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Gene transfer technology

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In Vivo Models of Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Conclusion

In vivo gene transfer is a useful tool for generating animal models of disease, and for validating pathways that are involved in disease. The understanding that is gained through this technology can provide the information needed to develop new therapeutics specifically targeted at the pathways of interest. The choice of gene transfer vector will depend on the tissue and cell types to be transduced, the levels of gene expression needed, and the duration of gene expression. Recent advances in generating recombinant viral vectors, and the identification of new serotypes with different tropism, allow for the generation of a wide range of animal models.

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Author information

Authors and Affiliations

  1. Biopharmaceuticals CEDD, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA, 19406, USA

    Karen F. Kozarsky

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  1. Karen F. Kozarsky
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Editor information

Editors and Affiliations

  1. Novartis Institutes for Biomedical Research Respiratory Disease Area, Novartis Horsham Research Centre, Wimblehurst Road, Horsham, West Sussex, UK

    Christopher S. Stevenson

  2. Johnson and Johnson PRD, Welsh & McKean Rd, Spring House, PA, 19477, USA

    Lisa A. Marshall

  3. Portfolio, Program and Alliance Management BiogenIdec, 14 Cambridge Center, Cambridge, MA, 02142, USA

    Douglas W. Morgan

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© 2006 Birkhäuser Verlag Basel/Switzerland

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Kozarsky, K.F. (2006). Gene transfer technology. In: Stevenson, C.S., Marshall, L.A., Morgan, D.W. (eds) In Vivo Models of Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7520-1_6

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  • DOI: https://doi.org/10.1007/978-3-7643-7520-1_6

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-7519-5

  • Online ISBN: 978-3-7643-7520-1

  • eBook Packages: MedicineMedicine (R0)

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