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Roles of Prostaglandin E2 in Endometriosis

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Endometriosis

Abstract

Endometriosis is one of the most common gynecological diseases, affecting approximately 10 % of women in reproductive age. It is characterized as the presence of endometrial-like glands and stroma outside the uterus, commonly on the pelvic peritoneum and ovaries. The major symptoms of endometriosis include pelvic pain, dysmenorrhea, dyspareunia, and infertility. During the past decade, intensive investigations on molecular mechanisms responsible for the pathological processes of endometriosis have been conducted. Although many factors have been reported to be involved in these processes, prostaglandin E2 (PGE2) no doubt represents as one of the most critical regulators of all. Accumulating data demonstrate that PGE2 controls many critical functions, such as steroidogenesis, angiogenesis, proliferation, and immune suppression that contribute to the pathogenesis of endometriosis. Herein, we will summarize the most up-to-date information regarding the functional roles of PGE2 in the development and maintenance of endometriosis.

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Acknowledgment

This work was supported by grants from National Science Council of Taiwan (NSC-101-2320-B-006-030-MY3 to SJT and NSC-101-2314-B-006-043-MY2 to MHW). KYH wrote the first draft and proof-read the final manuscript. MHW and SJT edited and wrote the final draft. SJT designed and supervised the project. All authors read and approved the final draft.

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Authors and Affiliations

  1. Department of Physiology, College of Medicine, National Cheng Kung University, 1 University Road, Tainan, 70101, Taiwan

    Kuei-Yang Hsiao & Shaw-Jenq Tsai Ph.D.

  2. Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University, 1 University Road, Tainan, 70101, Taiwan

    Meng-Hsing Wu

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  1. Kuei-Yang Hsiao
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  2. Meng-Hsing Wu
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  3. Shaw-Jenq Tsai Ph.D.
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Correspondence to Shaw-Jenq Tsai Ph.D. .

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  1. Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Tottori, Japan

    Tasuku Harada

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Hsiao, KY., Wu, MH., Tsai, SJ. (2014). Roles of Prostaglandin E2 in Endometriosis. In: Harada, T. (eds) Endometriosis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54421-0_9

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  • DOI: https://doi.org/10.1007/978-4-431-54421-0_9

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