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Chemokines and chemokine receptors

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New Therapeutic Targets in Rheumatoid Arthritis

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines. There is a redundancy and binding promiscuity between chemokine receptors and their ligands. Recently, a functional classification distinguishing between inflammatory and homeostatic chemokines has been introduced. However, numerous effects of these chemokines overlap. For example, numerous homeostatic chemokines, which are involved in lymphocyte recruitment and lymphoid tissue organization, may also play a role in B cell migration underlying germinal center formation within the inflamed synovium. Anti-chemokine and anti-chemokine receptor targeting may be therapeutically used in future biological therapy of arthritis. In addition to the clear clinical benefit, we can learn a lot from these trials about the actions of the targeted chemokines and their receptors. Today, most data in this field are obtained from experimental models of arthritis; however, results of some human trials have also become available. Thus, it is possible that a number of specific chemokine and chemokine receptor antagonists will be administered to arthritis patients in the near future. Hopefully, some of these potential treatment modalities will be used to control inflammation, prevent joint destruction and thus will benefit our patients.

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Authors and Affiliations

  1. Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Science Center, Debrecen, 4004, Hungary

    Zoltán Szekanecz

  2. Veterans’ Administration, Ann Arbor Healthcare System, Ann Arbor, MI, USA

    Alisa E. Koch

  3. Department of Internal Medicine, Division of Rheumatology, University of Michigan Health System, Ann Arbor, MI, USA

    Alisa E. Koch

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  1. Zoltán Szekanecz
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  2. Alisa E. Koch
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  1. Division of Clinical Immunology and Rheumatology EULAR & FOCIS Center of Excellence Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room F4-218, 1105, AZ Amsterdam, The Netherlands

    Paul-Peter Tak

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Szekanecz, Z., Koch, A.E. (2009). Chemokines and chemokine receptors. In: Tak, PP. (eds) New Therapeutic Targets in Rheumatoid Arthritis. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8238-4_8

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