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Course and outcome of bipolar disorder — focusing on depressive aspects

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Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy

Part of the book series: Milestones in Drug Therapy ((MDT))

Abstract

The prognosis of an illness is perhaps relatively more valuable in psychiatry than in other therapeutic areas, because the lack of a laboratory-based diagnostic test and poor biological markers in mental disorders limit outcome predictions based mostly on the information from the psychiatric interview and examination. This is particularly true in bipolar disorder. In this chapter the authors summarize the main factors predicting course and outcome in bipolar disorder with a focus on depressive symptoms. The natural course, the impact of first episode, the impact of depressive phase, cycle length, onset, age, gender, type of illness, personality traits and temperament, co-morbidity, family history, life events, and outcome features will be reviewed. Conceptual models and their prognostic value will be discussed as well.

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Authors and Affiliations

  1. Area Medical Center Vienna, Eli Lilly & Company, Madacs Imre u. 13-14, 1075, Budapest, Hungary

    Tamas Treuer

  2. Lilly Research Laboratories, Indianapolis, and McLean Hospital, Harvard Medical School, Belmont, MA, 02184, USA

    Mauricio Tohen

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  1. Tamas Treuer
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  2. Mauricio Tohen
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Editors and Affiliations

  1. Mood Disorders Research Unit Laboratory of Molecular Pathophysiology, National Institute of Mental Health Mark O. Hatfield Clinical Research Center, Unit 7SE Rm. 7-3445 10 Center Drive, Bethesda, Maryland, 20892, USA

    Carlos A. Zarate

  2. Laboratory of Molecular Pathophysiology, National Institute of Mental Health Porter Neuroscience Research Center, Building 35, Room 1C-917 36 Convent Drive, MSC 3711, Bethesda, Maryland, 20892, USA

    Husseini K. Manji

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Treuer, T., Tohen, M. (2009). Course and outcome of bipolar disorder — focusing on depressive aspects. In: Zarate, C.A., Manji, H.K. (eds) Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy. Milestones in Drug Therapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8567-5_3

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