Abstract
Surgery is the fundamental treatment option in most solid tumors, but it is no longer the sole therapeutic weapon available. Instead it needs to be integrated in a considerably more complex multidisciplinary strategy, with two main aims: — To guarantee recovery and increase the duration of survival through the control of the disease, not only at the local-regional level, but also in general — To guarantee good quality of life by means of the most conservative possible treatment which maintains organ function and a good image of the organism.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Wiggers T, Jeekel J, Arends JW et al (1988) No-touch isolation tecnique in colon cancer: a controlled prospective trial. Br J Surg 75(5):409–415
Salsbury AJ (1975) The significance of the circulating cancer cell. Cancer Treat Rev 2(1):55–72
Sugarbaker PH, Corlew S (1982) Influence of surgical techniques on survival in patients with colorectal cancer. Dis Colon Rectum 25(6):545–557
Glaves D, Hubert RP, Weiss L (1988) Hematogenous dissemination of cells from human renal carcinomas. Br J Cancer 57: 32–35
Vlems FA, Ruers T J, Punt CJ et al (2003) Relevance of disseminated tumor in blood bone marrow of patients with solid epithelial tumors in perspective. EJSO 29:289–302
Klein CA, Blankestein TJ, Schmidr-Kittler O et al (2002) Genetic heterogenecity of single disseminated tumour cells in minimal residual cancer. Lancet 360:689–699
Fisher B, Fisher ER (1967) Barrier function of lymph node to tumor cells and erythrocytes. Cancer 20:1907–1913
Isono K, Sato H, Nakayama K (1991) Results of a nationwide study on the three-field lymph node dissection of esophageal cancer. Oncology 48(5):411–420
Hermanek P, Altendorf A (1981) Classification of colorectal carcinomas with regional lymphatic metastases. Pathol Res Pract 173(1-2): 1–11
Hermanek P, Hutter RV, Sobin LH, Wagner G (1997) International Union Against Cancer. TNM atlas, IV edition. Springer, Berlin Heidelber New York
Hermanek P, Giegel P, Dworak O (1989) Two programs for examination of regional lymph nodes in colorectal carcinoma with regard to the new pN classification. Pathos Res Pract 185:867–872
Herrera L, Villareal JR (1992) Incidence of metastases from rectal adenocarcinoma in small lymph nodes detected by a clearing tecnique. Dis Colon Rectum 35(8):783–788
Morikawa E, Yasutomi M, Shindou K et al (1994) Distribution of metastatic lymph nodes in colorectal cancer by the modified clearing method. Dis Colon Rectum 37(3):219–223
Greenson JK, Isenhart CE, Rice R et al (1994) Identification of occult micrometastases in pericolic lymph nodes of Duke’s B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49. Correlation with longterm survival. Cancer 73(3):563–569
Raj GV, Moreno JG, Gomella LG (1998) Utilization of polymerase chain reaction technology in the detection of solid tumors. Cancer 82:1419
Hayashi N, Ito I, Yanagisawa A et al (1995) Genetic diagnosis of lymph-node metastasis in colorectal cancer. Lancet 345(8960): 1257–1259
Lindemann F, Schlimok G, Dirschell P (1992) Prognostic significance of micrometastatic tumor cells in bone marrow of colorectal cancer patients. Lancet 340(8821):685–689
Braun S, Pantel K, Muller P et al (2000) Cytokeratine-positive cells in bone marrow and survival of patients with stage I, II, or III breast cancer. N Engl J Med 342:525–533
Hosh SB, Braun S, Pantel K (2001) Characterization of disseminated tumor cells. Sem Surg Oncol 20:267–271
Hansen R, Wolf N, Knuechel R et al (1995) Tumor cells on blood shed from the surgical field. Arch Surg 130:387–393
Yamamoto K, Murae M, Yasuda M (1991) RGD-Containing peptides inhibit experimental peritoneal acceding of human ovarian cancer cells. Nippon Sanka Fujinka Gakkai Zasshi 43(12): 1687–1692
Elias D, Gachot B, Bonvallot S et al (1997) Peritoneal carcinosis treated by complete excision and immediate postoperative intraperitoneal chemotherapy. Phase II study in 54 patients. Gastroenterol Clin Biol 21(3): 181
Elias D, Cavalcanti A, Sabourin JC et al (1998) Results of 136 curative hepatectomies with a safety margin of less than 10mm for colorectal metastases. J Surg Oncol 69:88–93
Koo J, Fung K, Siu KF et al (1983) Recovery of malignant tumor cells from the right atrium duting hepatic resection for hepatocellular carcinoma. Surgery 52:1952–1956
