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Dual role of IL-17 in allergic asthma

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Th 17 Cells: Role in Inflammation and Autoimmune Disease

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

A proinflammatory role of IL-17 in autoimmune disorders has been favored, although there is evidence that IL-17 has a dual role as negative regulator. Here we review the concept of dual IL-17 functions in the light of recent strategies to use IL-17 neutralization as potential alternative to neutralizing TNF and IL-1 treatments in chronic inflammatory disorders. Expectedly, in allergic lung inflammation, neutralization of IL-17 inhibited neutrophil recruitment. However, this IL-17 antibody treatment concomitantly increased eosinophil recruitment by neutralizing IL-17’s dual role as negative regulator. IL-17 negatively regulated dendritic cell function and activation of T helper cell (Th)2 cytokine production. Furthermore, IL-17 inhibited Th2-characteristic chemokine and adhesion molecule expression. On a mechanistic level, IL-17 acted on IκB-β by preventing degradation and in turn leading to reduced NF-κB activation or IL-17 inhibited transcription factor IRF-1. Therefore, anti-IL-17 therapy, although presenting a promising lead in chronic inflammatory disorders, bears a potential risk of exacerbating allergic asthma.

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Author information

Authors and Affiliations

  1. Molecular Immunology and Embryology (IEM), Université d’Orléans and CNRS, 3B rue de la Férollerie, 45071, Orléans Cedex 2, France

    Bruno Schnyder & Silvia Schnyder-Candrian

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  1. Bruno Schnyder
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  2. Silvia Schnyder-Candrian
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Editors and Affiliations

  1. Molecular Immunology and Embryology, University of Orléans and CNRS UMR6218, 45071, Orléans, France

    Valérie Quesniaux  & Bernhard Ryffel  & 

  2. Novartis Institutes for Biomedical Research, NIBR WSJ 386-906, 4002, Basel, Switzerland

    Franco Di Padova

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© 2009 Birkhäuser Verlag Basel/Switzerland

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Schnyder, B., Schnyder-Candrian, S. (2009). Dual role of IL-17 in allergic asthma. In: Quesniaux, V., Ryffel, B., Di Padova, F. (eds) Th 17 Cells: Role in Inflammation and Autoimmune Disease. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8681-8_8

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  • DOI: https://doi.org/10.1007/978-3-7643-8681-8_8

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-8680-1

  • Online ISBN: 978-3-7643-8681-8

  • eBook Packages: MedicineMedicine (R0)

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