Abstract
Oncostatin M (OSM) is a pleiotropic cytokine with potential utility as a treatment for inflammatory arthritis. This pro-inflammatory cytokine is increased in the rheumatoid but not in the osteoarthritic joint. Strategies to block the actions of OSM for use in inflammatory arthritis are being developed and these show significant promise in murine models of disease. Targeting OSM may have a beneficial effect by inhibiting some of the mechanisms of joint destruction in rheumatoid arthritis, which may limit long-term disability in patients. The challenge now is to convert this potential into firm compounds that can be tested in the clinic.
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Barnes, T.C., Moots, R.J. (2009). Targeting oncostatin M in the treatment of rheumatoid arthritis. In: Tak, PP. (eds) New Therapeutic Targets in Rheumatoid Arthritis. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8238-4_10
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DOI: https://doi.org/10.1007/978-3-7643-8238-4_10
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