Skip to main content
SpringerLink
Log in

Biodegradable Polyphosphazenes for Biomedical Applications

  • Conference paper
Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems

Summary

A series of biodegradable polyphosphazenes with amino acid ester side groups were prepared starting from the poly (dichlorophosphazene). It was demonstrated that the rate of hydrolytic degradation can be varied by introduction of small amounts of depsipeptide side groups. Some selected polyphosphazenes were used to prepare implant devices containing mitomycin C (MMC). In vitro release studies demonstrated that the release rate can be controlled by the amino acid side group composition. Initial in vivo data indicates that i.p. implanted devices show promise for the treatment of tumour bearing animals.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. H.R. Allcock, Chem. Rev. 72, 315 (1972).

    Article  Google Scholar 

  2. H.R. Allcock, Contemporary Topics, Polymer Sci. 3, 55 (1979).

    Article  Google Scholar 

  3. H.R. Allcock, Makromol. Chem., Macromol. Symp. 6, 101 (1986).

    Article  Google Scholar 

  4. J.H. Goedemoed, J.H. Crommen and E.H. Schacht, in: Polyphosphazene drug delivery systems for antitumor treatment, ed. J.H. Goedemoed, V.U. University press, Amsterdam, Chapter I, (1990).

    Google Scholar 

  5. H.R. Allcock, T.J. Fuller, D.P. Mack, K. Matsumura and K.M. Smeltz, Macromolecules 10, 824 (1977).

    Article  Google Scholar 

  6. H.R. Allcock, T.J. Fuller and K. Matsumura, Inorg. Chem. 21, 515 (1982).

    Article  Google Scholar 

  7. H.R. Allcock, A.G. Scopelianis, Macromolecules 16, 715 (1983).

    Article  Google Scholar 

  8. H.J. Crommen, J. Vandorpe and E.H. Schacht, J. Controlled Release 24, 167–180 (1993).

    Article  Google Scholar 

  9. H.J. Crommen, E.H. Schacht and E.H. Mense, Biomaterials 11 (8), 511 (1992).

    Article  Google Scholar 

  10. H.J. Crommen, E.H. Schacht and E.H. Mense, Biomaterials 13. (8), 601 (1992).

    Article  Google Scholar 

  11. L.W. Seymour, R. Duncan, J. Duffy, S.Y. Ng and J. Heller, J. Controlled Release 11, 201–206 (1994).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biomaterial & Polymer Research Group, University of Ghent, Krijgslaan 281, B-9000, Ghent, Belgium

    E. Schacht, J. Vandorpe, J. Crommen & L. Seymour

  2. Cancer Research Campaign Laboratory, Clinical Oncology, Queen Elizabeth Hospital, University of Birmingham, B15 2TH, Birmingham, UK

    L. Seymour

Authors
  1. E. Schacht
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Vandorpe
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Crommen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. Seymour
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Chemistry, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo, 102, Japan

    Naoya Ogata Ph.D. (Professor) (Professor)

  2. Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, 84112, USA

    Sung Wan Kim Ph.D. (Professor and Director) (Professor and Director)

  3. Department of Chemical Technology and Institute of Biomedical Technology, University of Twente, P.O. Box 217, 7500 AD, Enschede, The Netherlands

    Jan Feijen Ph.D. (Professor) (Professor)

  4. Institute of Biomedical Engineering, Tokyo Women’s Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162, Japan

    Teruo Okano Ph.D. (Professor) (Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Tokyo

About this paper

Cite this paper

Schacht, E., Vandorpe, J., Crommen, J., Seymour, L. (1996). Biodegradable Polyphosphazenes for Biomedical Applications. In: Ogata, N., Kim, S.W., Feijen, J., Okano, T. (eds) Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65883-2_16

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-65883-2_16

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-65885-6

  • Online ISBN: 978-4-431-65883-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation