Abstract
Recent advances in biomarkers and genetic studies have indicated that the pathophysiological process of Alzheimer’s disease (AD) takes place many years before the onset of dementia. Based on these findings, the diagnostic criteria for AD established in 1984 have recently been updated by the National Institute on Aging/Alzheimer’s Association (NIA-AA) incorporating biomarkers into it. The expert workgroup proposed three phases of AD progression over time—AD dementia, mild cognitive impairment due to AD, and preclinical AD. The American Psychiatric Association has published the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders, in which dementia has been renamed a major neurocognitive disorder, and a concept of mild neurocognitive disorder has been introduced. These new guidelines are expected to improve clinical diagnosis and to help establish new therapeutic intervention for AD in the future.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology. 1984;34(7):939–44.
America Psychiatric Association. Diagnostic and statistical manual of mental disorders (IV-TR), 4th ed.─text revised. Washington, DC: American Psychiatric Publishing; 2000.
Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):270–9. doi:10.1016/j.jalz.2011.03.008.
McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):263–9. doi:10.1016/j.jalz.2011.03.005.
Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR Jr, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH. Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):280–92. doi:10.1016/j.jalz.2011.03.003.
Jack CR Jr, Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, Thies B, Phelps CH. Introduction to the recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):257–62. doi:10.1016/j.jalz.2011.03.004.
America Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Washington, DC: American Psychiatric Publishing; 2013.
Mendiratta P, Wei JY. Diagnosing Alzheimer’s disease: update for the primary care clinician. J Ark Med Soc. 2014;110(8):160–3.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer Japan
About this chapter
Cite this chapter
Arai, T. (2017). Diagnostic Criteria for Alzheimer’s Disease. In: Matsuda, H., Asada, T., Tokumaru, A. (eds) Neuroimaging Diagnosis for Alzheimer's Disease and Other Dementias. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55133-1_2
Download citation
DOI: https://doi.org/10.1007/978-4-431-55133-1_2
Published:
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-55132-4
Online ISBN: 978-4-431-55133-1
eBook Packages: MedicineMedicine (R0)