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The Radiotherapist’s Point of View

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Surgery in Multimodal Management of Solid Tumors

Part of the book series: Updates in Surgery ((UPDATESSURG))

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Abstract

Radiotherapy has played a central role in the treatment of neoplasms since the discovery of X-rays, particularly with regard to organ preservation where mutilating procedures may be avoided.

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References

  1. Herskovich AMK, al-Sarraf M, Leichman L (1992) Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of esophagus. N Engl J Med 326:1593–1598

    Article  Google Scholar 

  2. Minsky BD (2006) Primary combined-modality therapy for esophageal cancer. Oncology (Williston Park) 20(5):497–505

    Google Scholar 

  3. Zhao KL, Wang Y, Shi XH (2003) Late course accelerated hyperfractionated radiotherapy for clinical T1-2 esophageal carcinoma. World J Gastroenterol 9:1374–1376

    PubMed  Google Scholar 

  4. Urba SG, Porringer MB, Turrisi A (2001) Randomized trial of pre-operative chemoradiation vs. surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol 19:305–313

    PubMed  CAS  Google Scholar 

  5. Bosset JF, Gignoux M, Triboulet JP et al (1997) Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of esophagus. N Engl J Med 337:161–167

    Article  PubMed  CAS  Google Scholar 

  6. Walsh TN, Noonan N, Hollywood D (1996) Comparison of multimodal therapy and surgery for esophageal carcinoma. N Engl J Med 335:462–467

    Article  PubMed  CAS  Google Scholar 

  7. Bonnetain F, Bouche O, Michel P (2006) A comparative longitudinal quality of life study using the Spitzer quality of life index in a randomized multicenter phase III trial (FFCD 91029) Ann Oncol 17:827–834

    Article  PubMed  CAS  Google Scholar 

  8. Harvey JC, Fleishman EH, Bellotti JE (1993) Intracavitary radiation in the treatment of advanced esophageal carcinoma: a comparison of high dose rate vs. low dose rate brachitherapy. J Surg Oncol 52:101–104

    Article  PubMed  CAS  Google Scholar 

  9. Macdonald JS, Smalley SR, Benedetti J et al (2001) Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 345:725

    Article  PubMed  CAS  Google Scholar 

  10. Zhang ZX, Gu XZ, Yin WB et al (1999) Ramdomized clinical trial on the combination of preoperative irradiation and surgery in the treatment of adenocarcinoma of gastric cardia (AGC). Report on 370 patients. Int J Radiat Oncol Biol Phys 44(5):1185

    Google Scholar 

  11. Ajani JA, Mansfield PF, Janjan N et al (2004) Multi-institutional trial of preoperative chemoradiotherapy in patients with potentially respectable gastric carcinoma. J Clin Oncol 22:2774–2780

    Article  PubMed  CAS  Google Scholar 

  12. Gunderson L, Tepper J (2007) Clinical radiation oncology, 2nd edn. Churchill Livingstone Elsevier, Philadelphia

    Google Scholar 

  13. Abe M, Takahashi M, Ono K (1988) Japan gastric trials on intraoperative radiation therapy. Int J Radiat Oncol Biol Phys 15(6): 1431–1433

    PubMed  CAS  Google Scholar 

  14. Smalley SS, Gunderson L, Tepper J et al (2002) Gastric surgical adjuvant radiotherapy consensus report. Rationale and treatment implementation. Int J Radiat Oncol Biol Phys 52:282

    Google Scholar 

  15. Pemberton L, Coote J, Perry V et al (2006) Adjuvant chemoradiotherapy for gastric carcinoma: dosimetric implications of conventional gastric bed irradiation and toxicity. Clinical Oncology 18:663–668

    Article  PubMed  CAS  Google Scholar 

  16. Soyfer V, Corn BW, Melamud A et al (2007) Three-dimensional non-coplanar conformal radiotherapy yields better results than traditional beam arrangements for adjuvant treatment of gastric cancer. Int J Radiat Oncol Biol Phys 2:364–369

