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LD for Lung Transplantation

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Marginal Donors

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Abstract

Living-donor lobar lung transplantation (LDLLT) has been performed as a lifesaving procedure for critically ill patients who are unlikely to survive the long wait for cadaveric lungs. In this relatively new procedure, the right and left lower lobes from two healthy donors are implanted in the recipient in place of the whole right and left lungs, respectively. Although immediate family members have been the only donors in Japan, non-Japanese institutions have accepted extended family members and unrelated individuals. Potential donors should be competent, willing to donate free of coercion, medically and psychosocially suitable, fully informed of the risks and benefits as a donor, and fully informed of risks, benefits, and alternative treatment available to the recipient. Morbidity rates after donor lobectomy varied from 20 % to 60 % but there has been no reported perioperative mortality of a lung donor. Donor forced vital capacity decreased by 11–16 %, indicating that it was preserved better than expected. The survival of recipients receiving LDLLT was similar or better than cadaveric lung transplantation. On the other hand, long-term outcomes of live donors have not been well documented. More studies will be needed to understand the experience of live lung donors.

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Authors and Affiliations

  1. The Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan

    Hiroshi Date

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  1. Hiroshi Date
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Correspondence to Hiroshi Date .

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Editors and Affiliations

  1. Department of Surgery and Clinical Research Center, Chiba-East National Hospital,, Chiba, Japan

    Takehide Asano

  2. Department of Therapeutics for End-Stage Organ Dysfunction, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

    Norihide Fukushima

  3. Department of Organ Transplant Surgery, Fujita Health University, Aichi, Japan

    Takashi Kenmochi

  4. Division for Innovative Surgery and Transplantation, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan

    Naoto Matsuno

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© 2014 Springer Japan

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Date, H. (2014). LD for Lung Transplantation. In: Asano, T., Fukushima, N., Kenmochi, T., Matsuno, N. (eds) Marginal Donors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54484-5_8

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  • DOI: https://doi.org/10.1007/978-4-431-54484-5_8

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54483-8

  • Online ISBN: 978-4-431-54484-5

  • eBook Packages: MedicineMedicine (R0)

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