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Molecular Modifications Induced by Physical Exercise: A Significant Role in Disease Prevention

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Role of Physical Exercise in Preventing Disease and Improving the Quality of Life

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Abstract

The pathogenesis of metabolic syndrome is at present only partly understood; however, a sedentary lifestyle, an unhealthy diet, being overweight or obese, and still largely unknown genetic factors clearly interact to cause it [1,2]. People suffering from metabolic syndrome share three or more of the following characteristics: augmented waist circumference, elevated plasma triglycerides, low levels of high-density lipoprotein, increased waist circumference, glucose intolerance, and hypertension. Although several studies point to insulin resistance as the principal cause in the development of metabolic syndrome and cardiovascular disease, a growing body of evidence highlights the importance of aerobic capacity as a predictor of metabolic syndrome and cardiovascular diseases [3–5]. Aerobic capacity, how well an organism can metabolize oxygen and generate energy, depends on the efficiency of oxygen delivery to tissues and the subsequent effectiveness of respiration carried out by mitochondria in those tissues, especially in skeletal muscle.

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Authors and Affiliations

  1. Institute of Health and Physical Exercise, University of Urbino “Carlo Bo”, Urbino, Italy

    Michele Guescini & Laura Stocchi

  2. Department of Internal Medicine Section Internal Medicine Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy

    Chiara Di Loreto, Cristina Fatone & Pierpaolo De Feo

  3. Institute of Biological Chemistry “Giorgio Fornaini” and Institute of Health and Physical Exercise, University of Urbino “Carlo Bo”, Urbino, Italy

    Vilberto Stocchi

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  1. Michele Guescini
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  2. Laura Stocchi
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  3. Chiara Di Loreto
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  4. Cristina Fatone
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  5. Pierpaolo De Feo
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  6. Vilberto Stocchi
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Editors and Affiliations

  1. Institute of Biological Chemistry “Giorgio Fornaini” and Institute of Health and Physical Exercise, University of Urbino “Carlo Bo”, Urbino, Italy

    Vilberto Stocchi

  2. Department of Internal Medicine Section of Internal Medicine Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy

    Pierpaolo De Feo

  3. School of Kinesiology Science Department of Biology, York University, Toronto, Ontario, Canada

    David A. Hood

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Guescini, M., Stocchi, L., Di Loreto, C., Fatone, C., De Feo, P., Stocchi, V. (2007). Molecular Modifications Induced by Physical Exercise: A Significant Role in Disease Prevention. In: Stocchi, V., De Feo, P., Hood, D.A. (eds) Role of Physical Exercise in Preventing Disease and Improving the Quality of Life. Springer, Milano. https://doi.org/10.1007/978-88-470-0376-7_5

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