Zusammenfassung
Das ARDS („adult respiratory distress syndrome“) wurde erstmals 1967 von Ashbaugh und Mitarbeitern [1]. beschrieben. Trotz der vielschichtigen Ursachen wie u. a. Sepsis, Schock, Pneumonie, Trauma und Aspiration ist das ARDS unabhängig von der Ätiologie gekennzeichnet durch a) eine ausgeprägte, Sauerstoff-refraktäre arterielle Hypoxämie, b) einen erhöhten intrapulmonalen Shunt, c) eine verminderte Lungencompliance und d) ein reduziertes Lungenvolumen bei fehlendem Hinweis auf linksventrikuläres Versagen.
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Literatur
Absaugh DG, Bigelow DB, Petty TL, Levine BE (1967) Acute respiratory distress in adults. Lancet ii: 319–323
Seeger W, Günther A, Walmrath HD, Grimminger F, Lasch HG (1993) Alveolar surfactant and adult respiratory distress syndrome. Clin Invest 71: 177–190
Spragg RG, Gilliard N, Richman P, Smith RM, Hite D, Pappert D, Heldt GP, Meritt TA (1992) The adult respiratory distress syndrome: clinical aspects relevant to surfactant supplementation. In: Robertson B, Van Golde LMG, Batenburg JJ (eds) Pulmonary surfactant: from molecular biology to clinical practice. Elsevier Science Publishers, pp 685–703
Hamm H, Fabel H, Bartsch W (1992) The surfactant system of the adult lung: physiology and clinical perspectives. Clin Invest 70: 637–657
Hawgood S, Shiffer K (1991) Structure and properties of the surfactant-associated proteins. Ann Rev Physiol 53: 375–394
Dobbs LG, Wright JR, Gonzales R, Venstrom K, Nellenbogen J (1987) Pulmonary surfactant and its components inhibit secretion of phosphatidylcholine from cultured rat alevolar type II cells. Proc Natl Acad Sci 84: 1010–1014
Tsuzuki A, Kuroki Y, Akino T (1993) Pulmonary surfactant protein A-meditated uptake of phosphatidylcholine by alveolar type II cells. Am Physiol 265 (Lung Cell Mol Physiol 9): L193 - L199
Wright JR, Wager RE, Hawgood S, Dobbs LG, Clements JA (1987) Surfactant apoprotein Mr = 26.000–36.000 enhances uptake of liposomes by type II cells. J Biol Chem 262: 2888–2894
Petty TL, Silvers WG, Paul GW, Stanford RE (1979) Abnormalities in lung elastic properties and surfactant function in adult respiratory distress syndrome. Chest 75: 571–574
Hallman M, Spragg RG, Harrell JH, Moser KM, Gluck L (1982) Evidence of lung surfactant abnormality in respiratory failure, study of bronchoalveolar lavage phospholipids, surface activity, phospholipase activity, and plasma myoinositol. J Clin Invest 70: 673–683
Pison U, Obertacke U, Brand M, Seeger W, Joka T, Bruch J, SchmidtNeuerburg KP (1990) Altered pulmonary surfactant in uncomplicated and septicemia-complicated courses of acute respiratory failure. J Trauma 30: 19–26
Pison RL, Obertacke U, Seeger W, Hawgood S (1992) Surfactant protein A ( SP-A) is decreased in acute parenchymal lung injury associated with polytrauma. Eur J Clin Invest 22: 712–718
Greogry TJ, Longmore WJ, Moxley MA, Whitsett JA, Reed CR, Fowler III AA, Hudson LD, Maunder RJ, Crim C, Hyers TM (1991) Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome. J Clin Invest 88: 1976–1981
Spragg RG, Richman P, Gilliard N, Merritt TA (1987) The future for surfactant therapy of the adult respiratory distress syndrome. In: Lachmann B (ed) Surfactant replacement therapy. Springer, New York, pp 203–211
Li JJ, Sanders RL, McAdam KP, Hales CA, Thompson BT, Gelfand JA, Burke JF (1989) Impact of C-reactive protein ( CRP) on surfactant function. J Trauma 29: 1690–1697
Holm BA, Matalon S, Finkelstein JN, Notter RH (1988) Type II pneumocyte changes during hyperoxic lung injury and recovery. J Appl Physiol 65: 2672–2678
Edelson JD, Vadas P, Villar J, Mullen JBM, Pruzanski W (1991) Acute lung injury induced by phospholipase A2. Am Rev Resp Dis 143: 1102–1109
Oldham KT, Guice KS, Stetson PS, Wolfe RR (1989) Bacteremia-induced suppression of alveolar surfactant production. J Surg Res 47: 397–402
Lachmann B (1987) Surfactant replacement in acute respiratory failure: animal studies and first clinical trials. In: Lachmann B (ed) Surfactant replacement therapy. Springer, New York, pp 212–223
Nosaka S, Sakai T, Yonekura M, Yoshikawa K (1990) Surfactant for adults with respiratory failure. Lancet 336: 947–948
Subbig K, Schmidt H, Böhrer H, Huster Th, Bach A, Motsch J (1992) Surfactantapplikation bei akutem Lungenversagen. Anaesthesist 41: 555–558
Lewis J, Tabor B, Ikegami M, Jobe A (1991) Physiological response to aerosolized surfactant in lung-lavaged sheep. Am Rev Resp Dis 143: A769
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Schobersberger, W., Friedrich, F., Putz, G. (1994). Zellstoffwechsel des Alveolarepithels Typ II: Bedeutung bei der Therapie des ARDS. In: Kleinberger, G., Lenz, K., Ritz, R., Schneeweiß, B., Schuster, HP., Waldhäusl, W. (eds) Metabolismus. Intensivmedizinisches Seminar, vol 7. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9342-6_12
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DOI: https://doi.org/10.1007/978-3-7091-9342-6_12
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