Abstract
Over the last decade, research using positron emission tomography (PET) or single photon-emission computed tomography (SPECT) has revealed the distinguishing regional cerebral hypometabolism or hypoperfusion in various neurodegenerative disorders, which is useful for differential diagnosis of diseases. In addition to that, development of statistical analysis of neuroimaging data unveiled the subtle changes which was difficult to notice with visual inspection. SPECT findings of typical AD are characterized with hypoperfusion in (1) parietotemporal association cortex, (2) posterior cingulate gyrus and precuneus, and (3) medial temporal areas. Hypoperfusion in these regions might be a predictor for cognitive decline. With these findings, the neuroimaging examinations have become essential in clinical settings for the purpose of diagnosis of very early Alzheimer’s disease (AD) at a prodromal stage, prediction of conversion from mild cognitive impairment (MCI) to AD, or differential diagnosis from other diseases causing dementia.
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Nemoto, K. (2017). Brain Perfusion SPECT in Alzheimer’s Disease. In: Matsuda, H., Asada, T., Tokumaru, A. (eds) Neuroimaging Diagnosis for Alzheimer's Disease and Other Dementias. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55133-1_11
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