    Google Scholar 

  17. Gastrointestinal Tumor Study Group (1987) Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Cancer 59:2006–2010

    Article  Google Scholar 

  18. Sohn TA, Yeo CJ, Cameron JL (2000) Resected adenocarcinoma of the pancreas — 616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg 4(6):567–579

    Article  PubMed  CAS  Google Scholar 

  19. Regine WF, Winter KW, Abrams R et al (2006) RTOG 9704 a phase III study of adjuvant pre and post chemoradiation (CRT) 5-FU vs. gemcitabine (G) for resected pancreatic adenocarcinoma. J Clin Oncol 24(Suppl 18):A-4007, 180s

    Google Scholar 

  20. Haddock MG, Swaminathan R, Foster NR et al (2007) Gemcitabine, cisplatin and radiotherapy for patients with locally advanced pancreatic adenocarcinoma: results of the North Central Cancer Treatment Group Phase II Study N9942. J Clin Oncol 25:2567–2572

    Article  PubMed  CAS  Google Scholar 

  21. Morris SL, Beaslye M, Leslie M et al (2004) Chemotherapy for pancreatic cancer. N Engl J Med 350:2713

    Article  PubMed  CAS  Google Scholar 

  22. Regine WF, Winter KW, Abrams R et al (2006) RTOG 9704, a phase III study of adjuvant pre-and post-chemoradiation (CRS) 5-FU vs. gemcitabine (G) for resected pancreatic adenocarcinoma. J Clin Oncol 185:4007

    Google Scholar 

  23. Spitz FR, Abbruzzese JL, Lee JL (1997) Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas. J Clin Oncol 15(3):928–937

    PubMed  CAS  Google Scholar 

  24. Hoffmann JP, Cooper HS, Nancy A (1998) Preoperative chemoterapy of chemoradiotherapy of treatment of adenocarcinoma of the pancreas and ampulla of Vater. J Hepatobil Pancr Surg 5:251–252

    Article  Google Scholar 

  25. Moertel CG, Frytak S, Hahn RG (1981) Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose radiation alone, moderate dose radiation and high dose radiation + 5-fluorouracil. The Gastrointestinal Tumor Study Group. Cancer 48:1705–1710

    Article  PubMed  CAS  Google Scholar 

  26. Oettle H, Neuhaus P (2007) Adjuvant therapy in pancreatic cancer: a critical appraisal. Drugs 67(16):2293–2310

    Article  PubMed  CAS  Google Scholar 

  27. Li CP, Chao Y, Chi KH et al (2003) Concurrent chemoradiotherapy treatment of locally advanced pancreatic cancer: gemcitabine vs. 5-fluorouracil, a randomized controlled study. Int J Radiat Oncol Biol Phys 57(1):98–104

    PubMed  CAS  Google Scholar 

  28. Milano MT, Chmura SJ, Garafalo MC (2004) Intensity-modulated radiotherapy in treatment of pancreatic and bile duct malignancies: toxicity and clinical outcome. Int J Radiat Oncol Biol Phys 59:445

    PubMed  Google Scholar 

  29. Gastrointestinal Tumor Study Group (1984) Adjuvant therapy of colon cancer. Results of a prospectively randomized trial. N Engl J Med 312:1465

    Google Scholar 

  30. O’Connel MJ, Martenson JA, Wiland HS et al (1994) Improving adjuvant therapy for rectal cancer by combining protected infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med 331:502–507

    Article  Google Scholar 

  31. O’Connell MJ (2002) Improving adjuvant therapy in stage II and III rectal cancer to define the optimal sequence of chemotherapy and radiotherapy: a preliminary report. J Clin Oncol 20:1751–1758

    Article  Google Scholar 

  32. Bosset JF (2004) Does the addition of chemotherapy to preoperative radiotherapy increase the pathological response in patients with resected rectal cancer? Proc ASCO 22:247

