic tumors in the pancreas in the modern era. J Am Coll Surg 211:749-753

    Article  PubMed  Google Scholar 

  8. Moutardier V, Berthet B, Le Treut Y (1993) Metastase pancreatique d’une tumeur de Grawitz. J Chir (Paris) 130:439-440

    CAS  Google Scholar 

  9. Altschuler EL, Ray A (1998) Spontaneous regression of a pancreatic metastasis of a renal cell carcinoma. Arch Fam Med 7:516-517

    Article  PubMed  CAS  Google Scholar 

  10. Motzer RJ, Bander NH, Nanus DM (1996) Renal-cell carcinoma. N Engl J Med 335:865-875

    Article  PubMed  CAS  Google Scholar 

  11. Reddy S, Wolfgang CI (2009) The role of surgery in the management of isolated metastases to the pancreas. Lancet Oncol 10:287-293

    Article  PubMed  Google Scholar 

  12. Kassabian A, Stein J, Jabbour N (2000) Renal cell carcinoma metastatic to the pancreas: a single-institution series and review of the literature. Urology 56:211-215

    Article  PubMed  CAS  Google Scholar 

  13. Sellner F, Tykalsky N, De Santis M et al (2006) Solitary and multiple isolated metastases of clear cell renal carcinoma to the pancreas: an indication for pancreatic surgery. Ann Surg Oncol 13:75-85

    Article  PubMed  Google Scholar 

  14. Ward Y, Wang W, Woodhouse E et al (2001) Signal pathways which promote invasion and metastasis: critical and distinct contributions of extra-cellular signal-regulated kinase and Ralspecific guanine exchange factor pathways. Mol Cell Biol 21:5958-5969

    Article  PubMed  CAS  Google Scholar 

  15. Hiotis SP, Klimstra DS, Conlon KC, Brennan MF (2002) Results after pancreatic resection for metastatic lesions. Ann Surg Oncol 9:675-679

    Article  PubMed  Google Scholar 

  16. Le Borgne J, Partensky C, Glemain P et al (2000) Pancreaticoduodenectomy for metastatic ampullary and pancreatic tumors. Hepatogastroenterology 47:540-544

    PubMed  CAS  Google Scholar 

  17. Thompson LD, Heffess CS et al (2000) Renal cell carcinoma to the pancreas in surgical pathology material. Cancer 89:1076-1088

    Article  PubMed  CAS  Google Scholar 

  18. Fabre JM, Rouanet P, Dagues F et al (1995) Various features and surgical approach of solitary pancreatic metastasis from renal cell carcinoma. Eur J Surg Oncol 21:683-686

    Article  PubMed  CAS  Google Scholar 

  19. Tanis PJ, van der Gaag NA, Busch OR et al (2009) Systematic review of pancreatic surgery for metastatic renal cell carcinoma. Br J Surg 96:579-592

    Article  PubMed  CAS  Google Scholar 

  20. Faure JP, Tuech JJ, Richer JP et al (2001) Pancreatic metastasis of renal cell carcinoma: presentation, treatment and survival. J Urol 165:20-22

    Article  PubMed  CAS  Google Scholar 

  21. Law CH, Wei AC, Hanna SS et al (2003) Pancreatic resection for metastatic renal cell carcinoma: presentation, treatment, and outcome. Ann Surg Oncol 10:922-926

    Article  PubMed  Google Scholar 

  22. Sohn TA, Yeo CJ, Cameron JL et al (2001) Renal cell carcinoma metastatic to the pancreas: results of surgical management. J Gastrointest Surg 5:346-351

    Article  PubMed  CAS  Google Scholar 

  23. Mechó S, Quiroga S, Cuéllar H, Sebastià C (2009) Pancreatic metastasis of renal cell carcinoma: multidetector CT findings. Abdom Imaging 34:385-389

    Article  PubMed  Google Scholar 

  24. Flath B, Rickes S, Schweigert M et al (2003) Differentiation of pancreatic metastasis of a renal cell carcinoma from primary pancreatic carcinoma by echo-enhanced power Doppler sonography. Pancreatology 3:349-351

    Article  PubMed  CAS  Google Scholar 

  25. Megibow AJ (2003) Secondary pancreatic tumors: imaging. In: Procacci C, Megibow AJ (eds) Imaging of the pancreas. Cystic and rare tumors. Springer-Verlag: Berlin, pp 277-288.

