Summary
We have previously found that one of the kampo (Japanese herbal) medicines, Juzen-Taiho-To (TJ-48), accelerates recovery from hemopoietic injury induced by radiation and an anti-cancer drug. n-Hexane-soluble substances from TJ-48 showed significant stimulatory activity on the proliferation of hemopoietic stem cells in vitro Chromatographic separation and spectrometric identification using NMR and GC-MS revealed that the active fraction of TJ-48, which contained fatty acids such as oleic, linoleic and linolenic acids, accelerated stem cell proliferation. Oral administration of oleic acid to mitomycin C-treated mice enhanced CFU-S counts on day 14 to twice the control group. When the fatty acid composition of TJ-48 was compared with other kampo medicines, the same active fatty acids were detected even in other kampo prescriptions which had not been found to accelerate recovery from hemopoietic injury, but in different ratios. Although not all kampo medicines tested showed the stimulatory activity, their fatty acid fractions did. These results suggest that hemopoietic stimulation by TJ-48 might be the result of the combined effect of the active unsaturated fatty acids and other hydrophilic ingredients.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Nabeya K, Ri S (1983) Effect of oriental medical herbs on the restoration of the human body before and after operation. Proc Symp Wakan-Yaku 16: 201
Komatsu Y, Takemoto N, Maruyama H, Tsuchiya H, Aburada M, Hosoya E, Shinohara S, Hamada H (1986) Effect ofJuzentaihoto on the anti-SRBC response in mice. Jap J Inflammat 6: 405–408
Takemoto N, Kawamura H, Maruyama H, Komatsu Y, Aburada M, Hosoya E (1989) Jap J Inflammat 9: 49–52
Maruyama H, Kawamura H, Takemoto N, Komatsu Y, Aburada M, Hosoya E (1988) Effect of Kampo medicines on phagocytes. Jap J Inflammat 8: 65–66
Takemoto N, Kawamura H, Komatsu Y, Aburada M, Hosoya E (1989) Jap J Inflammat 9: 137–140
Ikehara S, Kawamura H, Komatsu Y, Yamada H, Hisha H, Yasumizu R, Ohnishi-Inoue Y, Kiyohara H, Hirano M, Aburada M, Good RA (1992) Effect of Medicinal plants on hemopoietic cells. Microbial Infections H. Fredman et al.(Eds), Plenum press, New York; pp 319–330
Kiyohara H, Takemoto N, Komatsu Y, Kawamura H, Hosoya E, Yamada H (1991) Charactarization of mitogenic pectic polysaccharides from Kampo (Japanese Herbal) Medicine “Juzen-Taiho-To” Planta Med 57: 254–259
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag Tokyo
About this paper
Cite this paper
Sakurai, M. et al. (1996). Hemopoietic Stem Cell-stimulating Ingredients in Kampo (Japanese Herbal) Medicine “Juzen-Taiho-To”. In: Ikehara, S., Takaku, F., Good, R.A. (eds) Bone Marrow Transplantation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68320-9_7
Download citation
DOI: https://doi.org/10.1007/978-4-431-68320-9_7
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68322-3
Online ISBN: 978-4-431-68320-9
eBook Packages: Springer Book Archive