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Pathophysiology of Gastroesophageal Reflux Disease and Indication for Surgical Therapy

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Surgery of the Esophagus

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Abstract

Gastroesophageal reflux disease is one of the most common diseases in western societies. The prevalence is estimated to be around 10% in those populations, if the presence of the disease is based on weekly or daily reflux symptoms [1–3]. The disease has been diagnosed more often due to increased and improved diagnostic activities, but there is also a true increase in incidence of the problem. Since it is related to western lifestyle, eating habits and environmental factors are discussed. In addition in recent years, detection of extraesophageal problems, especially respiratory symptoms and problems, is increasing, often related to reflux [4, 5]. A special interest in this disorder has emerged in the past 15 years since studies have shown the possible connection between reflux, the development of intestinal metaplasia in the esophagus, and the increase in the incidence of adenocarcinoma in Barrett’s esophagus [6–10].

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Authors and Affiliations

  1. Department of Surgery, Markus-Krankenhaus, Frankfurter Diakonie-Kliniken Wilhelm-Epstein-Straße 2, 60431, Frankfurt am Main, Germany

    Karl-Hermann Fuchs MD

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J. R. Izbicki D. C. Broering E. F. Yekebas A. Kutup A. F. Chernousov Y. I. Gallinger P. M. Bogopolski N. Soehendra

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Fuchs, KH. (2009). Pathophysiology of Gastroesophageal Reflux Disease and Indication for Surgical Therapy. In: Izbicki, J.R., et al. Surgery of the Esophagus. Steinkopff. https://doi.org/10.1007/978-3-7985-1743-1_7

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  • DOI: https://doi.org/10.1007/978-3-7985-1743-1_7

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