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Complementary microarray technologies

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Microarrays in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

As outlined in the previous chapters of this book, the main microarray applications in inflammation rely on mRNA expression profiling based on either Oligo or cDNA microarray platforms. By virtue of measuring mRNA transcript levels, the activity of genes in inflammatory lesions can be analyzed. However, we have not focused solely on mRNA expression via microarray analysis over the last decade. Different disciplines from the genomics, glycomics, proteomics and metabolomics area have been combined in order to get an “all-inclusive” picture of the disease to be analysed. This combined approach has led to the creation of a new discipline named “systems biology”. Novel microarray-based technologies have been developed that enable the analysis of “messenger” molecules other than mRNA. The focus of the current chapter is on those microarray platforms which either already play or are expected to play an important role in our understanding of the pathogenesis of inflammation. In addition, all described microarray platforms are meant to speed up drug discovery in future research and/or serve as prognostic or diagnostic tools in inflammatory diseases. This overview will concentrate on microarray platforms developed for promoter or CpG methylation as well as Chromatin Immunoprecipitation on chip analysis (ChIP on Chip), array comparative genomic hybridization (aCGH), carbohydrate microarrays, protein microarrays and microarrays for the detection and analysis of microRNAs.

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Author information

Authors and Affiliations

  1. Miltenyi Biotec GmbH, Friedrich-Ebert-Strasse 68, 51429, Bergisch Gladbach, Germany

    Bernhard Gerstmayer

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  1. Bernhard Gerstmayer
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Editors and Affiliations

  1. Research & Development, Miltenyi Biotec GmbH, Friedrich-Ebert-Straße 68, 51429 Bergisch, Gladbach, Germany

    Andreas Bosio

  2. Miltenyi Biotec GmbH, Friedrich-Ebert-Straße 68, 51429 Bergisch, Gladbach, Germany

    Bernhard Gerstmayer

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© 2008 Birkhäuser Verlag Basel/Switzerland

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Gerstmayer, B. (2008). Complementary microarray technologies. In: Bosio, A., Gerstmayer, B. (eds) Microarrays in Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8334-3_17

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