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Chemical genetics: An evolving toolbox for target identification and lead optimization

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Systems Biological Approaches in Infectious Diseases

Part of the book series: Progress in Drug Research ((PDR,volume 64))

Abstract

Chemical genetics combines chemistry with biology as a means of exploring the function of unknown proteins or identifying the proteins responsible for a particular phenotype. Chemical genetics is thus a valuable tool in the identification of novel drug targets. This chapter describes the application of chemical genetics in traditional and systems-based approaches to drug target discovery and the tools/approaches that appear most promising for guiding future pharmaceutical development.

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Authors and Affiliations

  1. National Institutes of Health, Rockville, MD, 20852, USA

    Helena I. Boshoff & Cynthia S. Dowd

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  1. Helena I. Boshoff
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  2. Cynthia S. Dowd
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  1. Tuberculosis Research Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD, 20852, USA

    Helena I. Boshoff  & Clifton E. Barry III  & 

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Boshoff, H.I., Dowd, C.S. (2007). Chemical genetics: An evolving toolbox for target identification and lead optimization. In: Boshoff, H.I., Barry, C.E. (eds) Systems Biological Approaches in Infectious Diseases. Progress in Drug Research, vol 64. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7567-6_3

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