    Google Scholar 

  26. Jenssen E (1952) A metastatic hypernephroma to the pancreas. Acta Chir Scand 104:177-180

    PubMed  CAS  Google Scholar 

  27. Ballarin R, Spaggiari M, Cautero N et al (2011) Pancreatic metastases from renal cell carcinoma: the state of the art. World J Gastroenterol 17:4747-4756

    Article  PubMed  Google Scholar 

  28. Zerbi A, Ortolano E, Balzano G et al (2008) Pancreatic metastasis from renal cell carcinoma: which patients benefit from surgical resection? Ann Surg Oncol 15:1161-1168

    Article  PubMed  Google Scholar 

  29. Motzer JR, Mazumdar M, Bacik J et al (1999) Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 17:2530-2540

    PubMed  CAS  Google Scholar 

  30. Bassi C, Butturini G, Falconi M et al (2003) High recurrence rate after atypical resection for pancreatic metastases from renal cell carcinoma. Br J Surg 90:555-559

    Article  PubMed  CAS  Google Scholar 

  31. Strobel O, Hackert T, Hartwig W et al (2009) Survival data justifies resection for pancreatic metastases. Ann Surg Oncol 16:3340-3349

    Article  PubMed  Google Scholar 

  32. Reddy S, Edil BH, Cameron JL et al (2008) Pancreatic resection of isolated metastases from nonpancreatic primary cancers. Ann Surg Oncol 15:3199-3206

    Article  PubMed  Google Scholar 

  33. Butturini G, Bassi C, Falconi M et al (1998) Surgical treatment of pancreatic metastases from renal cell carcinomas. Dig Surg 15:241-246

    Article  PubMed  CAS  Google Scholar 

  34. Motzer RJ, Hutson TE, Tomczak P et al (2007) Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356:115-124

    Article  PubMed  CAS  Google Scholar 

  35. Motzer RJ, Michaelson MD, Redman BG et al (2006) Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 24:16-24

    Article  PubMed  CAS  Google Scholar 

  36. Gore ME, Szczylik C, Porta C et al (2009) Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial. Lancet Oncol 10:757-763

    Article  PubMed  CAS  Google Scholar 

  37. Hudes G, Carducci M, Tomczak P et al (2007) Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 356:2271-2281

    Article  PubMed  CAS  Google Scholar 

  38. Motzer RJ, Escudier B, Oudard S et al (2008) Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 372:449-456

    Article  PubMed  CAS  Google Scholar 

  39. Sonpavde G, Hutson TE, Rini BI (2008) Axitinib for renal cell carcinoma. Expert Opin Investig Drugs 17:741-748

    Article  PubMed  CAS  Google Scholar 

  40. Rini BI, Escudier B, Tomczak P et al (2011) Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet 378:1931-1939

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery and Oncology, General Surgery Unit, Pancreas Center, “G.B. Rossi” University Hospital, Verona, Italy

    Giovanni Butturini

Authors
  1. Giovanni Butturini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marco Inama
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marco Dal Molin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mirko D’Onofrio
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Davide Melisi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Giampaolo Tortora
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Federica Pedica
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Paola Capelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Giovanni Butturini or Giovanni Butturini .

Editor information

Editors and Affiliations

  1. Department of Surgery and Oncology General Surgery Unit, Pancreas Center, “G.B. Rossi” University Hospital, Verona, Italy

    Paolo Pederzoli  & Claudio Bassi  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Italia

About this chapter

Cite this chapter

Butturini, G. et al. (2013). Rare Secondary Tumors of the Pancreas. In: Pederzoli, P., Bassi, C. (eds) Uncommon Pancreatic Neoplasms. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-2673-5_15

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-2673-5_15

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2672-8

  • Online ISBN: 978-88-470-2673-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation