Summary
rCBF, capillary permeability and vascular volume have been measured during the time course of interstitial stereotactic radiosurgery in normal and tumour-bearing dog brain. For rCBF measurement the stable Xenon-CT-technique with a modified Kety-Schmidt equation has been used, and for measurement of blood-to-brain transport of meglumine iothalamate the two-compartment CT-method as developed by Groothuis, which also reflects vascular volume. Anaplastic gliomas had been induced by intracerebral injection of avian sarcoma virus. Radiation sources have been 192-iridium and 198-gold.
Both of the isotopes caused spherical blood-brain-barrier lesions with a more than 10-fold blood-to-brain transport increase. These effects occurred earlier and more pronounced with 192-iridium, but much longer lasting with 198-gold.
Interstitial radiosurgery of the tumours led to a further increase of capillary permeability.
Blood flow was significantly lowered not only within radionecrosis but also in the adjacent brain areas.
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© 1993 Springer-Verlag Wien
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Warnke, P.C., Hans, F.J., Ostertag, C.B. (1993). Impact of Stereotactic Interstitial Radiation on Brain Capillary Physiology. In: Meyerson, B.A., Broggi, G., Martin-Rodriguez, J., Ostertag, C., Sindou, M. (eds) Advances in Stereotactic and Functional Neurosurgery 10. Acta Neurochirurgica, vol 58. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9297-9_19
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DOI: https://doi.org/10.1007/978-3-7091-9297-9_19
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