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Role of cytoskeleton in the histamine release from mast cells

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New Advances in Histamine Research

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Abstract

It has been supposed by several investigators that cytoskeleton is involved in the exocytosis of rat mast cells, though conclusive evidence has·not been submitted (Gillespie et al., 1968; Rölich, 1975). Recently, three-dimensional images of a subplasmalemmal network and granules surrounded by a small-meshed network in the same cell have been shown by Nielsen and Jahn (1984). In addition, the existence of. actin filaments in the mast cells was reported by Tasaka et al. (1986a). In resting cells, actin immunofluorescence appeared as a net-like formation surrounding each granule. After stimulation with secretagogues, the distribution of the actin filaments became very irregular and disordered. In immunoelectron microscopy, patches of anti-actin immunogold particles were observed in the perigranular, nucleus and cell membranes. Curiously enough, a dense distribution of immunogold particles was often observed in the microvilli and on the surface of extruded granules (Tasaka et al., 1986a). This finding indicates that the actin located on the cell surface probably participates in exocytosis. In order to study more precisely the events leading to degranulation, this study was performed.

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Authors and Affiliations

  1. The Department of Pharmacology in the Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-Naka, 700, Okayama, Japan

    Kenji Tasaka M.D., PH.D. (Chairman and Professor)

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  1. Kenji Tasaka M.D., PH.D.
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© 1994 Springer-Verlag Tokyo

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Tasaka, K. (1994). Role of cytoskeleton in the histamine release from mast cells. In: New Advances in Histamine Research. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68263-9_5

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  • DOI: https://doi.org/10.1007/978-4-431-68263-9_5

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68265-3

  • Online ISBN: 978-4-431-68263-9

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