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Diffusion Tensor Imaging in Dementia

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Neuroimaging Diagnosis for Alzheimer's Disease and Other Dementias

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Abstract

While there are huge number of reports in the gray matter changes in Alzheimer’s disease (AD), there are also increasing number of reports on white matter changes in the cases of AD due to the development of diffusion tensor methods. This report summarizes the recent knowledge about white matter lesions in Alzheimer’s disease.

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References

  1. Warren JD, Schott JM, Fox NC, et al. Brain biopsy in dementia. Brain. 2005;128(Pt 9):2016–25.

    Article  CAS  PubMed  Google Scholar 

  2. Terada S, Ishizu H, Yokota O, et al. An autopsy case of hereditary diffuse leukoencephalopathy with spheroids, clinically suspected of Alzheimer’s disease. Acta Neuropathol. 2004;108(6):538–45.

    Article  PubMed  Google Scholar 

  3. Salat DH, Greve DN, Pacheco JL, et al. Regional white matter volume differences in nondemented aging and Alzheimer’s disease. NeuroImage. 2009;44(4):1247–58.

    Article  PubMed  Google Scholar 

  4. Rose SE, Chen F, Chalk JB, et al. Loss of connectivity in Alzheimer’s disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging. J Neurol Neurosurg Psychiatry. 2000;69(4):528–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Head D, Buckner RL, Shimony JS, et al. Differential vulnerability of anterior white matter in nondemented aging with minimal acceleration in dementia of the Alzheimer type: evidence from diffusion tensor imaging. Cereb Cortex. 2004;14(4):410–23.

    Article  PubMed  Google Scholar 

  6. Taoka T, Iwasaki S, Sakamoto M, et al. Diffusion anisotropy and diffusivity of white matter tracts within the temporal stem in Alzheimer disease: evaluation of the “tract of interest” by diffusion tensor tractography. AJNR Am J Neuroradiol. 2006;27(5):1040–5.

    CAS  PubMed  Google Scholar 

  7. Taoka T, Morikawa M, Akashi T, et al. Fractional anisotropy – threshold dependence in tract-based diffusion tensor analysis: evaluation of the uncinate fasciculus in Alzheimer disease. AJNR Am J Neuroradiol. 2009;30(9):1700–3.

    Google Scholar 

  8. Yendiki A, Panneck P, Srinivasan P, et al. Automated probabilistic reconstruction of white-matter pathways in health and disease using an atlas of the underlying anatomy. Front Neuroinform. 2011;5:23.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Smith SM, Jenkinson M, Johansen-Berg H, et al. Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. NeuroImage. 2006;31(4):1487–505.

    Article  PubMed  Google Scholar 

  10. Kin T, Hirano M, Taoka T, et al. Global and region-specific analyses of apparent diffusion coefficient in dentatorubral-pallidoluysian atrophy. AJNR Am J Neuroradiol. 2006;27(7):1463–6.

    Google Scholar 

  11. Sporns O, Tononi G, Kotter R. The human connectome: a structural description of the human brain. PLoS Comput Biol. 2005;1(4):e42.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Hori M, Fukunaga I, Masutani Y, et al. Visualizing non-Gaussian diffusion: clinical application of q-space imaging and diffusional kurtosis imaging of the brain and spine. Magn Reson Med Sci. 2012;11(4):221–33.

    Article  PubMed  Google Scholar 

  13. Tighe SK, Oishi K, Mori S, et al. Diffusion tensor imaging of neuropsychiatric symptoms in mild cognitive impairment and Alzheimer’s dementia. J Neuropsychiatry Clin Neurosci. 2012;24(4):484–8.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Fischer FU, Scheurich A, Wegrzyn M, et al. Automated tractography of the cingulate bundle in Alzheimer’s disease: a multicenter DTI study. J Magn Reson Imaging. 2012;36(1):84–91.

    Article  PubMed  Google Scholar 

  15. Damoiseaux JS, Smith SM, Witter MP, et al. White matter tract integrity in aging and Alzheimer’s disease. Hum Brain Mapp. 2009;30(4):1051–9.

    Article  PubMed  Google Scholar 

  16. Stricker NH, Schweinsburg BC, Delano-Wood L, et al. Decreased white matter integrity in late-myelinating fiber pathways in Alzheimer’s disease supports retrogenesis. NeuroImage. 2009;45(1):10–6.

