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Fate Specification of Neural Stem Cells

  • Chapter
Neurogenesis in the Adult Brain I

Abstract

Neural stem cells (NSCs) possess the ability to self-renew and to ­differentiate along neuronal and glial lineages. At the molecular level, these ­processes are currently defined in terms of a dynamic interplay between extracellular cues, including cytokine signaling, and intracellular programs such as epigenetic modification, including histone methylation and acetylation and DNA methylation. This review discusses recent advances in our understanding of the molecular mechanisms that control the specification of neuronal, astroglial, and oligodendroglial fates in NSCs of the developing and adult central nervous system.

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Acknowledgements

We thank Dr. Ian Smith for helpful comments and critical reading of the manuscript. We are very grateful to M. Ueda for her excellent secretarial assistance.

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Authors and Affiliations

  1. Laboratory of Molecular Neuroscience, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, 630-0101, Japan

    Masakazu Namihira & Kinichi Nakashima

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  1. Masakazu Namihira
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  2. Kinichi Nakashima
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Correspondence to Kinichi Nakashima .

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Editors and Affiliations

  1. Department of Histology and Neuroanatomy, Tokyo Medical University, Tokyo, 160-8402, Japan

    Tatsunori Seki Ph.D. (Professor) (Professor)

  2. Department of Developmental and Regenerative Biology, Institute of Molecular Medicine Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan

    Kazunobu Sawamoto Ph.D. (Professor) (Professor)

  3. Department of Neurology, University of Michigan, 109 Zina Pitcher Place 5021 BSRB, Ann Arbor, MI, 48109, USA

    Jack M. Parent M.D. (Associate Professor) & Arturo Alvarez-Buylla Ph.D. (Professor) (Associate Professor) &  (Professor)

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Namihira, M., Nakashima, K. (2011). Fate Specification of Neural Stem Cells. In: Seki, T., Sawamoto, K., Parent, J.M., Alvarez-Buylla, A. (eds) Neurogenesis in the Adult Brain I. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53933-9_3

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