Slade NS, Simmons RL, Yunis E (1975) Immunodepression after major surgery in normal patients. Surgery 78:363–372
Elias D, Farace F, Triebel F et al (1995) Phase I-II randomized study on pre-hepatectomy recombinant inerleukin-2 in patients with metastasis carcinoma of the colon and rectum. J Am Coll Surg 181:303–310
Baker DG, Masterson TM, Pacer R et al (1989) The influence of the surgical wound on local recurrence. Surgery 106:525–532
Elias D, Lasser P, Rougier P et al (1987) Early adjuvant intraportal chemotheraphy after curative hepatectomy for colorectal liver metastases. A pilot study. Eur J Surg Oncol 13:247–250
Romano F, Cesana G, Berselli M et al (2004) Biological histological, and clinical impact of preoperative IL-2 administration in radically operable gastric cancer patients. J Surg Oncol 88:240–247
Elias D (1992) La chirurgie dite de réduction tumorale: mythe ou realité? J Chir (Paris) 129:479–483
André T, Boni C, Mounedji-Boudiaf L et al (2004) Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 350:2343–2351
Moertel CG, Fleming TH, Mac Donald JS et al (1990) Levamisole and fluorouracil for adjuvant therapy of resected carcinoma. N Engl J Surg 322:352–358
Elias D, Oueller JF (2001) Intraperitoneal chemohyperthermia. Rationale, technique, indication, and results. Surg Oncol Clin N Am 10:915–933
Verwaal VC, van Ruth S, de Bree E et al (2003) Randomized trial of cytoreduction and hypertermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery with peritoneal carcinomatosis from colorectal cancer. J Clin Oncol 21:3737–3743
Elias D, Sideris I, Pocard M et al (2004) Efficacy of intraperitoneal chemohypertermia with oxaliplatin in colorectal peritoneal carcinomatosis. Preliminary results in 24 patients. Ann Oncol 15:781–785
Adam R, Pascal G, Castaing D et al (2004) Tumor progression while on chemotherapy. A contraindication to liver resection for multiple colorectal metastases? Ann Surg 240:1052–1064
Peeters C, de Geus LF, Wetphal JR et al (2005) Decrease in circulating anti-angiogenic factor after removal of primary colorectal carcinoma coincides with increased metabolic activity of liver metastases. Surgery 137:246–249
Marie P, Cluner J (1910) Frequence des metastases viscérales chez les souri cancéreuses après ablation chirurgicale de leur tumeur. Bull Assoc Fr Etud Cancer 3:19–23
Buinauskas P, Mc Donald GO, Cole Wh (1958) Role of operative stress on the resistance of the experimental animal to inoculated cancer cells. Ann Surg 148:642–650
Murthy MS, Scanlon EF, Reid JK, Yang XF (1996) Pre, peri and postoperative chemotherapy for breast cancer: is one better than the other? J Surg Oncol 61:273–277
Elias D, Bonnay M, Puizzillou JM et al (2002) Heated intra-operative intraperitoneal oxaliplatin after complete resection of peritoneal carcinomatosis: pharmacokinetics and tissue distribution and tolerance. Ann Oncol 13:267–272
Elias D, Matsuhina T, Sideris L et al (2004) Heated intraoperative intraperitoneal oxaliplatin plus irinotecan after complete resection of peritoneal carcinomatosis: pharmacokinetics, tissue distribution and tolerance. Ann Oncol 15:1558–1565
Elias D, Liberale G, Vernerey D et al (2005) Hepatic and extrahepatic colorectal metastases: when resectable, their localization does not matter, but their total number has a prognostic impact. Ann Surg Oncol 12:900–909
Elias D, Youssef O, Sideris L et al (2004) Evolution of missing colorectal liver metastases following inductive chemotherapy and hepatectomy. J Surg Oncol 86:4–9
Weed DL, Greenwald P, Cullen JW (1990) The future of cancer prevention and control. Semin Oncol 17(4):504–509
Brown PD, Giavazzi R (1995) Matrix metalloproteinase inhibition: a review of anti-tumor activity. Ann Oncol 6(10):967–974
Folkman J (1997) Angiogenesis and angiogenesis inhibition: an overview. EXS 79:1–8
O’Relly MS, Holmgren L, Chen C, Folkman J (1996) Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med 2(6):689–692
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Italia
About this chapter
Cite this chapter
Bolognese, A., Elias, D. (2009). Surgery and Tumors. In: Surgery in Multimodal Management of Solid Tumors. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-1085-7_2
Download citation
DOI: https://doi.org/10.1007/978-88-470-1085-7_2
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-1084-0
Online ISBN: 978-88-470-1085-7
eBook Packages: MedicineMedicine (R0)