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Tailored Synthetic Surfaces to Control Human Pluripotent Stem Cell Self-Renewal

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Chembiomolecular Science

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Abstract

The ability to grow human cells ex vivo is the basis for remarkable advances in fields ranging from cell biology to medicine. From Gey’s demonstration that human cancer cells can be cultured in vitro [1] to Thomson’s derivation of human embryonic stem (hES) cells [2] to Yamanaka’s reprogramming of fibroblasts to induced pluripotent stem (iPS) cells [3], new opportunities have emerged with access to renewable supplies of human cells. Human pluripotent stem cells (hPS cells, which consist of hES and iPS cells) have the notable capacity to both self-renew indefinitely and differentiate into many different cell types [2–4]. These attributes of hPS cells have engendered excitement because of the cell’s potential applications. For example, they could advance regenerative medicine by serving as renewable sources of specialized human cell types for repair of damaged tissue or organs. In addition, they could be used in drug discovery to identify drug leads and to evaluate lead metabolism and toxicity [5, 6]. Moreover, patient-derived iPS cell lines provide the means to understand disease progression and devise new therapies [7]. Finally, the study of hPS cells can reveal the molecular mechanisms underlying human development.

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Author information

Authors and Affiliations

  1. Departments of Chemistry and Biochemistry, University of Wisconsin-Madison, Madison, WI, USA

    Laura L. Kiessling

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  1. Laura L. Kiessling
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Correspondence to Laura L. Kiessling .

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Editors and Affiliations

  1. Institute of Microbial Chemistry, Kamioosaki 3-14-23, Tokyo, 141-0021, Japan

    Masakatsu Shibasaki

  2. The University of Tokyo, Department of Pharmacology, Graduate School of Medicine, Hongo 7-3-1, Bunkyo-ku, 113-0033, Japan

    Masamitsu Iino

  3. RIKEN Advanced Science Institute, Antibiotics Laboratory, Chemical Biology Core Facility, 2-1, Hirosawa, Wako, 351-0198, Saitama, Japan

    Hiroyuki Osada

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Kiessling, L.L. (2012). Tailored Synthetic Surfaces to Control Human Pluripotent Stem Cell Self-Renewal. In: Shibasaki, M., Iino, M., Osada, H. (eds) Chembiomolecular Science. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54038-0_15

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