Abstract
Bronchial asthma is a complicated and diverse disorder affected by genetic and environmental factors, with Th2-type inflammation dominant in its pathogenesis. However, the underlying molecular mechanism of bronchial asthma is still poorly understood. Microarray technology, now one of the most powerful tools for functional genomics, has been used in several trials to dissect the pathogenesis of bronchial asthma, providing some novel pathogenic mechanisms as well as information about gene-expression profiling. This article describes the recent outcomes of microarray analyses applied to bronchial tissues of asthma patients or asthma animal models and cultured cells related to the biological events in bronchial asthma. This information could be relevant for finding drug targets or biomarkers for bronchial asthma.
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Izuhara, K., Kanaji, S., Ohta, S., Shiraishi, H., Arima, K., Yuyama, N. (2008). Gene expression patterns in asthma. In: Bosio, A., Gerstmayer, B. (eds) Microarrays in Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8334-3_10
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DOI: https://doi.org/10.1007/978-3-7643-8334-3_10
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-7643-8333-6
Online ISBN: 978-3-7643-8334-3
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