Abstract
In the last years, there has been an increasing interest by the population for less aggressive approaches when reaching for in vitro fertilization (IVF) treatments. At the same time, the development of high-quality laboratories, with improved technology and high pregnancy rates, is encouraging infertility specialists to go back in time and practise the oldest IVF treatment approach, IVF using the natural unstimulated cycle (Steptoe and Edwards 1978).
The natural cycle IVF approach has many benefits. To name some of them, it is safe, drug-free, has close to zero multiple pregnancy rate, low time consumption, low cost, but is pretty unpopular, because of the relative high risk of premature ovulation, with low pregnancy rates per initiated cycle when compared to conventional protocols with pituitary desensitization.
The use of non-steroidal anti-inflammatory drugs (NSAIDs) during the ovulation process is studied as an effective drug for delaying or even blocking the follicle rupture. With this objective, NSAIDs can be used before egg retrieval to lower premature ovulation rates and increase egg retrieval rates.
The aim of this chapter is to give the infertility specialist a useful tool that could help them to achieve better results, lowering the risk of premature ovulation and higher egg retrieval, resulting in higher pregnancy rates per initiated cycle.
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Voget, J.M., Nitzschke, M. (2015). The Role of Non-steroidal Anti-inflammatory Drugs in Natural Cycle IVF. In: Allahbadia, G., Nitzschke, M. (eds) Minimal Stimulation and Natural Cycle In Vitro Fertilization. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1118-1_5
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DOI: https://doi.org/10.1007/978-81-322-1118-1_5
Publisher Name: Springer, New Delhi
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