    Article  CAS  PubMed  Google Scholar 

  17. Preti MG, Baglio F, Lagana MM, et al. Assessing corpus callosum changes in Alzheimer’s disease: comparison between tract-based spatial statistics and atlas-based tractography. PLoS One. 2012;7(4):e35856.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Reijmer YD, Leemans A, Caeyenberghs K, et al. Disruption of cerebral networks and cognitive impairment in Alzheimer disease. Neurology. 2013;80(15):1370–7.

    Article  PubMed  Google Scholar 

  19. Daianu M, Jahanshad N, Nir TM, et al. Breakdown of brain connectivity between normal aging and Alzheimer’s disease: a structural k-core network analysis. Brain Connect. 2013;3(4):407–22.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Falangola MF, Jensen JH, Tabesh A, et al. Non-Gaussian diffusion MRI assessment of brain microstructure in mild cognitive impairment and Alzheimer’s disease. Magn Reson Imaging. 2013;31(6):840–6.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Gold BT, Powell DK, Andersen AH, Smith CD. Alterations in multiple measures of white matter integrity in normal women at high risk for Alzheimer’s disease. NeuroImage. 2010;52(4):1487–94.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Salat DH, Tuch DS, van der Kouwe AJ, et al. White matter pathology isolates the hippocampal formation in Alzheimer’s disease. Neurobiol Aging. 2010;31(2):244–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Rogalski E, Stebbins GT, Barnes CA, et al. Age-related changes in parahippocampal white matter integrity: a diffusion tensor imaging study. Neuropsychologia. 2012;50(8):1759–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Brun A, Englund E. A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study. Ann Neurol. 1986;19(3):253–62.

    Article  CAS  PubMed  Google Scholar 

  25. Agosta F, Pievani M, Sala S, et al. White matter damage in Alzheimer disease and its relationship to gray matter atrophy. Radiology. 2011;258(3):853–63.

    Article  PubMed  Google Scholar 

  26. de la Monte SM. Quantitation of cerebral atrophy in preclinical and end-stage Alzheimer’s disease. Ann Neurol. 1989;25(5):450–9.

    Article  PubMed  Google Scholar 

  27. Chalmers K, Wilcock G, Love S. Contributors to white matter damage in the frontal lobe in Alzheimer’s disease. Neuropathol Appl Neurobiol. 2005;31(6):623–31.

    Article  CAS  PubMed  Google Scholar 

  28. Xu J, Chen S, Ahmed SH, et al. Amyloid-beta peptides are cytotoxic to oligodendrocytes. J Neurosci. 2001;21(1):RC118.

    CAS  PubMed  Google Scholar 

  29. Alonso AC, Zaidi T, Grundke-Iqbal I, Iqbal K. Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proc Natl Acad Sci U S A. 1994;91(12):5562–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Chabriat H, Pappata S, Poupon C, et al. Clinical severity in CADASIL related to ultrastructural damage in white matter: in vivo study with diffusion tensor MRI. Stroke. 1999;30(12):2637–43.

    Google Scholar 

  31. Acosta-Cabronero J, Patterson K, Fryer TD, et al. Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story. Brain. 2011;134(Pt 7):2025–35.

    Article  PubMed  Google Scholar 

  32. Galantucci S, Tartaglia MC, Wilson SM, et al. White matter damage in primary progressive aphasias: a diffusion tensor tractography study. Brain. 2011;134(Pt 10):3011–29.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Ragin AB, Storey P, Cohen BA, Epstein LG, Edelman RR. Whole brain diffusion tensor imaging in HIV-associated cognitive impairment. AJNR Am J Neuroradiol. 2004;25(2):195–200.

    PubMed  PubMed Central  Google Scholar 

  34. Taoka T, Sakamoto M, Akashi T. q-space imaging in the clinical cases with Alzheimer disease: analysis of fibers in the limbic system. In: Proceedings of the 20th annual meeting of ISMRM; 2012. p. 983.

    Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan

    Toshiaki Taoka

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  1. Toshiaki Taoka
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Correspondence to Toshiaki Taoka .

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Editors and Affiliations

  1. Integrative Brain Imaging Center, National Center of Neurology & Psychiatry, Kodaira, Tokyo, Japan

    Hiroshi Matsuda

  2. Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

    Takashi Asada

  3. Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan

    Aya Midori Tokumaru

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Taoka, T. (2017). Diffusion Tensor Imaging in Dementia. In: Matsuda, H., Asada, T., Tokumaru, A. (eds) Neuroimaging Diagnosis for Alzheimer's Disease and Other Dementias. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55133-1_5

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  • DOI: https://doi.org/10.1007/978-4-431-55133-1_5

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-55132-4

  • Online ISBN: 978-4-431-55133-1

  • eBook Packages: MedicineMedicine (R0)

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