    Google Scholar 

  33. Sauer R, Becker H, Homenberger W et al (2004) Preoperative chemoradiotherapy as compared with postoperative chemoradiotherapy for locally advanced rectal cancer. New Engl J Med 351:11–20

    Article  Google Scholar 

  34. Nagtegaal ID, Quirke P (2008) What is the role for the circumferential margin in the modern treatment of rectal cancer? J Clin Oncol 26(2):303–312

    Article  PubMed  Google Scholar 

  35. Roedel C (2004) Tumor regression grade as a prognostic factor in patients with locally advanced rectal cancer treated with preoperative radiochemotherapy. Int J Radiat Oncol Biol Phis 60(1):S140

    Google Scholar 

  36. Bonnen M, Crane C, Vauthey JN et al (2004) Long term results using local excision after preoperative chemoradiation among selected T3 rectal cancer patients. Int J Radiat Oncol Biol Phys 60(4): 1098–1105

    PubMed  Google Scholar 

  37. Larson SM, Schoder H, Yeung H (2004) Positron emission tomography / computerized tomography functional imaging of esophageal and colorectal cancer. Cancer J 10:243–250

    Article  PubMed  Google Scholar 

  38. Suzuki K, Dozois RR, Devine RM (1996) Curative reoperations for locally recurrent rectal cancer. Dis Colon Rectum 39(7):730–736

    Article  PubMed  CAS  Google Scholar 

  39. Valentini V, Morganti AG, De Franco A (1999) Chemoradiation with or without intraoperative radiation therapy in patients with locally recurrence of rectal carcinoma: prognostic factors and long term outcome. Cancer 86(12):2612–2624

    Article  PubMed  CAS  Google Scholar 

  40. Ryan DP, Compton CC, Mayer RJ (2000) Carcinoma of the anal canal. N Engl J Med 342:792–800

    Article  PubMed  CAS  Google Scholar 

  41. Nigro ND, Seydal HG, Considine B et al (1983) Combined preoperative radiation and chemotherapy for squamous-cell carcinoma of the anal canal. Cancer 51(10):1826–1829

    Article  PubMed  CAS  Google Scholar 

  42. Crehange G, Bosset M, Lorchel F et al (2006) Combining cisplatin and Mitomycin with radiotherapy in anal carcinoma. Dis Colon Rectum 50:43–49

    Article  Google Scholar 

  43. Ajani JA, Winter KA, Gunderson LL et al (2006) Intergroup RTOG 98-11: a phase III randomized study of 5-fluorouracil (5-FU), mitomycin, and radiotherapy vs. 5-FU cisplatin and radiotherapy in carcinoma of the anal canal. J Clin Oncol 24: 18S, abstract 4009

    Article  Google Scholar 

  44. Konski AA, Winter K, John M et al (2007) Evaluation of planned treatment breaks during radiation therapy for anal cancer: update of Radiation Therapy Oncology Group (RTOG) 92-08. J Clin Oncol Gastrointestinal Cancers Symposium. Abstract 297

    Google Scholar 

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Authors and Affiliations

  1. UOC Chirurgia A, Sant’Andrea Hospital, University of Rome “La Sapienza”, Rome, Italy

    Riccardo Maurizi Enrici, Mattia F. Osti & Francesca Berardi

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  1. Riccardo Maurizi Enrici
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  2. Mattia F. Osti
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  3. Francesca Berardi
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© 2009 Springer-Verlag Italia

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Enrici, R.M., Osti, M.F., Berardi, F. (2009). The Radiotherapist’s Point of View. In: Surgery in Multimodal Management of Solid Tumors. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-1085-7_6

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  • DOI: https://doi.org/10.1007/978-88-470-1085-7_6

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1084-0

  • Online ISBN: 978-88-470-1085-7

  • eBook Packages: MedicineMedicine (R0)

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