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Structures of Nascent Polypeptide Chain-Dependent-Stalled Ribosome Complexes

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Regulatory Nascent Polypeptides

Abstract

As the nascent polypeptide chain is being synthesized, it passes through a tunnel within the large ribosomal subunit. Rather than a passive conduit for the nascent chain, accumulating evidence indicates that specific nascent polypeptide chains can establish distinct interactions with the ribosomal tunnel to induce translation arrest. Cryo-EM structures of nascent peptide-dependent stalled ribosome complexes (SRC) have provided the first structural insights into how the nascent polypeptide chain interacts with the ribosomal tunnel to inhibit ribosome function.

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Authors and Affiliations

  1. Gene Center and Department of Biochemistry, Munich (CiPSM), Feodor-Lynenstr. 25, 81377, Munich, Germany

    Daniel N. Wilson & Roland Beckmann

  2. Center for Integrated Protein Science, Munich (CiPSM), Feodor-Lynen Str. 25, 81377, Munich, Germany

    Daniel N. Wilson & Roland Beckmann

Authors
  1. Daniel N. Wilson
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  2. Roland Beckmann
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Correspondence to Daniel N. Wilson or Roland Beckmann .

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Editors and Affiliations

  1. Kyoto Sangyo University, Kita-ku, Kyoto, Japan

    Koreaki Ito

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Wilson, D.N., Beckmann, R. (2014). Structures of Nascent Polypeptide Chain-Dependent-Stalled Ribosome Complexes. In: Ito, K. (eds) Regulatory Nascent Polypeptides. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55052-5_3

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