Abstract
The major histocompatibility complex (MHC) molecules play crucial role in the regulation of the immune response by communicating among different cellular components of the immune system (Lamont, Poult Sci 77:1111–1118, 1998). Chicken (Gallus gallus) has been developed into an important experimental animal model for implicating MHC genes in resistance to infectious diseases and economic traits (Schat et al., Poult Sci 73:502–508, 1994). As the process of evolution in this region takes place over long periods of time that cannot be observed directly, phylogenetic analysis with present-day species and breeds could help. The evolutionary links between various domesticated birds were analysed using tree construction distance methods such as neighbour-joining (N-J) and UPGMA (unweighted pair group method with arithmetic mean) and character-based methods like maximum likelihood and maximum parsimony by MEGA version 5.05. The genetic distance was analysed using the same software. The phylogenetic analyses using various methods produced near identical topologies. The genetic distance analysis was in accordance with the tree studies providing a clear overview upon the evolutionary changes of the MHC gene under analysis, i.e. MHC B-L Beta 2.
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The authors of nucleotide sequence accession numbers from data bank utilized in the analysis are acknowledged.
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Kizhakkayil, S., Raveendran, A., Variyar, E.J. (2012). Evolutionary Genomics of Avian MHC BLB2 Gene by Molecular Phylogenetic Analysis. In: Sabu, A., Augustine, A. (eds) Prospects in Bioscience: Addressing the Issues. Springer, India. https://doi.org/10.1007/978-81-322-0810-5_15
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DOI: https://doi.org/10.1007/978-81-322-0810-5_15
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