Skip to main content
SpringerLink
Log in

Pharmacological Interactions in the Perioperative Period

  • Chapter
Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.

  • 169 Accesses

Abstract

Considering that patients admitted to a hospital are frequently given regular drug therapy (the incidence being 24%-42% overall and increasing to 70% in patients aged over 70 years) (1, 2), that each patient may receive on average 9.4 drugs during hospitalization (3), and, finally, that another ten or more drugs may be given for a “routine” anesthetic procedure, it is not surprising that the potential for perioperative drug interactions is very significant. Indeed, this risk has been estimated at 7% in patients taking six to ten drugs and 50% in patients taking more than ten drugs (4).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Duthie DJR, Montgomery JN, Spence AA, Nimmo WS (1987) Concurrent drug therapy in patients undergoing surgery. Anaesthesia 42:305–311

    Article  PubMed  CAS  Google Scholar 

  2. Kluger MT, Gale S, Plummer JL, Owen H (1991) Perioperative drug prescribing pattern and manufacturers’ guidelines. Anaesthesia 46:456–459

    Article  PubMed  CAS  Google Scholar 

  3. Lawson DH, Tick H (1976) Drug prescribing in hospitals: an international comparison. Am J Publ Health 66:644–648

    Article  CAS  Google Scholar 

  4. Dambro MR, Kallgren MA (1988) Drug interactions in a clinic using costar. Comput Biol Med 18:31–38

    Article  PubMed  CAS  Google Scholar 

  5. Yuen IH, Denman SL, Sokoloski TD, Burkman LM (1979) Loss of nitroglycerin from aqueous solution into plastic intravenous delivery systems. J Pharm Sci 68:1163–1166

    Article  PubMed  CAS  Google Scholar 

  6. Mutch WAC, Thomson IR (1983) Delivery systems for intravenous nitroglycerin. Can Anaesth Soc J 30:98–99

    Article  PubMed  CAS  Google Scholar 

  7. Koren G, Goresky G, Crean P, Klein J, MacLeod SM (1984) Pediatric fentanyl dosing based on pharmacokinetics during cardiac surgery. Anesth Analg 63:577–582

    Article  PubMed  CAS  Google Scholar 

  8. Cullen BF, Miller MG (1979) Drug interactions and anesthesia: a review. Anesth Analg 58:413–423

    PubMed  CAS  Google Scholar 

  9. Hindle AT, Columb MO, Shah MV (1995) Drug interactions and anaesthesia. Curr Anaesth Crit Care 6:103–112

    Article  Google Scholar 

  10. Nimmo WS, Heading RC, Wilson J, Tothill P, Prescott LF (1975) Inhibition of gastric emptying and drug absorption by narcotic analgesics. Br J Clin Pharmacol 2:509–513

    PubMed  CAS  Google Scholar 

  11. Gamble JAS, Gaston JH, Nair SG, Dundee JW (1976) Some pharmacological factors influencing the absorption of diazepam following oral administration. Br J Anaesth 48: 1181–1185

    Article  PubMed  CAS  Google Scholar 

  12. Lasser EC, Elizondo-Martel G, Granke RC (1963) Potentiation of pentobarbital anaesthesia by competitive protein binding. Anesthesiology 24:665–671

    Article  PubMed  CAS  Google Scholar 

  13. Kaukinen S, Eerola M, Ylitalo P (1980) Prolongation of thiopentone anaesthesia by probenecid. Br J Anaesth 52:603–607

    Article  PubMed  CAS  Google Scholar 

  14. Csogor SI, Kerek SF (1970) Enhancement of thiopentone anaesthesia by sulphafurazole. Br J Anaesth 42:988–990

    Article  PubMed  CAS  Google Scholar 

  15. Dale O, Nilsen OG (1984) Displacement of some basic drugs from human serum proteins by enflurane, halothane and their major metabohtes. Br J Anaesth 56:535–542

    Article  PubMed  CAS  Google Scholar 

  16. Wood M (1986) Plasma drug binding: implications for anesthesiologists. Anesth Analg 65: 786–804

    PubMed  CAS  Google Scholar 

  17. Ghoneim MM, Pandya H (1974) Plasma protein binding of bupivacaine and its interactions with other drugs in man. Br J Anaesth 46:435–438

    Article  PubMed  CAS  Google Scholar 

  18. McLain GE, Sipes IG, Brown BR Jr (1979) An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. Anesthesiology 51:321–326

