Abstract
Several studies have shown that the implantation potential of oocytes derived from natural cycle IVF (NC-IVF) seems to be higher compared to conventional gonadotropin stimulated IVF (cIVF). The following chapter first describes that this difference might be due to differences in the follicular endocrine milieu in NC-IVF and cIVF. Intrafollicular concentration of androgens and the implantation marker anti-Müllerian hormone (AMH) are significantly higher in NC-IVF. These differences are possibly due to suppressed luteinizing hormone (LH) production in cIVF.
The chapter also describes a treatment protocol which is most cost-effective and promises the lowest possible treatment costs per achieved pregnancy. Using such an optimized treatment protocols with only 1.2 consultations before aspiration, with follicle aspiration without the use of analgesics, with flushing of the follicles, and with a pregnancy rates of 13 % per cycle, NC-IVF treatment requires around 1/3 more time to achieve a pregnancy but treatment costs per achieved pregnancy are lower than in cIVF.
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von Wolff, M. (2015). Natural Cycle IVF: Follicle Physiology and Treatment Costs. In: Allahbadia, G., Nitzschke, M. (eds) Minimal Stimulation and Natural Cycle In Vitro Fertilization. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1118-1_3
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DOI: https://doi.org/10.1007/978-81-322-1118-1_3
Publisher Name: Springer, New Delhi
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