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Toward Clinical Application of Resting-State Functional Magnetic Resonance Imaging to Dementia

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Neuroimaging Diagnosis for Alzheimer's Disease and Other Dementias

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Abstract

Functional magnetic resonance imaging (fMRI) has been widely used to assess brain activity in many fields including cognitive neuroscience and clinical medicine. Typically, fMRI requires a participant to perform a task of the investigator’s interest during MRI acquisition. In this chapter, we introduce an emerging variant of the fMRI technique, resting-state fMRI (rs-fMRI), or resting-state functional connectivity MRI (rsfcMRI), in which a participant is only required to lie quietly within an MRI scanner. That is, rs-fMRI/rsfcMRI does not impose a demanding task on a participant. This property is potentially advantageous for the application of rs-fMRI/rsfcMRI to patients with neuropsychiatric disorders, including dementia, who might have difficulty performing tasks. We discuss the potential of rs-fMRI/rsfcMRI for the diagnosis of dementia and for understanding the mechanism underlying its clinical symptoms, taking into consideration that rs-fMRI/rsfcMRI functional connectivity analysis is increasingly used to identify subtle brain network changes caused by the pathophysiology of dementia.

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Authors and Affiliations

  1. Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan

    Yousuke Ogata & Takashi Hanakawa

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  1. Yousuke Ogata
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  2. Takashi Hanakawa
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Correspondence to Takashi Hanakawa .

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Editors and Affiliations

  1. Integrative Brain Imaging Center, National Center of Neurology & Psychiatry, Kodaira, Tokyo, Japan

    Hiroshi Matsuda

  2. Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

    Takashi Asada

  3. Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan

    Aya Midori Tokumaru

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Ogata, Y., Hanakawa, T. (2017). Toward Clinical Application of Resting-State Functional Magnetic Resonance Imaging to Dementia. In: Matsuda, H., Asada, T., Tokumaru, A. (eds) Neuroimaging Diagnosis for Alzheimer's Disease and Other Dementias. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55133-1_8

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  • DOI: https://doi.org/10.1007/978-4-431-55133-1_8

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