    Article  PubMed  CAS  Google Scholar 

  19. Brown BR Jr, Sipes JC (1977) Biotransformation and hepatotoxicity of halothane. Biochem Pharmacol 26:2091–2094

    Article  PubMed  CAS  Google Scholar 

  20. Mazze RI, Woodruff RE, Heerdt ME (1982) Isoniazid-induced enflurane defluorination in humans. Anesthesiology 57:5–8

    Article  PubMed  CAS  Google Scholar 

  21. Sorkin EM, Ogawa GS (1981) Cimetidine potentiation of narcotic action. Drug Intell Clin Pharm 17:60–61

    Google Scholar 

  22. Lam AM (1981) Potentially lethal interaction of cimetidine and morphine. Can Med Assoc J 125:820

    PubMed  CAS  Google Scholar 

  23. Klotz U, Reimann I (1980) Delayed clearance of diazepam due to cimetidine. N Engl J Med 302:1012–1014

    Article  PubMed  CAS  Google Scholar 

  24. Salonen M, Aantaa E, Aaltonen L (1986) Importance of the interaction of midazolam and cimetidine. Acta Pharmacol Toxicol 56:91–95

    Google Scholar 

  25. Freely J, Wilkinson Gr, Wood AJJ (1981) Reduction of liver blood flow and propranolol metabohsm by cimetidine. N Engl J Med 304: 692–695

    Article  Google Scholar 

  26. Knapp AB, Maguire W, Keren G, Karmen A, Levitt B, Miura DS, Somberg JC (1983) The cimetidine-lidocaine interaction. Ann Intern Med 98:174–177

    PubMed  CAS  Google Scholar 

  27. Campbell MA, Plachetka JR, Jackson JE (1981) Cimetidine decreases theophylhne clearance. Ann Intern Med 95:68–69

    PubMed  CAS  Google Scholar 

  28. Hansen WE, Berti S (1983) The inhibition of acetylchohnesterase and pseudochohnesterase by cimetidine. Arzneimittelforschung 33:161–163

    PubMed  CAS  Google Scholar 

  29. Kambam JR, Dymond R, Krestow M (1987) Effect of cimetidine on duration of action of succinylchohne. Anesth Analg 66:191–192

    Article  PubMed  CAS  Google Scholar 

  30. Stirt AJ, Sperry RJ, DiFazio CA (1988) Cimetidine and succinylchohne: potential interactions and effect on neuromuscular blockade in man. Anesthesiology 69:607–608

    Article  PubMed  CAS  Google Scholar 

  31. Whittaker M (1980) Plasma Cholinesterase variants and the anaesthetist. Anaesthesia 35: 174–197

    Article  PubMed  CAS  Google Scholar 

  32. Viby-Mogensen J (1983) Cholinesterase and succinylchohne. Dan Med Bull 30:129–150

    PubMed  CAS  Google Scholar 

  33. Rogers KJ, Thornton JA (1969) The interaction between monoamine oxidase inhibitors and narcotic analgesics in mice. Br J Pharmacol 36:470–480

    PubMed  CAS  Google Scholar 

  34. Gibb D (1984) Drug interactions in anaesthesia. Clin Anaesthesiol 2:485–512

    CAS  Google Scholar 

  35. Janowsky EC, Risch SC, Janowsky DS (1986) Psychotropic agents. In: Smith NT, Corbascio AN (eds) Drug interactions in anesthesia. Lea and Febiger, Philadelphia, pp 261–281

    Google Scholar 

  36. Stoeckel H, Hengstmann JH, Schuttler J (1979) Pharmacokinetics of fentanyl as a possible explanation for recurrence of respiratory depression. Br J Anaesth 51:741–745

    Article  PubMed  CAS  Google Scholar 

  37. Calvey TN, Milne LA, Williams NE, Chan K, Murray GR (1983) Effect of antacids on the plasma concentration of phenoperidine. Br J Anaesth 55:535–539

    Article  PubMed  CAS  Google Scholar 

  38. Johnston RR, Eger II EI, Wilson CA (1976) A comparative interaction of epinephrine with enflurane, isoflurane, and halothane in man. Anesth Analg 55:709–712

    Article  PubMed  CAS  Google Scholar 

  39. Atlee JL, Roberts FL (1986) Thiopental and epinephrine-induced dysrhythmias in dogs anesthetized with enflurane or isoflurane. Anesth Analg 65:437–443

    Article  PubMed  CAS  Google Scholar 

  40. Horrigan RW, Eger II EI, Wilson CW (1978) Epinephrine-induced arrhythmias during enflurane anesthesia in man: a nonlinear dose-response relationship and dose-dependent protection from lidocaine. Anesth Analg 57:547–550

    PubMed  CAS  Google Scholar 

  41. Nakao S, Hirata H, Kagawa Y (1989) Effects of volatile anesthetics on cardiac calcium channels. Acta Anaesthesiol Scand 33:326–330

    Article  PubMed  CAS  Google Scholar 

  42. Durand PG, Lehot JJ, Foex P (1991) Calcium-channel blockers and anaesthesia. Can J Anaesth 38:75–89

    Article  PubMed  CAS  Google Scholar 

  43. Atlee JL, Hamann SR, Brownlee SW, Kreigh C (1988) Conscious state comparisons of the effects of the inhalation anesthetics and diltiazem, nifedipine, or verapamil on specialized atrioventricular conduction times in spontaneously beating dog hearts. Anesthesiology 68: 519–528

    Article  PubMed  CAS  Google Scholar 

  44. Quist Christensen L, Bonde J, Kampmann JP (1993) Drug interactions with inhalational anaesthetics. Acta Anaesthesiol Scand 37:231–244

    Article  Google Scholar 

  45. Prys-Roberts C (1980) Cardiovascular effects of beta-receptor antagonists during anaesthesia. In: Prys-Roberts C (ed) The circulation in anaesthesia, applied physiology and pharmacology. Blackwell Scientific, Oxford, pp 406–428

    Google Scholar 

  46. Philbin DM, Lowenstein E (1976) Lack of beta-adrenergic activity of isoflurane in the dog: a comparison of the circulatory effects of halothane and isoflurane after propranolol administration. Br J Anaesth 48:1165–1170

    Article  PubMed  CAS  Google Scholar 

  47. Sprague DH (1975) Severe bradycardia after neostigmine in a patient taking propranolol to control paroxysmal atrial tachycardia. Anesthesiology 42:208–210

    Article  PubMed  CAS  Google Scholar 

  48. Wolfson B, Freed B (1980) Influence of alcohol on anesthetic requirements and acute toxicity. Anesth Analg 59:826–830

    Article  PubMed  CAS  Google Scholar 

  49. Bruce DL (1983) Alcohohsm and anesthesia. Anesth Analg 62:84–96

    PubMed  CAS  Google Scholar 

  50. White PF (1982) Comparative evaluation of intravenous agents for rapid sequence induction — thiopental, ketamine, and midazolam. Anesthesiology 57:279–284

    Article  PubMed  CAS  Google Scholar 

  51. Tomicheck RC, Rosow CE, Philbin DM, Moss J, Teplick RS, Schneider RC (1983) Diazepam-fentanyl interaction. Hemodynamic and hormonal effects in coronary artery surgery. Anesth Analg 62:881–884

    Article  PubMed  CAS  Google Scholar 

  52. Bidwai AV, Stanley TH, Graves CL, Kawamura R, Sentker CR (1975) The effects of ketamine on cardiovascular dynamics during halothane and enflurane anesthesia. Anesth Analg 54: 588–592

    PubMed  CAS  Google Scholar 

  53. Salmenpera M, Peltola K, Takkunen O, Heinonen J (1983) Cardiovascular effects of pancuronium and vecuronium during high-dose fentanyl anesthesia. Anesth Analg 62: 1059–1064

    PubMed  CAS  Google Scholar 

  54. Ostergaard D, Engbaek J, Viby-Mogensen J (1989) Adverse reactions and interactions of the neuromuscular blocking drugs. Med Toxicol Adverse Drug Exp 4:351–368

    PubMed  CAS  Google Scholar 

  55. Fiekers JF (1983) Effects of the aminoglycoside antibiotics, streptomycin and neomycin, on neuromuscular transmission. J Pharmacol Exp Ther 225:487–495

    PubMed  CAS  Google Scholar 

  56. Singh YN, Marshall IG, Harvey AL (1982) Pre- and post-junctional blocking effects of aminoglycoside, polymyxin, tetracycline and lincosamide antibiotics. Br J Anaesth 54: 1295–1306

    Article  PubMed  CAS  Google Scholar 

  57. Ghoneim MM, Long JP (1970) The interaction between magnesium and other neuromuscular blocking agents. Anesthesiology 32: 23–27

    Article  PubMed  CAS  Google Scholar 

  58. Hill GE, Wong KC, Hodges MR (1977) Lithium carbonate and neuromuscular blocking agents. Anesthesiology 46:122–126

    Article  PubMed  CAS  Google Scholar 

  59. Laflin MJ (1977) Interaction of pancuronium and corticosteroids. Anesthesiology 47:471–472

    Article  PubMed  CAS  Google Scholar 

  60. Ghsson SN, El-Etr A, Lim R (1979) Prolongation of pancuronium-induced neuromuscular blockade by intravenous infusion of nitroglycerin. Anesthesiology 51:47–49

    Article  Google Scholar 

  61. Dretchen KL, Morgenroth III VH, Standaert EG, Walts LF (1976) Azathioprine: effects on neuromuscular transmission. Anesthesiology 45:604–609

    Article  PubMed  CAS  Google Scholar 

  62. Gramstad L, Gjerlow JA, Hysing ES, Rugstad HE (1986) Interaction of cyclosporin and its solvent, cremophor, with atracurium and vecuronium. Studies in the cat. Br J Anaesth 58: 1149–1155

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. V. A. Peduto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. D’Uva
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Anaesthesiology and Intensive Care, Trieste University School of Medicine, Trieste, Italy

    Antonino Gullo M.D. (Head) (Head)

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Italia, Milano

About this chapter

Cite this chapter

Peduto, V.A., D’Uva, R. (1996). Pharmacological Interactions in the Perioperative Period. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2203-4_5

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-2203-4_5

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-3-540-75014-7

  • Online ISBN: 978-88-470-2203-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation