Summary
We measured the content of monoamine neurotransmitters in kaolin-induced hydrocephalic in rat brain. The effects of neurotransmitter changes in hydrocephalic rat brain after injection of a cerebral metabolic activator (bifemelane hydrochloride) are also discussed.
In this study, norepinephrine (NE), dopamine (DA), and serotonin (5-HT) content were determined in several brain regions including the cerebral cortex, striatum, hippocampus, cerebellum, pons, and medulla oblongata.
Bifemelane hydrochloride (bifemelane) was injected intraperitoneally daily for seven days beginning from the seventh day after kaolin injection and measurement was carried out on 15th day during the subacute phase of hydrocephalus.
As a result of the experimental studies, it was recognized that the content of some monoamines following injection of bifemelane was significantly different from the control values in some brain regions. In particular, differences in the cerebral cortex and striatum were significant.
This study demonstrates the effects of injection of a cerebral metabolic activator (bifemelane) on monoamine neurotransmitters in kaolin-induced hydrocephalus in the rat brain.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Andersson H, Roos BE (1965) Acidic monoamine metabolites in cerebrospinal fluid of children with hydrocephalus. Acta Neurol Scand 41(suppl 13): 149–151
Chovanes GI, McAllister JP II, Lamperti AA, Salotto AG, Truex RC (1988) Monoamine alterations during experimental hydrocephalus in neonatal rats. Neurosurgery 22: 86–91
Del Bigio MR (1989) Hydrocephalus-induced changes in the composition of cerebrospinal fluid. Neurosurgery 25: 416–423
Gonzalez-Darder J, Barbera J, Cerda-Nicolas M, Segura D, Broseta J, Barcia-Salorio JL (1984) Sequential morphological and functional changes in kaolin-induced hydrocephalus. J Neurosurg 61: 918–924
Goto Y, Taki W, Kikuchi H (1988) Effects of bifemelane on the free fatty acid levels during ischemia (in Japanese). No To Shinkei 40: 1045–1049
Higashi K, Asahisa H, Ueda N, Kobayashi K, Hara K, Noda Y (1986) Cerebral blood flow and metabolism in experimental hydrocephalus. Neurol Res 8: 169–176
Miwa S, Inagaki C, Fujiwara M, Takaori S (1982) The activities of noradrenergic and dopaminergic neuron systems in experimental hydrocephalus. J Neurosurg 57: 67–73
Ogura K, Shibuya M, Kanamori M, Suzuki Y, Ikegaki I, Harada T, Okasa T, Tanoi C, Kageyama N (1988) Changes of monoamine neurotransmitter metabolism in brain ischemia measured by in vivo voltametry (in Japanese). No To Shinkei 40: 87–93
Onodera Y, Saitoh Y, Sakata M, Itoh H, Miwa T (1988) Quantitative fatty acid composition and monoamine metabolites in CSF from congenital hydrocephalic children during the myelination period (in Japanese). Nerv Syst Child 13: 7–13
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Tokyo
About this paper
Cite this paper
Miyake, H., Eghwrudjakpor, P., Sakamoto, T., Kurisaka, M., Mori, K. (1991). Neurotransmitter Changes in Hydrocephalus: Effects of Cerebral Metabolic Activator on Kaolin-Induced Hydrocephalus. In: Matsumoto, S., Tamaki, N. (eds) Hydrocephalus. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68156-4_7
Download citation
DOI: https://doi.org/10.1007/978-4-431-68156-4_7
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68158-8
Online ISBN: 978-4-431-68156-4
eBook Packages: Springer Book Archive