Abstract
Understanding the feeding regulatory mechanisms that occur in upstream of obesity is important for the effective treatment of life-style related diseases. Feeding is regulated by complex interactions between orexigenic substances and anorectic substances, which are produced in the central nervous system and peripheral organs. Information about satiety or hunger is transmitted humorally and neurogenically to the brain, where it is integrated with various neural processes in the hypothalamus, such as learning, memory, cognition, and motion perception, and affects the feeding enhancement system or feeding inhibitory system. For feeding regulation, information is obtained not only from the central nervous system, including the hypothalamus and the cerebral limbic system, but also from peripheral organs, including the gastrointestinal tract, liver and adipose tissue. Afferent information from the gastrointestinal tract, liver, and adipose tissue concerning feeding and energy homeostasis is transmitted to the brain stem and hypothalamus through the vagus nerve and the circulatory system. Interestingly, the vagus afferent nerve expresses various receptors for substances that regulate feeding and is controlled by multiple factors.
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Nakazato, M., Ueno, H. (2008). Neuronal Mechanisms of Feeding Regulation by Peptides. In: Miyazaki, A., Imawari, M. (eds) New Frontiers in Lifestyle-Related Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-76428-1_2
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DOI: https://doi.org/10.1007/978-4-431-76428-1_2
Publisher Name: Springer, Tokyo
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